Gould, Stacey
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful neuropathies and preclinical evidence suggests it is...
Lee, Bohm Cho, Yongcheol
Published in
International journal of molecular sciences
Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon reg...
Asiain, David Antolín, Diego
Published in
Sensors (Basel, Switzerland)
This paper presents a wireless traffic flow detection system, mainly focused on conditions in which the traffic flow is slow or stopped, which increases the risk of highway accidents. To achieve this goal, a Low Power Wide Area Network (LPWAN) based on LoRa called Short LoRa has been developed. This LoRa sub-network complies with the European Telec...
Santagostino, Sara Francesca Spinazzi, Marco Radaelli, Enrico
Published in
Veterinary pathology
Fluorescein-derived fluorochromes and anionic dyes such as Fluoro-Jade (FJ) stains have been introduced to facilitate recognition of dying neurons in tissue sections. However, the definition of what is really detected by FJ-based stains and its sensitivity in the detection of neuronal cell death is unclear. In our work, we evaluated the outcome of ...
Tao, Ling-Xue Ji, Sha-Sha Szalóki, Dóra Kovács, Tibor Mándi, Attila Antus, Sándor Ding, Xun Kurtán, Tibor Zhang, Hai-Yan
Published in
Acta pharmacologica Sinica
Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneration. Here, we provide the first demonstration that the chiral nonracemic isochroman-2H-chromene conjugate JE-133, a novel synthetic 1,3-disubst...
Srpova, Barbora Uher, Tomas Hrnciarova, Tereza Barro, Christian Andelova, Michaela Michalak, Zuzanna Vaneckova, Manuela Krasensky, Jan Noskova, Libuse Havrdova, Eva Kubala
...
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Serum neurofilament light chain (sNfL) is a marker of neuroaxonal injury. There is a lack of studies investigating the dynamics of relationships between sNfL levels and radiological disease activity over long-term follow-up in multiple sclerosis (MS). To investigate the relationship among repeated measures of sNfL, lesion burden accumulation, brain...
Zhao, Yi Ficek, Bronte Webster, Kimberly Frangakis, Constantine Caffo, Brian Hillis, Argye E Faria, Andreia Tsapkini, Kyrana
Published in
Neurorehabilitation and neural repair
Transcranial direct current stimulation (tDCS), in conjunction with language therapy, improves language therapy outcomes in primary progressive aphasia (PPA). However, no studies show whether white matter integrity predicts language therapy or tDCS effects in PPA. We aimed to determine whether white matter integrity, measured by diffusion tensor im...
Mosca, Laura Pagano, Martina Pecoraro, Annalisa Borzacchiello, Luigi Mele, Luigi Cacciapuoti, Giovanna Porcelli, Marina Russo, Giulia Russo, Annapina
Published in
International journal of molecular sciences
In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in ...
Xue, Chen Gu, Xinyu Li, Ganglei Bao, Zhengyi Li, Lanjuan
Published in
International journal of molecular sciences
Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease. Necroptosis is a common form of programmed cell death in the liver. Necroptosis can be activated by ligands of death receptors, which then interact with receptor-interactive protein kinases 1 (RIPK1). RIPK1 mediates recept...
Arslan Hafeez, Muhammad Usman, Muhammad Umer, Malik Adeel Hanif, Asad
Published in
Polymers
Magnetorheological elastomers (MREs) are magneto-sensitive smart materials, widely used in various applications, i.e., construction, automotive, electrics, electronics, medical, minimally invasive surgery, and robotics. Such a wide field of applications is due to their superior properties, including morphological, dynamic mechanical, magnetorheolog...