Purushothaman, Mugilarasi Sarkar, Snigdha Morita, Maho Gugger, Muriel Schmidt, Eric Morinaka, Brandon
: Cyanobactins comprise a widespread group of peptide metabolites produced by cyanobacteria that are often diversified by post-translational prenylation. Several enzymes have been identified in cyanobactin biosynthetic pathways that carry out chemically diverse prenylation reactions, representing a resource for the discovery of post-translational a...
Ramanjooloo, Avin Andersen, Raymond J Bhaw-Luximon, Archana
Published in
Future medicinal chemistry
Oceans harbor a vast biodiversity not represented in terrestrial habitats. Marine sponges have been the richest source of marine natural products reported to date, and sponge-derived natural products have served as inspiration for the development of several drugs in clinical use. However, many promising sponge-derived drug candidates have been stal...
Zhang, Yiming Shi, Shuobo
Published in
Frontiers in Bioengineering and Biotechnology
The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product sy...
Hassan Mir, Reyaz Godavari, Goutami Siddiqui, Nasir Ali Ahmad, Bilal Mothana, Ramzi A Ullah, Riaz Almarfadi, Omer M Jachak, Sanjay M Masoodi, Mubashir Hussain
Published in
Drug Design, Development and Therapy
Introduction Oleanolic acid, a pentacyclic triterpenic acid, is widely distributed in medicinal plants and is the most commonly studied triterpene for various biological activities, including anti-allergic, anti-cancer, and anti-inflammatory. Methods The present study was carried out to synthesize arylidene derivatives of oleanolic acid at the C-2 ...
Stoianovici, Robyn Brunetti, Luigi Adams, Christopher D
Published in
Journal of pharmacy practice
Hospitalizations can significantly disrupt patient sleep patterns and contribute to insomnia, which places patients at a higher risk of altered mental status as well as other complications. Despite attempts to control environmental factors, deliriogenic medications are often prescribed for the management of hospital-related insomnia. The primary ob...
Schwarz, Jenny Hubmann, Georg Rosenthal, Katrin Lütz, Stephan
Published in
Biomolecules
Over the past decade, the one strain many compounds (OSMAC) approach has been established for the activation of biosynthetic gene clusters (BGCs), which mainly encode the enzymes of secondary metabolite (SM) biosynthesis pathways. These BGCs were successfully activated by altering various culture conditions, such as aeration rate, temperature, and ...
Moore, Simon J. Lai, Hung-En Chee, Soo-Mei Toh, Ming Coode, Seth Chengan, Kameshwari Capel, Patrick Corre, Christophe de los Santos, Emmanuel LC Freemont, Paul S.
...
Published in
ACS Synthetic Biology
Prokaryotic cell-free coupled transcription–translation (TX-TL) systems are emerging as a powerful tool to examine natural product biosynthetic pathways in a test tube. The key advantages of this approach are the reduced experimental time scales and controlled reaction conditions. To realize this potential, it is essential to develop specialized ce...
Ibrahim, Sabrin R. M. Sirwi, Alaa Eid, Basma G. Mohamed, Shaimaa G. A. Mohamed, Gamal A.
Published in
Plants
Liver diseases represent a threat to human health and are a significant cause of mortality and morbidity worldwide. Autoimmune hepatitis (AIH) is a progressive and chronic hepatic inflammatory disease, which may lead to severe complications. Concanavalin A (Con A)-induced hepatic injury is regarded as an appropriate experimental model for investiga...
Lu, Yanting An, Tao Tian, Hu Gao, Xueqin Wang, Furong Wang, Shijun Ma, Ke
Published in
Frontiers in Pharmacology
Comorbidity between diabetes mellitus (DM) and depression, two chronic and devastating diseases spreading worldwide, has been confirmed by a large body of epidemiological and clinical studies. Due to the bidirectional relationship between DM and depression, this comorbidity leads to poorer outcomes in both conditions. Given the adverse effects and ...
Zhong, Sheng Wu, Bo Yang, Wenzhuo Ge, Junliang Zhang, Xiangheng Chen, Zhenghe Duan, Hao He, Zhenqiang Liu, Yibing Wang, Hongyu
...
Published in
Aging (Albany NY)
Object: This study was designed to screen ideal lead compounds and drug candidates with an inhibitory effect on PARP from the drug library (ZINC database). Results: Two effective natural compounds ZINC000003938684 and ZINC000014811844 were found to bind to PARP in the ZINC database, showing a higher binding affinity. Also, they were predicted to ha...