Wang, Xiqian Liu, Yingao Chen, Lijie Zhang, Jie Jiang, Ruoyu Zhang, Lei Yan, Han Zhang, Jie
Published in
Frontiers in Endocrinology
Introduction The prevalence of thyroid nodules and malignancies in the elderly is a growing concern. Thyroid nodules in this population have unique characteristics, requiring careful treatment strategies that balance risks and benefits. Oncocytic carcinoma of the thyroid (OCA) is a rare, aggressive subtype with diagnostic challenges. Methods This c...
Silverman, Isaac Gerber, Michael Shaykevich, Aaron Stein, Yitzchak Siegman, Alexander Goel, Sanjay Maitra, Radhashree
Published in
Frontiers in Molecular Biosciences
The RAS genes which code for KRAS, HRAS, and NRAS are three of the most frequently mutated oncogenes responsible for cancer deaths. Tumorigenesis is one of the most significant outcomes of deregulation of RAS GTPases. Although the structures have been extensively studied, there is still more to be discovered about the actual binding conformations o...
Tsujikawa, Takahiro Ohno, Kazuchika Morita, Kei-ichi Saburi, Sumiyo Mitsuda, Junichi Yoshimura, Kanako Kimura, Alisa Morimoto, Hiroki Ogi, Hiroshi Shibata, Saya
...
Published in
Frontiers in Immunology
Background In view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective study aimed to identify clinical, tumor microenvironmental, and genomic factors that are related to therapeutic response to the anti- Programmed cell death protein 1 (PD-1) antibod...
Long, Junshan Qiu, Baowei Su, Xiaoxia Zhang, Jing Dong, Qi
Published in
Frontiers in Pediatrics
Background Dubin-Johnson Syndrome (DJS) is a rare autosomal recessive genetic disorder, with most cases presenting in adolescence, but rare in newborns. Objective To investigate the clinical characteristics and treatment outcomes of DJS in a newborn. Methods We present the clinical features of a newborn diagnosed with DJS through molecular genetic ...
Anderson, Matthew Z. Dietz, Siobhan M.
Published in
mSphere
Fungi were some of the earliest organismal systems used to explore mutational processes and its phenotypic consequences on members of a species. Yeasts that cause significant human disease were quickly incorporated into these investigations to define the genetic and phenotypic drivers of virulence. Among Candida species, Candida albicans has emerge...
Siering, Oliver Langbein, Mareike Herrmann, Maike Wittwer, Kevin von Messling, Veronika Sawatsky, Bevan Pfaller, Christian K.
Published in
Journal of Virology
When viruses encounter a new host, they can rapidly adapt to this host and cause disease. How these adaptation processes occur remains understudied. Morbilliviruses have high clinical and veterinary relevance and are attractive model systems to study these adaptation processes. The canine distemper virus is of particular interest, as it exhibits a ...
Siering, Oliver Langbein, Mareike Herrmann, Maike Wittwer, Kevin von Messling, Veronika Sawatsky, Bevan Pfaller, Christian K.
Published in
Journal of Virology
When viruses encounter a new host, they can rapidly adapt to this host and cause disease. How these adaptation processes occur remains understudied. Morbilliviruses have high clinical and veterinary relevance and are attractive model systems to study these adaptation processes. The canine distemper virus is of particular interest, as it exhibits a ...
Xia, Xueming Du, Wei Zhang, Yan Li, Yanying Yu, Min Liu, Yongmei
Published in
Frontiers in Oncology
Objectives To explore the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) on lung adenosquamous cell carcinoma (ASC) with EGFR mutation. Methods Efficacy of EGFR-TKIs in the treatment of advanced or recurrent lung ASC with EGFR mutations was assessed retrospectively in 44 patients. Pooled analysis of 74 patients ...
Hoshino, Akihiro Picard, Benoît Heid Polychronopoulou, Sophia Kelaidi, Charikleia Azarnoush, Saba Kracker, Sven Rieux-Laucat, Frédéric Boutboul, David Latour, Sylvain
Published in
The Journal of allergy and clinical immunology
Immune dysregulation often presents as autoimmunity, inflammation, and/or lymphoproliferation. Several germline genetic defects have been associated with immune dysregulation; they include heterozygous gain-of-function (GOF) mutations in IKZF1, an essential transcription factor for hematopoiesis containing zinc finger domains (ZFs). However, in a l...
Heimlich, J Brett Raddatz, Michael A Wells, John Vlasschaert, Caitlyn Olson, Sydney Threadcraft, Marcus Foster, Kristoff Boateng, Emmanuel Umbarger, Kelsey Su, Yan Ru
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BackgroundClonal hematopoiesis of indeterminate potential (CHIP) occurs due to acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of atherosclerotic cardiovascular disease. However, there are limited data regarding specific cardiovascular phenotypes. The purpose of this study was to define the coronary artery disease phe...
