Heo, Gyu Seong Bajpai, Geetika Li, Wenjun Luehmann, Hannah P Sultan, Deborah H Dun, Hao Leuschner, Florian Brody, Steven L Gropler, Robert J Kreisel, Daniel
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Proinflammatory macrophages are important mediators of inflammation after myocardial infarction and of allograft injury after heart transplantation. The aim of this study was to image the recruitment of proinflammatory chemokine receptor 2-positive (CCR2+) cells in multiple heart injury models. Methods: 64Cu-DOTA-extracellular loop 1 inverso (ECL1i...
Brody, Steven L Gunsten, Sean P Luehmann, Hannah P Sultan, Debbie H Hoelscher, Michelle Heo, Gyu Seong Pan, Jiehong Koenitzer, Jeffrey R Lee, Ethan C Huang, Tao
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Published in
American journal of respiratory and critical care medicine
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease without effective molecular markers of disease activity or treatment responses. Monocyte and interstitial macrophages that express the C-C motif CCR2 (chemokine receptor 2) are active in IPF and central to fibrosis.Objectives: To phenotype patients with IPF fo...
Fevžer, Tadej
Sudhakar, Padhmanand; 139979; Verstockt, Bram; 106315; Cremer, Jonathan; Verstockt, Sare; Sabino, João; Ferrante, Marc; 45367; Vermeire, Séverine;
Crohn's disease (CD), a form of inflammatory bowel disease (IBD), is characterized by heterogeneity along multiple clinical axes, which in turn impacts disease progression and treatment modalities. Using advanced data integration approaches and systems biology tools, we studied the contribution of CD susceptibility variants and gene expression in d...
Lambour, Jennifer Naranjo-Gomez, Mar Boyer-Clavel, Myriam Pelegrin, Mireia
Gibellini, Lara De Biasi, Sara Paolini, Annamaria Borella, Rebecca Boraldi, Federica Mattioli, Marco Lo Tartaro, Domenico Fidanza, Lucia Caro-Maldonado, Alfredo Meschiari, Marianna
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Published in
EMBO molecular medicine
In patients infected by SARS-CoV-2 who experience an exaggerated inflammation leading to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we analyzed peripheral blood monocytes from patients with COVID-19 pneumonia and found that these cells show signs of altered bioenergetics and mitochondrial dysfunction, had ...
Bucşan, Allison N Williamson, Kim C
Published in
Virulence
Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have bee...
Alvarez, Karla Lucía F. Poma-Acevedo, Astrid Fernández-Díaz, Manolo
Published in
Veterinary Research
Infectious coryza (IC), an upper respiratory tract disease affecting chickens, is caused by Avibacterium paragallinarum. The clinical manifestations of IC include nasal discharge, facial swelling, and lacrimation. This acute disease results in high morbidity and low mortality, while the course of the disease is prolonged and mortality rates are inc...
Leláková, Veronika Béraud-Dufour, Sophie Hošek, Jan Šmejkal, Karel Prachyawarakorn, Vilailak Pailee, Phanruethai Widmann, Catherine Václavík, Jiří Coppola, Thierry Mazella, Jean
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Ethnopharmacological relevance: Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific. Plants of this genus have a long-standing history of use in traditional medicine for different purposes, including the treatment of inflammation. Fresh and dried le...
Ahmed, Azaz Halama, Niels
Published in
Anticancer research
Chemokine receptor inhibition is an immunotherapy that modulates the innate arm of the immune system. Previous work in microsatellite-stable metastatic colorectal cancer showed an exploitive loop that could be successfully targeted via C-C-motive-chemokine-receptor 5 (CCR5) specific blocking, resulting in a selective anti-tumoral activation of macr...
