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Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus.

Published in Emerging microbes & infections

Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like haemagglutinin, is under antibody selective pressure and may undergo antigenic change; however, its antigenic structure remains to be elucidated. In this study, we used mo...

From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment.

Published in International journal of molecular sciences

The paradigm of psoriasis as a Th17-driven disease has evolved in the last years towards a much deeper knowledge of the complex pathways, mechanisms, cells, and messengers involved, highlighting the crucial role played by the IL-17 family of cytokines. All IL-17 isoforms signal through IL-17R. Five subunits of IL-17R have been described to date, wh...

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

Published in Cell Reports

Jennewein et al. isolated 14 anti-SARS-CoV-2 neutralizing antibodies from 4 patients. One anti-S2, one anti-NTD and 11 anti-RBD. Three anti-RBD and the anti-S2 cross-neutralized SARS-CoV-1 and B.1.351. The anti-NTD mAb conferred partial protection in mice. Evolved anti-S2 antibodies may provide templates for pan-coronavirus vaccines.

Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a Phase 1 study.

Published in The Journal of allergy and clinical immunology

The efficacy of an allergen-specific IgG cocktail to treat cat allergy suggests that allergen-specific IgG may be a major protective mechanism elicited by allergen immunotherapy. Extending these findings, we tested a Bet v 1-specific antibody cocktail in birch-allergic subjects. Phase 1, randomized, double-blind, study: Part-A, ascending doses of B...

Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.

Published in The Journal of allergy and clinical immunology

Blocking the major cat allergen, Fel d 1, with monoclonal antibodies (mAbs) was effective in preventing an acute cat-allergic response. We sought to extend the allergen-specific antibody approach and demonstrate that a combination of mAbs targeting Bet v 1, the immunodominant and most abundant allergenic protein in birch pollen, can prevent the bir...

Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a Phase 1 study.

BACKGROUND: The efficacy of an allergen-specific IgG cocktail to treat cat allergy suggests that allergen-specific IgG may be a major protective mechanism elicited by allergen immunotherapy. OBJECTIVE: Extending these findings, we tested a Bet v 1-specific antibody cocktail in birch-allergic subjects. METHODS: Phase 1, randomized, double-blind, stu...

An update on the role of anti-IL-12/IL23 agents in the management of inflammatory bowel disease.

Published in British medical bulletin

The aim of treatment in inflammatory bowel disease (IBD) is to control symptoms and suppress gut inflammation with minimal systemic side effects. A large proportion of patients are either primary non-responders or lose response to currently licensed therapies. The development of monoclonal antibodies, blocking interleukin (IL)-12 and IL-23 pathways...

The Evolution of Cancer Immunotherapy.

Published in Vaccines

Immunotherapy has changed the environment of cancer treatment by providing new and efficacious therapy options for many solid and hematologic malignancies. Although not a new field of oncology, immunotherapy has quickly developed into one of the most flourishing fields in medicine. In this review article, we explore key discoveries which helped to ...

Candida Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Candida auris Invasive Infection.

Published in International journal of molecular sciences

Candida auris is a multidrug-resistant fungal pathogen that can cause disseminated bloodstream infections with up to 60% mortality in susceptible populations. Of the three major classes of antifungal drugs, most C. auris isolates show high resistance to azoles and polyenes, with some clinical isolates showing resistance to all three drug classes. W...

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human stu...

Published in Cell

Treatment with monoclonal antibody combinations limits generation of SARS-CoV-2 escape variants in humans and model animals and protects against current variants of concern.