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Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification.

Published in Stem cells (Dayton, Ohio)

Midbrain dopamine (DA) neurons are associated with locomotor and psychiatric disorders. DA phenotype is specified in ancestral neural precursor cells (NPCs) and maintained throughout neuronal differentiation. Here we show that endogenous expression of MeCP2 coincides with DA phenotype specification in mouse mesencephalon, and premature expression o...