Smeeth, Demelza M Kourouzidou, Ioanna Duarte, Rodrigo R R Powell, Timothy R Thuret, Sandrine
Published in
Neuroscience
Previous studies have indicated that sex hormones such as prolactin, estradiol and testosterone may play a role in the modulation of adult hippocampal neurogenesis (AHN) in rodents and non-human primates, but so far there has been no investigation of their impact on human hippocampal neurogenesis. Here, we quantify the expression levels of the rele...
Li, Xinyue Ji, Guangyu Zhou, Juan Du, Jingyi Li, Xian Shi, Wei Hu, Yong Zhou, Wenjuan Hao, Aijun
Published in
Frontiers in Cell and Developmental Biology
The neural induction constitutes the initial step in the generation of the neural tube. Pcgf1, as one of six Pcgf paralogs, is a maternally expressed gene, but its role and mechanism in early neural induction during neural tube development have not yet been explored. In this study, we found that zebrafish embryos exhibited a small head and reduced ...
Li Puma, Domenica Donatella Piacentini, Roberto Grassi, Claudio
Published in
Frontiers in Molecular Neuroscience
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD). However, whether amyloid-β protein (Aβ)/tau accumulation impairs adult hippocampal neurogenesis and, consequently, the hippocampal circuitry, i...
Kim, Hyun Jung Park, Jung Won Lee, Jeong Ho
Published in
Frontiers in Oncology
An aggressive primary brain cancer, glioblastoma (GBM) is the most common cancer of the central nervous system in adults. However, an inability to identify its cell-of-origin has been a fundamental issue hindering further understanding of the nature and pathogenesis of GBM, as well as the development of novel therapeutic targets. Researchers have h...
Ge, Hongfei Zhang, Chao Yang, Yang Chen, Weixiang Zhong, Jun Fang, Xuanyu Jiang, Xuheng Tan, Liang Zou, Yongjie Hu, Rong
...
Published in
Frontiers in Molecular Neuroscience
Ischemic stroke has been becoming one of the leading causes resulting in mortality and adult long-term disability worldwide. Post-stroke pneumonia is a common complication in patients with ischemic stroke and always associated with 1-year mortality. Though ambroxol therapy often serves as a supplementary treatment for post-stroke pneumonia in ische...
Li, Fang Zhang, Jie Chen, Anbao Liao, Rui Duan, Yongchun Xu, Yuwei Tao, Lili
Published in
Aging (Albany NY)
Neural stem cell (NSC) transplantation has prevailed as a promising protective strategy for cardiac arrest (CA)-induced brain damage. Surprisingly, the poor survival of neuronal cells in severe hypoxic condition restricts the utilization of this cell-based therapy. Extracellular vesicles (EVs) transfer microRNAs (miRNAs) between cells are validated...
Yang, Xuejiao Ma, Linlin Ye, Zhujing Shi, Wenyu Zhang, Liyuan Wang, Jingdong Yang, Hongying
Published in
International journal of radiation biology
Despite being a major treatment modality for brain cancer due to its efficiency in achieving cancer control, radiotherapy has long been known to cause long-term side effects, including radiation-induced cognitive impairment (RICI). Neurogenesis inhibition due to radiation-induced damage in neural stem cells (NSCs) has been demonstrated to be an imp...
Bakhshinyan, David Savage, Neil Salim, Sabra Khalid Venugopal, Chitra Singh, Sheila K
Published in
Frontiers in oncology
During embryonic development, radial glial precursor cells give rise to neural lineages, and a small proportion persist in the adult mammalian brain to contribute to long-term neuroplasticity. Neural stem cells (NSCs) reside in two neurogenic niches of the adult brain, the hippocampus and the subventricular zone (SVZ). NSCs in the SVZ are endowed w...
Serra-Almeida, Catarina Saraiva, Cláudia Esteves, Marta Ferreira, Raquel Santos, Tiago Cristóvão, Ana Clara Bernardino, Liliana
Published in
Frontiers in cell and developmental biology
C-terminal binding proteins (CtBPs) are transcriptional modulators that can regulate gene expression through the recruitment of a corepressor complex composed of chromatin-modifying enzymes and transcriptional factors. In the brain, CtBPs have been described as regulators of cell proliferation, differentiation, and survival. Nevertheless, the role ...
Wu, Yuying Zhang, Xunrui Wang, Jue Jin, Guohua Zhang, Xinhua
Published in
Molecular Medicine Reports
Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein mo...