Background and purpose: Cognitive decline is one of the major outcomes after stroke. We have developed and evaluated a risk predictive tool of post-stroke cognitive decline and assessed its clinical utility.Methods: In this population-based cohort, 4,783 patients with first-ever stroke from the South London Stroke Register (1995-2010) were included...
Published in Frontiers in Genetics
Mendelian randomization makes use of genetic variants as instrumental variables to eliminate the influence induced by unknown confounders on causal estimation in epidemiology studies. However, with the soaring genetic variants identified in genome-wide association studies, the pleiotropy, and linkage disequilibrium in genetic variants are unavoidab...
In clinical trials, longitudinal data are commonly analyzed and compared between groups using a single summary statistic such as area under the outcome versus time curve (AUC). However, incomplete data, arising from censoring due to a limit of detection or missing data, can bias these analyses. In this article, we present a statistical test based o...
Published in Briefings in bioinformatics
Genome-wide association studies (GWAS) using longitudinal phenotypes collected over time is appealing due to the improvement of power. However, computation burden has been a challenge because of the complex algorithms for modeling the longitudinal data. Approximation methods based on empirical Bayesian estimates (EBEs) from mixed-effects modeling h...
Published in Genetic epidemiology
Population stratification may cause an inflated type-I error and spurious association when assessing the association between genetic variations with an outcome. Many genetic association studies are now using exonic variants, which captures only 1% of the genome, however, population stratification adjustments have not been evaluated in the context o...
Published in Biomolecules
Contact and fumigation toxicity of four isothiocyanates (ITCs), including allyl isothiocyanate (AITC), 3-butenyl isothiocyanate (3BITC), 3-(methylthio) propyl isothiocyanate (3MPITC) and 2-phenylethyl isothiocyanate (2PEITC), were evaluated against the red imported fire ant worker, Solenopsis invicta Buren. 2PEITC and 3MPITC exhibited strong contac...
Published in International Journal of Environmental Research and Public Health
Interventions tackling multiple drivers of child malnutrition have potential, yet the evidence is limited and draws on different analysis and nutrition outcomes, reducing comparability. To better understand the advantages and disadvantages of three different analytical approaches on seven common nutrition indicators, we use panel data (2012, 2014, ...
Aerosol optical depth (AOD) has been widely used to estimate near-surface particulate matter (PM). In this study, ground-measured data from the Campaign on Atmospheric Aerosol Research network of China (CARE-China) and the Aerosol Robotic Network (AERONET) were used to evaluate the accuracy of Visible Infrared Imaging Radiometer Suite (VIIRS) AOD d...
Published in Frontiers in Psychology
Japanese is a clause chaining language, in which a sentence is formed by linking two or more clauses in a series (chain), using different forms of the verb in “non-final” clauses within the chain from the “final” clauses that end the chain. Since the verb comes at the end of a clause in Japanese, speakers must decide by the time they reach the verb...
Published in Topics in Linguistics
The topic of this paper is the interaction of aspectual verb coding, information content and lengths of verbs, as generally stated in Shannon’s source coding theorem on the interaction between the coding and length of a message. We hypothesize that, based on this interaction, lengths of aspectual verb forms can be predicted from both their aspectua...
