V okviru magistrske naloge smo želeli preveriti ali citotoksični fragment Aβ(25-35) vpliva na izražanje gena za (pro)katepsin X v celični liniji PC-12. Celična linija PC-12 predstavlja dober model za preučevanje nevrodegeneracije, saj izraža tudi katepsin X v neaktivni obliki prokatepsina X, ki se nahaja v lizosomih. Nediferencirane celice PC-12 sm...
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson&rsquo / s disease (PD), BDNF enhances the survival of dopaminergic neurons, improves dopaminergic neurotransmission and motor performance. Pharmacological therapies of PD are symptom-targeting, and their effectiveness decreases wit...
Alzheimer&rsquo / s disease (AD) is a progressive neurodegenerative disorder and is the most common form of dementia in the elderly. Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase-6 is considered to be an up-stream modulator of AD pathogenesis as active caspase-6 is abundant in neuropil threads,...
The intricate relationships between innate immunity and brain diseases raise increased interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders. Barriers, such as the blood&ndash / brain barrier, and innate immunity cells such as microglia, astrocytes, macrophages, and mast cells are involved in triggering disease event...
Parkinson&rsquo / s disease is caused due to the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Presently, with the exponential growth of the aging population across the world the number of people being affected by the disease is also increasing and it imposes a huge economic burden on the governments. However...
International audience
Published in Acta Neuropathologica Communications
Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. Such propagation of pathology is thought to be mediated by tau species (“seeds”) containing the microtubule bind...
Published in Journal of neuroscience research
Aging is a primary risk factor for fatal neurodegenerative disorders, yet the mechanisms underlying physiological healthy aging and pathological aging, and how these mechanisms can divert one scenario to the other, are not completely understood. In recent years, reports indicate that alterations in nucleocytoplasmic transport may be a hallmark of b...
Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely st...
The dynamic properties of mitochondria—including their fusion, fission, and degradation—are critical for their optimal function in energy generation. The interplay of fusion and fission confers widespread benefits on mitochondria, including efficient transport, increased homogenization of the mitochondrial population, and efficient oxidative phosph...
