Muntjewerff, Elke M Parv, Kristel Mahata, Sushil K van Riessen, N Koen Phillipson, Mia Christoffersson, Gustaf van den Bogaart, Geert
Published in
Journal of leukocyte biology
Increased levels of the anti-inflammatory peptide Catestatin (CST), a cleavage product of the pro-hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (Mϕs) in inflamed tissues. Here, it is reported that CST blocks leu...
Kang, Ning Shi, Yuanyuan Song, Jiaxi Gao, Fei Fan, Mingyue Jin, Wei Gao, Yaran Lv, Peiyuan
Published in
Frontiers in Aging Neuroscience
Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effect...
Nederlof, Rianne Reidel, Sophia Spychala, André Gödecke, Stefanie Heinen, André Lautwein, Tobias Petzsch, Patrick Köhrer, Karl Gödecke, Axel
Published in
Frontiers in Immunology
Acute myocardial infarction (MI) induces an extensive sterile inflammation, which is dominated in the early phase by invading neutrophils and monocytes/macrophages. The inflammatory response after MI critically affects infarct healing and cardiac remodeling. Therefore, modulation of cardiac inflammation may improve outcome post MI. Insulin-like gro...
Paclet, Marie-Hélène Laurans, Salomé Dupré-Crochet, Sophie
Published in
Frontiers in Cell and Developmental Biology
Reactive oxygen species (ROS), produced by the phagocyte NADPH oxidase, NOX2, are involved in many leukocyte functions. An excessive or inappropriate ROS production can lead to oxidative stress and tissue damage. On the other hand, an absence of ROS production due to a lack of a functional NADPH oxidase is associated with recurrent infections as we...
Janssen, Pierre Tosi, Irene Hego, Alexandre Maréchal, Pauline Marichal, Thomas Radermecker, Coraline
Published in
Frontiers in Immunology
Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance. In horses, equine asthma can be subdivided into severe or moderate asthma according to clinical symptoms and the extent of airway neutrophilic inflammation. While severe asth...
Xiong, Yin Halima, Mahmoud Che, Xiaoyan Zhang, Yiming Schaaf, Marcel J. M. Li, Minghui Gao, Min Guo, Liqun Huang, Yan Cui, Xiuming
...
Published in
Frontiers in Pharmacology
Panax notoginseng (PN) is a Chinese medicinal herb that is traditionally used to treat inflammation and immune-related diseases. Its major active constituents are saponins, the types and levels of which can be changed in the process of steaming. These differences in saponins are causally relevant to the differences in the therapeutic efficacies of ...
Rubey, Kathryn M. Mukhitov, Alexander R. Nong, Jia Wu, Jichuan Krymskaya, Vera P. Myerson, Jacob W. Worthen, G. Scott Brenner, Jacob S.
Published in
Frontiers in Pharmacology
Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We and others have been developing drug-loaded nanoparticles that home to the sites of infection and inflammation via engineered tropism for neutrophils, the first-responder leukocytes in bacterial i...
Takemura, Moe Yamaguchi, Masaya Kobayashi, Momoko Sumitomo, Tomoko Hirose, Yujiro Okuzaki, Daisuke Ono, Masayuki Motooka, Daisuke Goto, Kana Nakata, Masanobu
...
Published in
Frontiers in Cellular and Infection Microbiology
Streptococcus pneumoniae is a major cause of invasive diseases such as pneumonia, meningitis, and sepsis, with high associated mortality. Our previous molecular evolutionary analysis revealed that the S. pneumoniae gene bgaA, encoding the enzyme β-galactosidase (BgaA), had a high proportion of codons under negative selection among the examined pneu...
Kaltenmeier, Christof Yazdani, Hamza O. Handu, Sanah Popp, Brandon Geller, David Tohme, Samer
Published in
Frontiers in Immunology
The innate immune system plays an essential role in the response to sterile inflammation and its association with liver ischemia and reperfusion injury (IRI). Liver IRI often manifests during times of surgical stress such as cancer surgery or liver transplantation. Following the initiation of liver IRI, stressed hepatocytes release damage-associate...
Leal-Silva, Thaís Lopes, Camila de Almeida Vieira-Santos, Flaviane Oliveira, Fabrício Marcus Silva Kraemer, Lucas Padrão, Luiza de Lima Silva Amorim, Chiara Cássia Oliveira Souza, Jorge Lucas Nascimento Russo, Remo Castro Fujiwara, Ricardo Toshio
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Published in
Frontiers in Immunology
IL-17 is a cytokine produced by innate and acquired immunity cells that have an action against fungi and bacteria. However, its action in helminth infections is unclear, including in Toxocara canis infection. Toxocariasis is a neglected zoonosis representing a significant public health problem with an estimated seroprevalence of 19% worldwide. In t...