Xu, Chenling Yue, Yan Xiong, Sidong
Published in
Frontiers in Microbiology
Macrophages are the main target cells for Mycobacterium tuberculosis (Mtb) infection. Previous studies have shown that Mtb actively upregulates phosphorus transport proteins, such as Rv0928 protein (also known as PstS3), to increase inorganic phosphate uptake and promote their survival under low phosphorus culture conditions in vitro. However, it i...
Xu, Lingna Wang, Liquan Tong, Chao
Published in
Autophagy
Miga is an evolutionarily conserved protein that localizes to the outer membrane of mitochondria and mediates endoplasmic reticulum (ER)-mitochondrial contacts through interaction with VAP proteins in the ER. We recently reported that Miga is required for autophagosome-lysosome fusion during macroautophagy/autophagy. Miga binds to Atg14 and Uvrag, ...
Ivanušec, Adrijan
Sekretorne fosfolipaze A2 (sPLA2) so ena od družin fosfolipaz A2, encimov, ki katalizirajo hidrolizo estrske vezi v glicerofosfolipidu na mestu sn-2, pri čemer se sprostita prosta maščobna kislina in lizofosfolipid. Vendar pa sPLA2 lahko delujejo tudi kot ligandi za raznolike proteinske receptorje, zato je njihova (pato)fiziologija kompleksna in kl...
Hao, Shuai Huang, Miao Xu, Xiaofan Wang, Xulin Song, Yuqing Jiang, Wendi Huo, Liqun Gu, Jun
Published in
Frontiers in Immunology
Background Owing to the complex pathophysiological features and heterogeneity of sepsis, current diagnostic methods are not sufficiently precise or timely, causing a delay in treatment. It has been suggested that mitochondrial dysfunction plays a critical role in sepsis. However, the role and mechanism of mitochondria-related genes in the diagnosti...
Zhu, Wen Zhang, Wen Yang, Feng Cai, Min Li, Xiangting Xiang, Yijin Xiang, Jun Yang, Yunke Cai, Dingfang
Published in
Frontiers in Neurology
Depression is the most prevalent psychiatric disorder, which needs deeper mechanism research studies and effective therapy. Zi-Shui-Qing-Gan-Yin (ZSQGY) is a traditional Chinese medicine decoction that has been widely used in China in the treatment of depressive symptoms. The aim of the study was to examine the anti-depressive effects of ZSQGY and ...
Nair, Sethu C Munro, Justin T Mann, Alexis Llinás, Manuel Prigge, Sean T
Published in
Proceedings of the National Academy of Sciences of the United States of America
Coenzyme A (CoA) biosynthesis is an excellent target for antimalarial intervention. While most studies have focused on the use of CoA to produce acetyl-CoA in the apicoplast and the cytosol of malaria parasites, mitochondrial acetyl-CoA production is less well understood. In the current study, we performed metabolite-labeling experiments to measure...
Jiang, Tong Du, Kaitong Xie, Jipeng Sun, Geng Wang, Pei Chen, Xi Cao, Zhiyan Wang, Baichen Chao, Qing Li, Xiangdong
...
Published in
Cell reports
Mosaic symptoms are commonly observed in virus-infected plants. However, the underlying mechanism by which viruses cause mosaic symptoms as well as the key regulator(s) involved in this process remain unclear. Here, we investigate maize dwarf mosaic disease caused by sugarcane mosaic virus (SCMV). We find that the manifestation of mosaic symptoms i...
Wu, Mingming Cai, Maohong Zhai, Rongrong Ye, Jing Zhu, Guofu Yu, Faming Ye, Shenghai Zhang, Xiaoming
Published in
Frontiers in Plant Science
Rice kernel quality has vital commercial value. Grain chalkiness deteriorates rice’s appearance and palatability. However, the molecular mechanisms that govern grain chalkiness remain unclear and may be regulated by many factors. In this study, we identified a stable hereditary mutant, white belly grain 1 (wbg1), which has a white belly in its matu...
Koustas, Evangelos Trifylli, Eleni-Myrto Sarantis, Panagiotis Papadopoulos, Nikolaos Papanikolopoulos, Konstantinos Aloizos, Georgios Damaskos, Christos Garmpis, Nikolaos Garmpi, Anna Matthaios, Dimitris
...
Published in
Genes
Autophagy constitutes a well-known homeostatic and catabolic process that is responsible for degradation and recycling of cellular components. It is a key regulatory mechanism for several cellular functions, whereas its dysregulation is associated with tumorigenesis, tumor-stroma interactions and resistance to cancer therapy. A growing body of evid...
Li, Jingjing Yan, Bin He, Hongli Xu, Xiaoli Ruan, Yongying Yang, Maofa
Published in
Genes
In this study, the mitochondrial genome of Luperomorpha xanthodera was assembled and annotated, which is a circular DNA molecule including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA genes (12S rRNA and 16S rRNA), and 1388 bp non-coding regions (A + T rich region), measuring 16,021 bp in length. The nucleotide comp...
