Sommer, Alice J. Lee, Mihye Bind, Marie-Abèle C.
Published in
Palgrave Communications
Weather characteristics have been suggested by many social scientists to influence criminality. A recent study suggested that climate change may cause a substantial increase in criminal activities during the twenty-first century. The additional number of crimes due to climate have been ethoroughly discussed the first draft of the paper. Allstimated...
Cannon, Tyler Gruenheid, Samantha
Published in
Trends in microbiology
Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number of microorganisms have been associated with increased risk of PD in humans, and recent research u...
Liu, Che Lee, Sang H Loewenstein, David A Galvin, James E Camargo, Christian J Alperin, Noam
Published in
Journal of sleep research
Poor sleep quality is a known risk factor for Alzheimer's disease. This longitudinal imaging study aimed to determine the acceleration in the rates of tissue loss in cognitively critical brain regions due to poor sleep in healthy elderly individuals. Cognitively-normal healthy individuals, aged ≥60 years, reported Pittsburgh Sleep Quality Index (PS...
Cade, Shaun Zhou, Xin-Fu Bobrovskaya, Larisa
Published in
Reviews in the neurosciences
Alzheimer's disease is a neurodegenerative condition that is potentially mediated by synaptic dysfunction before the onset of cognitive impairments. The disease mostly affects elderly people and there is currently no therapeutic which halts its progression. One therapeutic strategy for Alzheimer's disease is to regenerate lost synapses by targeting...
Gumus, Arzu Bozdag, Murat Akdemir, Atilla Angeli, Andrea Selleri, Silvia Carta, Fabrizio Supuran, Claudiu T
Published in
Molecules (Basel, Switzerland)
A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase isoforms I, II, IX and XII showed selective activities on the tumor-associated IX and XII isozymes. Molecular modeling studies on selected compounds 14a and 22a were performed. The binding mod...
Borocci, Stefano Grandinetti, Felice Sanna, Nico
Published in
Molecules (Basel, Switzerland)
The structure, stability, and bonding situation of some exemplary noble gas-silicon cations were investigated at the MP2/aVTZ level of theory. The explored species include the mono-coordinated NgSiX3+ (Ng = He-Rn; X = H, F, Cl) and NgSiF22+ (Ng = He-Rn), the di-coordinated Ar2SiX3+ (X = H, F, Cl), and the "inserted" FNgSiF2+ (Ng = Kr, Xe, Rn). The ...
Qin, Lili Du, Fei Yang, Ningning Zhang, Chen Wang, Zhiwen Zheng, Xingwen Tang, Jiawei Yang, Liangbo Dong, Chen
Published in
Molecules (Basel, Switzerland)
As the largest group of structurally diverse metabolites, terpenoids are versatile natural compounds that act as metabolism mediators, plant volatiles, and ecological communicators. However, few terpenoid compounds have been identified in plant parts of sacred lotus (Nelumbo nucifera Gaertn.). To elucidate the molecular genetic basis of the terpene...
Sandhu, Marva Irfan, Hafiz Muhammad Shah, Shahid Ali Ahmed, Madiha Naz, Iffat Akram, Muhammad Fatima, Humaira Farooq, Ayesha Shuja
Published in
Molecules (Basel, Switzerland)
Oxidative stress (OS) and c-Jun N-terminal kinase (JNK) are both key indicators implicated in neuro-inflammatory signalling pathways and their respective neurodegenerative diseases. Drugs targeting these factors can be considered as suitable candidates for treatment of neuronal dysfunction and memory impairment. The present study encompasses benefi...
Imbault, Virginie Dionisi, Chiara Naeije, Gilles Communi, David Pandolfo, Massimo
Published in
Frontiers in Neuroscience
Clinical trials in rare diseases as Friedreich ataxia (FRDA) offer special challenges, particularly when multiple treatments become ready for clinical testing. Regulatory health authorities have developed specific pathways for “orphan” drugs allowing the use of a validated biomarker for initial approval. This study aimed to identify changes in cere...
Chai, Keping Zhang, Xiaolin Chen, Shufang Gu, Huaqian Tang, Huitao Cao, Panlong Wang, Gangqiang Ye, Weiping Wan, Feng Liang, Jiawei
...
Published in
Frontiers in Aging Neuroscience
Aberrant deposits of neurofibrillary tangles (NFT), the main characteristic of Alzheimer's disease (AD), are highly related to cognitive impairment. However, the pathological mechanism of NFT formation is still unclear. This study explored differences in gene expression patterns in multiple brain regions [entorhinal, temporal, and frontal cortex (E...
