Takashi, Yuko Tomita, Kazuo Kuwahara, Yoshikazu Roudkenar, Mehryar Habibi Roushandeh, Amaneh Mohammadi Igarashi, Kento Nagasawa, Taisuke Nishitani, Yoshihiro Sato, Tomoaki
Published in
Free radical biology & medicine
Most anti-cancer agents and radiotherapy exert their therapeutic effects via the production of free radicals. Ferroptosis is a recently described cell death process that is accompanied by iron-dependent lipid peroxidation. Hydrogen peroxide (H2O2) has been reported to induce cell death. However, it remains controversial whether H2O2-induced cell de...
Marten, Lara M. Brinkert, Florian Smith, Desirée E.C. Prokisch, Holger Hempel, Maja Santer, René
Published in
Molecular Genetics and Metabolism Reports
AARS1 deficiency belongs to the group of disorders affecting aminoacyl-tRNA synthetases. To date, AARS1 deficiency has only been linked to neurologic disorders. We report a 6-year-old girl with microcephaly and developmental delay who presented with repeated episodes of acute liver failure. Whole-exome sequencing revealed compound heterozygosity fo...
Li, Yi Feng, Yu-Fan Liu, Xiao-Tian Li, Yu-Chen Zhu, Hui-Min Sun, Meng-Ru Li, Ping Liu, Baolin Yang, Hua
Published in
Redox Biology
• Mitochondrial ROS increased calcium influx through CRAC channels. • Nrf2 interacted with PGC-1α to regulate mitochondrial biogenesis. • Songorine activated Nrf2 by promoting Keap1 degradation. • Songorine regulated Nrf2/ARE and PGC-1α cascades to protect cardiac function.
Pick, Elah
Published in
Redox Biology
• NEDD8/Rub1 is a key regulator of cellular redox homeostasis. • Ascomycota species that produce mitochondria-derived ROS during glycolysis require NEDD8/Rub1for viability. • NEDD8/Rub1 essentiality correlates with the existence of NEDP1 in the organism genome.
Xu, Limei Wu, Tingting Lu, Shihua Hao, Xiaohe Qin, Junchao Wang, Jing Zhang, Xiyu Liu, Qiao Kong, Beihua Gong, Yaoqin
...
Published in
Redox biology
Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecular mechanisms governing the redox homeostasis in ovarian cancer cells remain to be fully elucidated...
Missiroli, Sonia Perrone, Mariasole Genovese, Ilaria Pinton, Paolo Giorgi, Carlotta
Published in
EBioMedicine
Mitochondria are dynamic organelles that have essential metabolic activity and are regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that orchestrate key biological pathways. However, mitochondria can influence all processes linked to oncogenesis, starting from malignant transformation to metastatic dissemination...
Kaltenecker, Doris Spirk, Katrin Ruge, Frank Grebien, Florian Herling, Marco Rupprecht, Anne Kenner, Lukas Pohl, Elena E. Mueller, Kristina M. Moriggl, Richard
...
Published in
Molecular Metabolism
• Impaired temperature maintenance in mice deficient in adipocyte STAT5 after acute cold exposure. • Blocked β3-adrenergic induction of lipolysis and PKA activity in BAT upon STAT5 deficiency. • Reduced respiratory capacity in primary differentiated brown adipocytes lacking STAT5. • Diminished brown remodeling of STAT5 deficient ScWAT after chronic...
Rosen, Julia Jakobs, Philipp Ale-Agha, Niloofar Altschmied, Joachim Haendeler, Judith
Published in
Redox Biology
• Telomerase Reverse Transcriptase has non-canonical functions. • Telomerase Reverse Transcriptase is also present in mitochondria. • Localization of Telomerase Reverse Transcriptase depends on phosphorylation. • Telomerase Reverse Transcriptase and reactive oxygen species are interdependent.
Lewis, Caitlin J. Dixit, Bhavna Batiuk, Elizabeth Hall, Carter J. O'Connor, Matthew S. Boominathan, Amutha
Published in
Redox Biology
Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments. Allotopic expression of recoded mitochondrial genes from the nucleus has potential as a gene therapy strategy for such conditions, however progress in this field has been hampered by...
Pinho, Brígida R Duarte, Ana I Canas, Paula M Moreira, Paula I Murphy, Michael P Oliveira, Jorge M A
Published in
Free radical biology & medicine
Abnormal protein homeostasis (proteostasis), dysfunctional mitochondria, and aberrant redox signalling are often associated in neurodegenerative disorders, such as Huntington's (HD), Alzheimer's and Parkinson's diseases. It remains incompletely understood, however, how changes in redox signalling affect proteostasis mechanisms, including protein de...
