Bozhanova, Nina G Sangha, Amandeep K Sevy, Alexander M Gilchuk, Pavlo Huang, Kai Nargi, Rachel S Reidy, Joseph X Trivette, Andrew Carnahan, Robert H Bukreyev, Alexander
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Marburg virus (MARV) disease is lethal, with fatality rates up to 90%. Neutralizing antibodies (Abs) are promising drug candidates to prevent or treat the disease. Current efforts are focused in part on vaccine development to induce such MARV-neutralizing Abs. We analyzed the antibody repertoire from healthy unexposed and previously MARV-infected i...
Bovay, Amandine Speiser, Daniel E Fuertes Marraco, Silvia A
Published in
Human vaccines & immunotherapeutics
Lymphocyte recirculation within the human body is essential for efficient pathogen detection and immune responses. So far, immune cell migration has been investigated largely using ovine and murine models, with little evidence in humans. Here, we analyzed peripheral blood of healthy individuals following primary vaccination with the Yellow Fever va...
Tan, Yun Liu, Feng Xu, Xiaoguang Ling, Yun Huang, Weijin Zhu, Zhaoqin Guo, Mingquan Lin, Yixiao Fu, Ziyu Liang, Dongguo
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Published in
Frontiers of medicine
The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination. He...
Egorova, M. S. Kurashova, S. S. Dzagurova, T. K. Balovneva, M. V. Ishmukhametov, A. A. Tkachenko, E. A.
Published in
Applied Biochemistry and Microbiology
AbstractHemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by the orthohantaviruses Puumala, Dobrava-Belgrad (four genotypes), Hantaan (genotype Amur), and Seoul. In the Russian Federation, HFRS occupies the leading place among all natural focal human diseases. Formaldehyde, β-propiolactone, and ultraviolet radiation w...
Valdivia, Arantxa Torres, Ignacio Latorre, Víctor Francés-Gómez, Clara Ferrer, Josep Forqué, Lorena Costa, Rosa de la Asunción, Carlos Solano Huntley, Dixie Gozalbo-Rovira, Roberto
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Published in
Journal of medical virology
Assessment of commercial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoassays for their capacity to provide reliable information on sera neutralizing activity is an emerging need. We evaluated the performance of two commercially available lateral flow immunochromatographic assays (LFIC; Wondfo SARS-CoV-2 Antibody test and the I...
Datta, Rohini Roy Chowdhury, Rohan Manjunath, Kavyashree Hanna, Luke Elizabeth Varadarajan, Raghavan
Published in
Proceedings of the National Academy of Sciences of the United States of America
Identification of specific epitopes targeted by neutralizing antibodies is essential to advance epitope-based vaccine design strategies. We report a facile methodology for rapid epitope mapping of neutralizing antibodies (NAbs) against HIV-1 Envelope (Env) at single-residue resolution, using Cys labeling, viral neutralization assays, and deep seque...
Rydyznski Moderbacher, Carolyn Ramirez, Sydney I Dan, Jennifer M Grifoni, Alba Hastie, Kathryn M Weiskopf, Daniela Belanger, Simon Abbott, Robert K Kim, Christina Choi, Jinyong
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Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specifi...
Sharma, Omna Sultan, Ali A. Ding, Hong Triggle, Chris R.
Published in
Frontiers in Immunology
A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and causes the highly infectious disease referred to as COVID-19. COVID-19 has now spread worldwide to become a global pandemic affecting over 24 million people as of August 26th, 2020 an...
Boppana, Sushma Qin, Kai Files, Jacob K Russell, Ronnie M. Stoltz, Regina Bibollet-Ruche, Frederic Bansal, Anju Erdmann, Nathan Hahn, Beatrice H. Goepfert, Paul
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Published in
medRxiv
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 21 convalescent individuals. Within the first two months following symptom onset, a majority of individuals (81%) mount at least...
Duan, Liangwei Zheng, Qianqian Zhang, Hongxia Niu, Yuna Lou, Yunwei Wang, Hui
Published in
Frontiers in immunology
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public health and imposes a severe burden on the entire human society. Like other coronaviruses, the SARS-CoV-2 genome encodes spike (S) glycoproteins, which protrude from the surface of...
