Grötsch, Maria Katharina Ehlert, Ulrike
Published in
Frontiers in Behavioral Neuroscience
Background Allopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes. Studies suggest a U-shaped effect of ALLO on mood, with some women being more sensitive to hormonal changes ...
balan, irina boero, giorgia chéry, samantha lucenell mcfarland, minna h. lopez, alejandro g. morrow, a. leslie
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularly in conditions like postpartum depression (PPD), ...
bellingacci, laura canonichesi, jacopo sciaccaluga, miriam megaro, alfredo mazzocchetti, petra di mauro, michela costa, cinzia di filippo, massimiliano pettorossi, vito enrico tozzi, alessandro
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Amyloid beta 1-42 (Aβ42) aggregates acutely impair hippocampal long-term potentiation (LTP) of synaptic transmission, and 17β-estradiol is crucial for hippocampal LTP. We tested whether boosting the synthesis of neural-derived 17β-estradiol (nE2) saves hippocampal LTP by the neurotoxic action of Aβ42. Electrophysiological recordings were performed ...
Marecki, Rafał Kałuska, Joanna Kolanek, Agata Hakało, Dominika Waszkiewicz, Napoleon
Published in
Frontiers in Psychiatry
With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis, major depression, insomnia, bipolar disorder, and Parkinson’s tremor, due to their ability to m...
Reddy, Doodipala Samba
Published in
Trends in molecular medicine
Postpartum depression (PPD) is associated with a decline in progesterone-derived anxiolytic-antidepressant neurosteroids after delivery. Neurosteroid replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the first drug treatment for PPD. Here we describe the molecular insights of the neurosteroid ...
Lin, Yiqi Christina Cheung, Garett Zhang, Zeyu Papadopoulos, Vassilios
Published in
The Journal of biological chemistry
Neurosteroids, which are steroids synthesized by the nervous system, can exert neuromodulatory and neuroprotective effects via genomic and nongenomic pathways. The neurosteroid and major steroid precursor pregnenolone has therapeutical potential in various diseases, such as psychiatric and pain disorders, and may play important roles in myelination...
Heimovics, Sarah Rubin, Nathan Ford, Morgan
Published in
Frontiers in Endocrinology
Introduction It has been proposed that in species that defend territories across multiple life history stages, brain metabolism of adrenal dehydroepiandrosterone (DHEA) regulates aggressive behavior at times when gonadal androgen synthesis is low (i.e. the non-breeding season). To date, a role for DHEA in the regulation of other forms of social beh...
stegemann, lennart norman neufeld, paula maria hecking, ines vorgerd, matthias matschke, veronika stahlke, sarah theiss, carsten
The enteric nervous system (ENS) is an intrinsic network of neuronal ganglia in the intestinal tube with about 100 million neurons located in the myenteric plexus and submucosal plexus. These neurons being affected in neurodegenerative diseases, such as Parkinson’s disease, before pathological changes in the central nervous system (CNS) become dete...
wang, jing pratap, uday yujiao, lu sareddy, gangadhara tekmal, rajeshwar vadlamudi, ratna brann, darrell
17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models. The aim of this study was to develop a tamoxifen (TMX)-inducible astrocyte-specific aromatase knockout m...
Kim, Soon-Ae Jang, Eun-Hye Lee, Jangjae Cho, Sung-Hee
Published in
International journal of molecular sciences
Valproic acid (VPA) is a known drug for treating epilepsy and mood disorders; however, it is not recommended for pregnant women because of its possible teratogenicity. VPA affects neurotransmission and gene expression through epigenetic mechanisms by acting as a histone deacetylase inhibitor and has been used to establish animal models of autism sp...
