Xiong, Wenjie Wang, Zanzan Wang, Tingyu Yu, Ying Huang, Yanshan Sun, Hao Chen, Jiawen Lyu, Rui Wang, Huijun Yan, Yuting
...
Published in
Frontiers in Immunology
Introduction Minimal residual disease (MRD) has been recognized as an important prognostic factor of survival in patients with hematological malignancies. However, the prognostic value of MRD in Waldenström macroglobulinemia (WM) remains unexplored. Methods We analyzed 108 newly diagnosed WM patients receiving systematic therapy and assessed for MR...
Buccisano, Francesco Palmieri, Raffaele Guzman, Monica L. Galimberti, Sara
Published in
Frontiers in Oncology
Tecchio, Cristina Russignan, Anna Krampera, Mauro
Published in
Frontiers in Oncology
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers a survival benefit to adult patients affected by acute lymphoblastic leukemia (ALL). However, to avoid an overt disease relapse, patients with pre or post transplant persistence or occurrence of measurable residual disease (MRD) may require cellular or pharmacological interventio...
Wang, Chunyan Zhu, Li Liu, Songya Yi, Shujuan Xiao, Min Zhang, Yicheng Mao, Xia
Published in
Frontiers in Medicine
Background The diagnosis of AITL is challenging. It may be delayed or even missed due to critical clinical conditions and its histologic and immunophenotypic overlap with other neoplastic and reactive lymphoid proliferations. Objective The key objective is to obtain an efficient diagnosis, sensitive disease monitoring and treatment efficacy assessm...
Canellas, Maria Clara Bruno-Riscarolli, Enrico Ferreira-Facio, Cristiane S Lopes-Alves, Daiana V Botafogo, Vitor D Sutter, Deborah Pontes, Roberia M Land, Marcelo G P Bedran Milito, Cristiane da Costa, Elaine Sobral
...
Published in
Cancer reports (Hoboken, N.J.)
This study aims to describe immunophenotypic explorations at diagnosis and follow up of a pediatric patient with leukemic phase of ALK+ anaplastic large cell lymphoma (ALCL) by multiparametric flow cytometry (MFC). An 8-color MFC combination of antibodies allowed to identify neoplastic cells in concentrations until 0.02% during minimal residual dis...
Mestrum, Stefan G C Vanblarcum, Roanalis B Y Drent, Roosmarie J M Boonen, Bert T van Hemert, Wouter L W Ramaekers, Frans C S Hopman, Anton H N Leers, Math P G
Published in
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Recent developments in clinical flow cytometry allow the simultaneous assessment of proliferative and anti-apoptotic activity in the different hematopoietic cell lineages and during their maturation process. This can further advance the flow cytometric diagnosis of myeloid malignancies. In this study we established indicative reference values for t...
gross, noa
Surface antigens are commonly used in flow cytometry assays for the diagnosis of multiple myeloma (MM). Some of these are directly involved in MM pathogenesis or interactions with the microenvironment, but most are used for either diagnostic or prognostic purposes. In a previous study, we showed that in-vitro, CD24-positive plasma cells exhibit a l...
He, Chen Zhang, Qiu-Tang Tang, Ping Sun, Hui
Published in
Zhongguo shi yan xue ye xue za zhi
多参数流式细胞术可检测出急性髓系白血病的多种异常免疫表型，根据白血病细胞抗原表达特点建立的本实验室十色抗体组合方案能很好地检测白血病微小残留病，预测复发.
zhong;, pengqiang
We developed an artificial intelligence (AI) model that evaluates the feasibility of AI-assisted multiparameter flow cytometry (MFC) diagnosis of acute leukemia. Two hundred acute leukemia patients and 94 patients with cytopenia(s) or hematocytosis were selected to study the AI application in MFC diagnosis of acute leukemia. The kappa test analyzed...
Deben, Debbie S van Adrichem, Arjan J Drent, Roosmarie Puts, Sabine Pelzer, Kelly E J M van Bodegraven, Adriaan A Wong, Dennis R Leers, Mathie P G
Published in
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Thiopurine derivatives, such as azathioprine and mercaptopurine, are standard conventional treatment options in inflammatory bowel disease (IBD). Unfortunately, approximately half of patients discontinue thiopurine therapy within 2 years. To improve the prediction of clinical effectiveness, thiopurine therapy is currently optimized using therapeuti...
