Wei, Mingxiao Feng, Shufang Zhang, Lin Wang, Chen Chu, Shasha Shi, Tianyao Zhou, Wenxia Zhang, Yongxiang
Published in
Frontiers in Pharmacology
Background: Cranial radiotherapy is clinically used in the treatment of brain tumours; however, the consequent cognitive and emotional dysfunctions seriously impair the life quality of patients. LW-AFC, an active fraction combination extracted from classical traditional Chinese medicine prescription Liuwei Dihuang decoction, can improve cognitive a...
chan, hau jun yanshree, yanshree roy, jaydeep tipoe, george lim fung, man-lung lim, lee wei
Alzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, but whether stem cells are safe and effective in hum...
Zhang, Wen-jun Luo, Chen Huang, Chao Liu, Si-cheng Luo, Hong-liang
Published in
Frontiers in Cell and Developmental Biology
Objectives: The purpose of this study is to investigate the effects of transplantation of microencapsulated neural stem cells (MC-NSCs), which downregulate the P2 × 4 receptor (P2 × 4R) overexpression and relieve neuropathic pain (NPP). Methods: Neural stem cells (NSCs) and MC-NSCs were transplanted to the injured sciatic nerve. Transmission electr...
Nawarawong, Natalie N. Thompson, K. Ryan Guerin, Steven P. Anasooya Shaji, Chinchusha Peng, Hui Nixon, Kimberly
Published in
Frontiers in Neuroscience
Hippocampal neurodegeneration is a consequence of excessive alcohol drinking in alcohol use disorders (AUDs), however, recent studies suggest that females may be more susceptible to alcohol-induced brain damage. Adult hippocampal neurogenesis is now well accepted to contribute to hippocampal integrity and is known to be affected by alcohol in human...
Shen, Yinan Liu, Feng Duan, Jiazhi Wang, Wenhan Yang, Hongru Wang, Zizhao Wang, Tailin Kong, Ying Ma, Baojin Hao, Min
...
Published in
Nano letters
Directed differentiation enables the production of a specific cell type by manipulating signals in development. However, there is a lack of effective means to accelerate the regeneration of neurons of particular subtypes for pathogenesis and clinical therapy. In this study, we find that hydroxyapatite (HAp) nanorods promote neural differentiation o...
Beyer, Felix Lüdje, Wichard Karpf, Julian Saher, Gesine Beckervordersandforth, Ruth
Published in
Frontiers in Neuroscience
In the adult central nervous system, neural stem cells (NSCs) reside in two discrete niches: the subependymal zone (SEZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). Here, NSCs represent a population of highly specialized astrocytes that are able to proliferate and give rise to neuronal and glial progeny. This ...
berlet, reed anthony, stefan brooks, beverly wang, zhen-jie sadanandan, nadia shear, alex cozene, blaise gonzales-portillo, bella parsons, blake salazar, felipe esparza
...
Stem cell transplantation with rehabilitation therapy presents an effective stroke treatment. Here, we discuss current breakthroughs in stem cell research along with rehabilitation strategies that may have a synergistic outcome when combined together after stroke. Indeed, stem cell transplantation offers a promising new approach and may add to curr...
kowalski, robert pikul, piotr lewandowski, krzysztof sakowicz-burkiewicz, monika pawełczyk, tadeusz zyśk, marlena
Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid. Further N-acetylaspartate pathways are still being elucidated, although they seem to involve neuron-glia crosstalk. Together with N-acetylaspartate, NAT8L takes part in oligoglia and astr...
de la cal, alejandro torrillas paniagua-torija, beatriz arevalo-martin, angel faulkes, christopher guy jiménez, antonio jesús ferrer, isidre molina-holgado, eduardo garcia-ovejero, daniel
In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in humans, the central canal is lost in the majority of individuals from early childhood. It is replaced...
layrolle, pierre payoux, pierre chavanas, stéphane
Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a master regulator of metabolism, adipogenesis, inflammation and cell cycle, and it has been extensively studied in the brain in relation to inflammation or neurodegeneration. Little is known however about its role in viral infections of the brain parenchyma, although they represent the mo...
