sukhorukov, vladimir s. baranich, tatiana i. egorova, anna v. akateva, anastasia v. okulova, kseniia m. ryabova, maria s. skvortsova, krisitina a. dmitriev, oscar v. mudzhiri, natalia m. voronkov, dmitry n.
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Mitochondrial dynamics significantly play a major role in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. The dysregulation of mitochondrial biogenesis and function, characterized by impaired fission and fusion processes mediated by a number of proteins, in particular, Drp1, Mfn1, Mfn2, Opa1, and...
wang, ping okada-rising, starlyn scultetus, anke h. bailey, zachary s.
Traumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction, including oxidative stress, coagulopathy, neuroinflammation, neurodegeneration, neurotoxicity, and bloo...
perdaens, océane van pesch, vincent
Neurodegeneration is preeminent in many neurological diseases, and still a major burden we fail to manage in patient’s care. Its pathogenesis is complicated, intricate, and far from being completely understood. Taking multiple sclerosis as an example, we propose that neurodegeneration is neither a cause nor a consequence by itself. Mitochondrial dy...
munteanu, constantin onose, gelu rotariu, mariana poștaru, mădălina turnea, marius galaction, anca irina
Microbiota-derived hydrogen sulfide (H2S) plays a crucial role in modulating the gut–brain axis, with significant implications for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. H2S is produced by sulfate-reducing bacteria in the gut and acts as a critical signaling molecule influencing brain health via various pathways, including ...
bej, erjola cesare, patrizia d’angelo, michele volpe, anna rita castelli, vanessa
Aging is a natural process that leads to time-related changes and a decrease in cognitive abilities, executive functions, and attention. In neuronal aging, brain cells struggle to respond to oxidative stress. The structure, function, and survival of neurons can be mediated by different pathways that are sensitive to oxidative stress and age-related...
hayden, melvin r.
The microvessel neurovascular unit, with its brain endothelial cells (BEC) and blood–brain barrier remodeling, is important in the development of impaired cognition in sporadic or late-onset Alzheimer’s disease (LOAD), which is associated with aging and is highly prevalent in older populations (≥65 years of age). It is also linked with vascular dem...
sidoryk-węgrzynowicz, marta adamiak, kamil strużyńska, lidia
The abnormal deposition and intercellular propagation of disease-specific protein play a central role in the pathogenesis of many neurodegenerative disorders. Recent studies share the common observation that the formation of protein oligomers and subsequent pathological filaments is an essential step for the disease. Synucleinopathies such as Parki...
Garces-Davila, Isabel Stewart-Tufescu, Ashley Linton, Janice McCarthy, Julie-Anne Gill, Sonya Ciochon Newton, Aleksandra Salmon, Samantha Taillieu, Tamara Afifi, Tracie O
Published in
International journal of environmental research and public health
Physical punishment is the most common form of violence against children worldwide and is associated with an increased risk of long-term adverse outcomes. Interventions targeting parents/caregivers are frequently implemented to prevent and reduce the use of physical punishment. This scoping review aimed to map the existing literature on evidence-in...
Ben Shaul, Tal Frenkel, Dan Gurevich, Tanya
Published in
International journal of molecular sciences
Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-relate...
kola, arian vigni, ginevra lamponi, stefania valensin, daniela
Rosemary extract (Rosmarinus officinalis) is a natural source of bioactive compounds with significant antioxidant properties. Among these, rosmarinic acid is celebrated for its potent antioxidant, anti-inflammatory, antimicrobial, and neuroprotective properties, making it a valuable component in both traditional medicine and modern therapeutic rese...
