Mules, Thomas C Vacca, Francesco Cait, Alissa Yumnam, Bibek Schmidt, Alfonso Lavender, Brittany Maclean, Kate Noble, Sophia-Louise Gasser, Olivier Camberis, Mali
...
Published in
International journal of molecular sciences
Infecting humans with controlled doses of small intestinal helminths, such as human hookworm, is proposed as a therapy for the colonic inflammatory disease ulcerative colitis. Strengthening the colonic mucus barrier is a potential mechanism by which small intestinal helminths could treat ulcerative colitis. In this study, we compare C57BL/6 mice in...
stremmel, wolfgang weiskirchen, ralf
Intestinal mucus serves as the first line barrier within the mucosa to protect against microbiota attack due to its water-repellent properties, which are the result of the high abundance of phosphatidylcholine bound to mucins. A deficiency of mucus phosphatidylcholine predisposes it to mucosal inflammation by the attack of commensal microbiota, as ...
gambino, gaetana da pozzo, eleonora salvetti, alessandra rossi, leonardo
Biological evolution has generated a vast array of natural compounds produced by organisms across all domains. Among these, secondary metabolites, selected to enhance an organism’s competitiveness in its natural environment, make them a reservoir for discovering new compounds with cytotoxic activity, potentially useful as novel anticancer agents. S...
ferri, anita simonini, roberto sabia, carla iseppi, ramona
Antimicrobial resistance is a critical global health issue, with rising resistance among bacteria and fungi. Marine organisms have emerged as promising, but underexplored, sources of new antimicrobial agents. Among them, marine polychaetes, such as Halla parthenopeia, which possess chemical defenses, could attract significant research interest. Thi...
Schaub, Aline David, Shannon C. Glas, Irina Klein, Liviana K. Violaki, Kalliopi Terrettaz, Céline Motos, Ghislain Bluvshtein, Nir Luo, Beiping Pohl, Marie
...
Published in
mSphere
This study investigates how the composition of respiratory fluids affects the stability of viruses in exhaled droplets. Understanding virus stability in droplets is important as it impacts how viruses spread and how we can combat them. We focus on influenza A virus (IAV) and investigate how different organic compounds found in lung fluid and nasal ...
Segui-Perez, Celia de Jongh, Rivka Jonkergouw, Robin L. W. Pelayo, Paula Balskus, Emily P. Zomer, Aldert Strijbis, Karin
Published in
mBio
Bacterial vaginosis (BV) is a common vaginal infection that affects a significant proportion of women and is associated with reduced fertility and increased risk of secondary infections. Gardnerella vaginalis is the most well-known BV-associated bacterium, but Prevotella species including P. timonensis and P. bivia may also play an important role. ...
Schaus, Sadie R. Vasconcelos Pereira, Gabriel Luis, Ana S. Madlambayan, Emily Terrapon, Nicolas Ostrowski, Matthew P. Jin, Chunsheng Henrissat, Bernard Hansson, Gunnar C. Martens, Eric C.
...
Published in
mBio
An important facet of maintaining healthy symbiosis between host and intestinal microbes is the mucus layer, the first defense protecting the epithelium from lumenal bacteria. Some gut bacteria degrade the various components of intestinal mucins, but detailed mechanisms used by different species are still emerging. It is imperative to understand th...
Walls, Amanda C van Vegchel, Manon Lakey, Abigail Gauri, Hemali Dixon, Joshua Ferreira, Laís A Tandon, Ishita Balachandran, Kartik
Published in
Biofabrication
The function of a well-differentiated nasal epithelium is largely affected by airflow-induced wall shear stress, yet few in vitro models recapitulate this dynamic condition. Models which do expose cells to airflow exclusively initiate flow after the differentiation process has occurred. In vivo, basal cells are constantly replenishing the epitheliu...
Meldrum, Oliver W Donaldson, Gavin C Narayana, Jayanth Kumar Ivan, Fransiskus Xaverius Jaggi, Tavleen K Mac Aogáin, Micheál Finney, Lydia J Allinson, James P Wedzicha, Jadwiga A Chotirmall, Sanjay H
...
Published in
American journal of respiratory and critical care medicine
Rationale: Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung function decline relates to mucus properties and the microbiome in COPD. Objectives: Longitudinal assessment of mucus and microbiome changes accompanying accelerated lung function dec...
Bradley, Brianna Escobedo, Carlos
Published in
Frontiers in Microbiology
Magnetotactic bacteria (MTB) are promising candidates for use as biomicrorobots in biomedical applications due to their motility, self-propulsion, and the ability to direct their navigation with an applied magnetic field. When in the body, the MTB may encounter non-Newtonian fluids such as blood plasma or mucus. However, their motility and the effe...
