Whitworth, Laura Coxon, Jacob van Laarhoven, Arjan Thuong, Nguyen Thuy Thuong Dian, Sofiati Alisjahbana, Bachti Ganiem, Ahmad Rizal van Crevel, Reinout Thwaites, Guy E Troll, Mark
...
Published in
eLife
Tuberculous meningitis is a serious infection of the lining of the brain, which affects over 100,000 people a year. Without treatment, it is always fatal: even with proper antibiotics, about a quarter of patients do not survive and many will have permanent brain damage. Overactive inflammation is thought to contribute to this process. Corticosteroi...
Chaziya, Jessica Freyne, Bridget Lissauer, Samantha Nielsen, Maryke Langton, Josephine O'Hare, Bernadette Molyneux, Liz Moxon, Christopher Iroh Tam, Pui-Ying Hoskyns, Lucy
...
Published in
Archives of disease in childhood
Mukhtar, Sabrina Atta, Sarah Durrani, Asad Perera, Chandrashan Kowalski, Regis Jhanji, Vishal
Published in
The British journal of ophthalmology
To determine the degree of microbiological agreement between corneal scrapings and contact lens cultures in cases of contact lens-associated keratitis. Electronic medical records of all cases of contact lens-associated keratitis at a single institution from April 2006 to May 2019 were reviewed. Cases where both corneal scrapings and contact lens cu...
Gregorova, Michaela Morse, Daniel Brignoli, Tarcisio Steventon, Joseph Hamilton, Fergus Albur, Mahableshwar Arnold, David Thomas, Matthew Halliday, Alice Baum, Holly
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Published in
eLife
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T...
Springstein, Benjamin L Nürnberg, Dennis J Weiss, Gregor L Pilhofer, Martin Stucken, Karina
Published in
Life (Basel, Switzerland)
Cells have to erect and sustain an organized and dynamically adaptable structure for an efficient mode of operation that allows drastic morphological changes during cell growth and cell division. These manifold tasks are complied by the so-called cytoskeleton and its associated proteins. In bacteria, FtsZ and MreB, the bacterial homologs to tubulin...
Gregorova, M Morse, D Brignoli, T Steventon, J Hamilton, F Albur, M Arnold, D Thomas, M Halliday, A Baum, H
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Here we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-...
Thacker, Vivek V Dhar, Neeraj Sharma, Kunal Barrile, Riccardo Karalis, Katia McKinney, John D
Published in
eLife
We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models and to probe the direct role of pulmonary surfactant in early infection. Surfactant deficiency results in rapid...
Collins, Christine R Hackett, Fiona Howell, Steven A Snijders, Ambrosius P Russell, Matthew Rg Collinson, Lucy M Blackman, Michael J
Published in
eLife
Malaria kills or disables hundreds of millions of people across the world, especially in developing economies. The most severe form of the disease is caused by Plasmodium falciparum, a single-cell parasite which, once inside a human host, forces its way into red blood cells to feed on a protein called haemoglobin. This invasion relies on P. falcipa...
Yildiz, Soner Pereira Bonifacio Lopes, João P Bergé, Matthieu González-Ruiz, Víctor Baud, Damian Kloehn, Joachim Boal-Carvalho, Inês Schaeren, Olivier P Schotsaert, Michael Hathaway, Lucy J
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Published in
eLife
Under eubiotic conditions commensal microbes are known to provide a competitive barrier against invading bacterial pathogens in the intestinal tract, on the skin or on the vaginal mucosa. Here, we evaluate the role of lung microbiota in Pneumococcus colonization of the lungs. In eubiosis, the lungs of mice were dominantly colonized by Lactobacillus...
Gustavsson, Lars Lindquist, Simon Elfvin, Anders Hentz, Elisabet Studahl, Marie
Published in
BMJ Paediatrics Open
Introduction Excessive administration of antibiotics to preterm infants is associated with increased rates of complications. The purpose of the study was to evaluate the effect of an antimicrobial stewardship intervention on antibiotic use in extremely preterm infants. Design, setting, patients and intervention A before and after study of infants b...
