LeVine, Steven M
Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Chlorosis in azaleas is characterized by an interveinal yellowing of leaves that is typically caused by a deficiency of iron. This condition is usually due to the inability of cells to properly acquire iron as a consequence of unfavorable conditions, such as an elevated pH, rather than insufficient iron levels. The causes and effects of chlorosis w...
Nishida, Motohiro Mi, Xinya Ishii, Yukina Kato, Yuri Nishimura, Akiyuki
Published in
Journal of biochemistry
Morphological and structural remodeling of the heart, including cardiac hypertrophy and fibrosis, has been considered as a therapeutic target for heart failure for approximately three decades. Groundbreaking heart failure medications demonstrating reverse remodeling effects have contributed significantly to medical advancements. However, nearly 50%...
Milosevic, Tamara V Vertenoeil, Gaëlle Vainchenker, William Tulkens, Paul M Constantinescu, Stefan N Van Bambeke, Françoise
Published in
Antimicrobial agents and chemotherapy
Oxazolidinones (linezolid and tedizolid) adverse reactions include thrombocytopenia, the mechanism of which is still largely unknown. In cultured cells, oxazolidinones impair mitochondrial protein synthesis and oxidative metabolism. As mitochondrial activity is essential for megakaryocyte differentiation and maturation into platelets, we examined w...
Chen, Yan-Jun Xie, Ming-Rong Zhou, Sheng-Qiang Liu, Fang
Published in
Frontiers in Neurology
Background Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder primarily affecting the elderly. Relevant studies suggest a significant connection between the mitochondria and PD. Publications exploring this connection have steadily increased in recent years. This study employs a bibliometric approach to comprehensively ana...
Jiménez-Loygorri, Juan Ignacio Jiménez-García, Carlos Viedma-Poyatos, Álvaro Boya, Patricia
Published in
Frontiers in Cell and Developmental Biology
Mitochondrial quality control is finely tuned by mitophagy, the selective degradation of mitochondria through autophagy, and mitochondrial biogenesis. Removal of damaged mitochondria is essential to preserve cellular bioenergetics and prevent detrimental events such as sustained mitoROS production, pro-apoptotic cytochrome c release or mtDNA leakag...
Peng, Hanhan Li, Haoyu Ma, Benteng Sun, Xinyue Chen, Baihua
Published in
Frontiers in Pharmacology
Purpose This study aimed to investigate the antioxidative and neuroprotective effects of DJ-1 in mitigating retinal ganglion cell (RGC) damage induced by high glucose (HG). Methods A diabetic mouse model and an HG-induced R28 cell model were employed for loss- and gain-of-function experiments. The expression levels of apoptosis and oxidative stress...
Gay, Laetitia Desquiret-Dumas, Valérie Nagot, Nicolas Rapenne, Clara van de Perre, Philippe Reynier, Pascal Molès, Jean‐pierre
Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged. Quantitative d...
Le Bacquer, Olivier Pumain, Lilian Patrac, Véronique Saroul, Nicolas Walrand, Stéphane
Rationale: Chemotherapy-induced cachexia is a syndrome of uncontrolled muscle loss that exacerbates cancer-related cachexia. Although skeletal muscle mass is predictive of long-term survival, there are currently no defined therapeutic strategies to counteract this muscle wasting. We previously demonstrated that cannabidiol (CBD) can prevent cell de...
Mendoza, Hector Lamb, Emma A. Thomas, Joshua Tavares, Derica Goncalves Schroeder, Luke A. Müller, Christian Agrawal, Nisha Schirawski, Jan Perlin, Michael H.
Published in
Frontiers in Physiology
Introduction Modern understanding of the concept of genetic diversity must include the study of both nuclear and organellar DNA, which differ greatly in terms of their structure, organization, gene content and distribution. This study comprises an analysis of the genetic diversity of the smut fungus Sporisorium reilianum f. sp. zeae from a mitochon...
Taskintuna, Kaan Bhat, Mohd Akbar Shaikh, Tasneem Hum, Jacob Golestaneh, Nady
Published in
Frontiers in Cellular Neuroscience
Age-related macular degeneration (AMD) is a major cause of blindness that affects people over 60. While aging is the prominent factor in AMD, studies have reported a higher prevalence of AMD in women compared to age-matched men. Higher levels of the innate immune response’s effector proteins complement factor B and factor I were also found in femal...
