Su, Yixun Zhang, Wenjun Patro, C. Pawan K. Zhao, Jing Mu, Tianhao Ma, Zhongnan Xu, Jianqiang Ban, Kenneth Yi, Chenju Zhou, Yi
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Published in
Frontiers in Cell and Developmental Biology
The proliferation and differentiation of neural progenitor lay the foundation for brain development. In neural progenitors, activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been found to promote proliferation and astrocytogenesis while suppressing neurogenesis. However, our study found that Stat3 conditional knockout in ...
Coolen, Marion Labusch, Miriam Mannioui, Abdelkrim Bally-Cuif, Laure
Published in
Current biology : CB
Although developmental mechanisms driving an increase in brain size during vertebrate evolution are actively studied, we know less about evolutionary strategies allowing accelerated brain growth. In zebrafish and other vertebrates studied to date, apical radial glia (RG) constitute the primary neurogenic progenitor population throughout life [1]; t...
Ta, Aaron Chuong
Amphibian metamorphosis is a transitional period that involves significant changes in the cell type populations and biological processes occurring in the brain. However, gene expression dynamics during this process are not as well-studied as they are in earlier development. To rectify this, we sought to quantify gene expression in the X. laevis bra...
Abdusselamoglu, Merve Deniz Eroglu, Elif Burkard, Thomas R Knoblich, Jürgen A
Published in
eLife
Neural progenitors undergo temporal patterning to generate diverse neurons in a chronological order. This process is well-studied in the developing Drosophila brain and conserved in mammals. During larval stages, intermediate neural progenitors (INPs) serially express Dichaete (D), grainyhead (Grh) and eyeless (Ey/Pax6), but how the transitions are...
Hutchinson, Elizabeth B Chatterjee, Mitali Reyes, Laura Djankpa, Francis T Valiant, William G Dardzinski, Bernard Mattapallil, Joseph J Pierpaoli, Carlo Juliano, Sharon L
Published in
The Journal of comparative neurology
Although initial observations of infections with the Zika virus describe a mild illness, more recent reports show that infections by Zika result in neurotropism. In 2015, substantial congenital malformations were observed, with numerous infants born with microcephaly in Brazil. To study the underlying mechanism and effects of the disease, it is cri...
Clark, Brian S Stein-O'Brien, Genevieve L Shiau, Fion Cannon, Gabrielle H Davis-Marcisak, Emily Sherman, Thomas Santiago, Clayton P Hoang, Thanh V Rajaii, Fatemeh James-Esposito, Rebecca E
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Published in
Neuron
Precise temporal control of gene expression in neuronal progenitors is necessary for correct regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of the developing CNS has posed a major obstacle to identifying the gene regulatory networks that control these processes. To address this, we used single-cell RNA s...
Ma, Lin Wang, Yiran Hui, Yi Du, Yanhua Chen, Zhenyu Feng, Hexi Zhang, Shuwei Li, Nan Song, Jianren Fang, Yujiang
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Published in
Stem Cell Reports
In this article, Zhang and colleagues show that WNT/CTNNB1 signaling regulates the maintenance versus neurogenesis of human MGE progenitors through transcriptional activation of NOTCH signaling pathway. The regulation of WNT/NOTCH signaling cascade may thus contribute to large-scale expansion of functional MGE progenitors for cell therapies of rela...
Zholudeva, Lyandysha V Lane, Michael A
Published in
Cell transplantation
Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise overview and discussion of five key themes that have become important considerations for rebuilding functional neural networ...
Moffat, Jeffrey J Jung, Eui-Man Ka, Minhan Smith, Amanda L Jeon, Byeong Tak Santen, Gijs W E Kim, Woo-Yang
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Haploinsufficiency of the chromatin remodeling factor ARID1B leads to autism spectrum disorder and intellectual disability. Several independent research groups, including our own, recently examined the effects of heterozygous deletion of Arid1b in mice and reported severe behavioral abnormalities reminiscent of autism spectrum disorders and intelle...
Danesi, Claudia Keinänen, Kari Castrén, Maija L
Published in
Frontiers in synaptic neuroscience
Fragile X syndrome (FXS) is a neurodevelopmental disorder that represents a common cause of intellectual disability and is a variant of autism spectrum disorder (ASD). Studies that have searched for similarities in syndromic and non-syndromic forms of ASD have paid special attention to alterations of maturation and function of glutamatergic synapse...
