Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was identified from orange-spotted g...
Cancer can be initiated in a cell or a fibroblast by the short-circuiting of the cellular electromagnetic field by various fibers, parasitic energy consumption, virus infections, and mitochondrial defects, leading to a damped cellular electromagnetic field. Except short-circuiting (e.g., by asbestos fibers), the central process is mitochondrial dys...
Neurodegenerative diseases, namely Alzheimer&rsquo / s disease (AD), Parkinson&rsquo / s disease (PD), amyotrophic lateral sclerosis, Huntington&rsquo / s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world&rsquo / s population. These diseases often share the same biological mechanis...
Glucolipotoxicity caused by hyperglycemia and hyperlipidemia are the common features of diabetes-induced complications. Metabolic adaptation, particularly in energy metabolism / mitochondrial dysfunction / and increased inflammatory and oxidative stress responses are considered to be the main characteristics of diabetes and metabolic syndrome. Howe...
Published in Insect molecular biology
Fused in sarcoma (FUS) is a DNA/RNA-binding protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. The exact molecular mechanisms by which FUS results in neurotoxicity have not yet been fully elucidated. Here, we found that parkin is a genetic suppressor of defective phenotypes induced by exogenous human ...
Glaucoma is an age related disease characterized by the progressive loss of retinal ganglion cells, which are the neurons that transduce the visual information from the retina to the brain. It is the leading cause of irreversible blindness worldwide. To gain further insights into primary open-angle glaucoma (POAG) pathophysiology, we performed a no...
Published in Journal of applied toxicology : JAT
Owing to the increasing application of engineered nanoparticles (NPs), besides the workplace, human beings are also exposed to NPs from nanoproducts through the skin, respiratory tract, digestive tract and vein injection. This review states pathways of cellular uptake, subcellular distribution and excretion of NPs. The uptake pathways commonly incl...
Acute pancreatitis (AP) is a debilitating, sometimes fatal disease, marked by local injury and systemic inflammation. Mitochondrial dysfunction is a central feature of pancreatic damage in AP, however, its involvement in circulating blood cell subtypes is unknown. This study compared mitochondrial bioenergetics in circulating leukocytes from AP pat...
Duchenne and Becker muscular dystrophies (DMD/BMD) result in progressive weakness of skeletal and cardiac muscles due to the deficiency of functional dystrophin. Respiratory failure is a leading cause of mortality in DMD patients / however, improved management of the respiratory symptoms have increased patients&rsquo / life expectancy, thereby also...
Published in Polymers
In this study, waste cotton fibers were environmentally reused. First, they were milled into fine powders with particle sizes of around 30 µm and dyed for use as pigments. Dyeing properties of the cellulose powder were explored by determining the dye uptake, K/S value, and bath ratio. Among the various samples, powders with owf (on weight of fabric...
