Lee, Kyung Eun Nishi, Miyuki Kim, Jongsoo Murayama, Takashi Dawson, Zachary Wang, Xiaoliang Zhou, Xinyu Tan, Tao Cai, Chuanxi Takeshima, Hiroshi
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Published in
Frontiers in Endocrinology
Rationale MG53’s known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53’s role in the development of type 2 diabetes mellitus. Objective This study aims to address this controversy – whether MG53’s myokine function contributes to inhibition of insulin s...
Guevara, Christopher A. Alloo, Kumayl Gupta, Swati Thomas, Romario del Valle, Pamela Magee, Alexandra R. Benson, Deanna L. Huntley, George W.
Published in
Frontiers in Behavioral Neuroscience
Anxiety is a psychiatric non-motor symptom of Parkinson’s that can appear in the prodromal period, prior to significant loss of midbrain dopamine neurons and motor symptoms. Parkinson’s-related anxiety affects females more than males, despite the greater prevalence of Parkinson’s in males. How stress, anxiety and Parkinson’s are related and the bas...
Wang, Lei Lu, XueRong Szalad, Alexandra Liu, Xian Shuang Zhang, Yi Wang, Xinli Golembieski, William Anthony Powell, Brianna Mccann, Mikkala Lu, Mei
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Published in
Frontiers in Cellular Neuroscience
Background MicroRNAs (miRNAs) in Schwann cells (SCs) mediate peripheral nerve function. Ablating Dicer, a key gene in miRNA biogenesis, in SCs causes peripheral neuropathy. Exosomes from healthy SCs (SC-Exo) ameliorate diabetic peripheral neuropathy in part via miRNAs. Thus, using transgenic mice with conditional and inducible ablation of Dicer in ...
Pérez, Patricia Astorgano, David Albericio, Guillermo Flores, Sara Sánchez-Corzo, Cristina Noriega, María A. Sánchez-Cordón, Pedro J. Labiod, Nuria Delgado, Rafael Casasnovas, José M.
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Published in
Frontiers in Immunology
Despite the decrease in mortality and morbidity due to SARS-CoV-2 infection, the incidence of infections due to Omicron subvariants of SARS-CoV-2 remains high. The mutations acquired by these subvariants, mainly concentrated in the receptor-binding domain (RBD), have caused a shift in infectivity and transmissibility, leading to a loss of effective...
Ukezono, Masatoshi Kasahara, Yoshiyuki Yoshida, Chihiro Murakami, Yuki Okada, Takashi Takano, Yuji
Published in
Frontiers in Behavioral Neuroscience
Background A rodent autism spectrum disorder (ASD) model based on prenatal exposure to valproic acid (VPA) is widely recognized as a prominent model. Social behavior in rodent ASD models has primarily been evaluated through a three-chamber approach test. However, in this study, we focused on social attention in the VPA model of ASD. Methods In male...
Uno, Naoko Ebensen, Thomas Guzman, Carlos A. Ross, Ted M.
Published in
Journal of Virology
Influenza is a respiratory virus which infects around a billion people globally every year, with millions experiencing severe illness. Commercial vaccine efficacy varies year to year and can be low due to mismatch of circulating virus strains. Thus, the formulation of current vaccines has to be adapted accordingly every year. The development of a b...
Barco-Tejada, Ainara López-Esteban, Rocio Mulero, Francisca Pion, Marjorie Correa-Rocha, Rafael Desco, Manuel Cussó, Lorena
Published in
Frontiers in Immunology
The use of flow cytometry in mice is constrained by several factors, including the limited availability of mouse-specific antibodies and the need to work with small volumes of peripheral blood. This is particularly challenging for longitudinal studies, as serial blood samples should not exceed 10% of the total blood volume in mice. To address this,...
Chakravarty, Esha Dorak, Mehmet T.
Published in
Frontiers in Immunology
Guzylack-Piriou, Laurence Gausseres, Blandine Tasca, Christian Hassel, Chervin Tabouret, Guillaume Foucras, Gilles
Published in
Frontiers in Immunology
Introduction The role of suppressor of cytokine signaling (SOCS)2 in anti-infective bacterial immunity has been poorly investigated compared to other members of the SOCS family. Methods We characterized the previously identified loss of function R96C point mutation of SOCS2 using a genome-edited mouse model that resumes the phenotype of Socs2 knock...
Yu, Jialu
Published in
Open Medicine
Background Neural cell damage is an important cause of exacerbation of depression symptoms caused by hypoxia, but the mechanism behind it is still unclear. The purpose of this study is to elucidate the role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)/mitofusin-2 (MFN2) signaling axis in the development of depress...
