Girault, Guillaume Freddi, Luca Jay, Maryne Perrot, Ludivine Dremeau, Alexandre Drapeau, Antoine Delannoy, Sabine Fach, Patrick Ferreira Vicente, Acacia Mick, Virginie
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Published in
Frontiers in Microbiology
Introduction Mammals are the main hosts for Brucella sp., agents of worldwide zoonosis. Marine cetaceans and pinnipeds can be infected by Brucella ceti and B. pinnipedialis, respectively. Besides classical bacteriological typing, molecular approaches such as MLVA, MLSA, and whole-genome sequencing (WGS) can differentiate these species but are cumbe...
Zhang, Ligang Deng, Ruiting Guo, Raoqing Jiang, Yawen Guan, Yichen Chen, Caiyue Zhao, Wudi Huang, Guobin Liu, Lian Du, Hongli
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Published in
Frontiers in Molecular Biosciences
Varying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading to proteotoxic and oxidative stress. Cuproptosis is highly concerned by scientific community and...
Marchand, Tony Pastoret, Cédric Damaj, Gandhi Lebouvier, Angélique Herbaux, Charles Moignet, Aline Pavlosky, Miguel Pavlosky, Astrid Blouet, Anaise Eloit, Martin
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Published in
British journal of haematology
Large granular lymphocytic (LGL) leukaemia is a rare chronic lymphoproliferative disorder characterized by an expansion of cytotoxic T or NK cells. Despite a usually indolent evolution, most patients will require a treatment over the course of the disease because of cytopenia or symptomatic associated autoimmune disorders. First-line treatment is b...
Negri, Francesca Gnetti, Letizia Aschele, Carlo
Published in
Frontiers in Oncology
Gadomski, Stephen J Mui, Byron WH Gorodetsky, Raphael Paravastu, Sriram S Featherall, Joseph Li, Li Haffey, Abigail Kim, Jae-Chun Kuznetsov, Sergei A Futrega, Kathryn
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Stem cell therapies for degenerative cartilage disease are limited by an incomplete understanding of hyaline cartilage formation and maintenance. Human bone marrow stromal cells/skeletal stem cells (hBMSCs/SSCs) produce stable hyaline cartilage when attached to hyaluronic acid-coated fibrin microbeads (HyA-FMBs), yet the mechanism remains unclear. ...
Zajacova, A. Mackova, M. Halloran, K. Gauthier, P. Balko, J. Guney, M. Rakita, D. Svorcova, M. Kolarik, J. Vachtenheim, J. Jr
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Published in
Transplant International
Qu, Meng Hou, Qinlong Yu, Chunyan Li, Xushen Xia, Jichen Dong, Zhiheng
Published in
Frontiers in Medicine
Background With the advancement of society, the cultivation of medical professionals equipped with solid theoretical knowledge, a strong sense of innovation, and critical thinking has become a crucial goal in the reform of medical higher education. Over recent years, the hybrid Problem-Based Learning (hPBL) model, a blend of Problem-Based Learning ...
Arruda, Vitória de Oliveira Filho, Luiz Ricardo Goulart Neves, Adriana Freitas
Published in
Microbiology Spectrum
Dengue is a neglected tropical disease of significant epidemiological importance in tropical and subtropical countries. Current diagnostics for this infection present challenges, such as cross-reactivity in serological tests. Finding ways to enhance the diagnosis of this disease is crucial, given the absence of specific treatments. An accurate, sim...
Spooner, Zeke T Encerrado‐Manriquez, Angela M Truong, Tina T Nicklisch, Sascha CT
We created a 2-week, dual-module summer course introducing high school students to environmental toxicology by teaching them quantitative polymerase chain reaction (qPCR) as a way to quantify gene expression of chemical defense proteins in response to exposure to environmental pollutants. During the course, students are guided through the various s...
Ewerling, Alexander May-Simera, Helen Louise
Published in
Microbiology and Molecular Biology Reviews
Cilia and the nucleus were two defining features of the last eukaryotic common ancestor. In early eukaryotic evolution, these structures evolved through the diversification of a common membrane-coating ancestor, the protocoatomer. While in cilia, the descendants of this protein complex evolved into parts of the intraflagellar transport complexes an...