Fan, Changru Yuan, Qiulan Liu, Guifeng Zhang, Yuliang Yan, Maojun Sun, Qingxu Zhu, Chaoyu
Published in
Cancer Cell International
BackgroundColorectal cancer (CRC) is one of the most general malignant tumors. Accumulating evidence implied that long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) participated in the tumorigenesis of CRC. However, the effect of MALAT1 in drug-resistance needed to be further illustrated.MethodsLevels of MALAT1, mic...
Liao, Xin Zhan, Wei Tian, Bin Luo, Yilin Gu, Fang Li, Rui
Published in
OncoTargets and therapy
Emerging evidence has revealed that circular RNAs (circRNAs) participated in hepatocellular carcinoma (HCC) development. However, the roles of most circRNAs have not been studied. CircZNF609, miR-342-3p and RAP2C expressions were assessed by qPCR or Western blot. Loss-of-function experiments were performed using si-circZNF609 transfection, followed...
Shi, Xinghua Huo, Jinzhi Gao, Xingping Cai, Hua Zhu, Weipei
Published in
Cancer Cell International
BackgroundCervical cancer (CC) is the 4th most common cancer-related death in gynecological cancer worldwide. It has been reported that many lncRNAs contribute to oncogenesis although the fundamental mechanisms are basically unknown. Here, we aimed to identify a novel lncRNA H1FX-AS1 and explore a ceRNA network in CC oncogenesis and progression.Met...
Fang, Xuan Zhang, Jin Li, Chunyan Liu, Jinjin Shi, Zhendong Zhou, Peng
Published in
Cancer Cell International
BackgroundIncreasing evidence has indicated the important role of long non-coding RNAs (lncRNAs) in regulating the development and progression of cancers, including triple-negative breast cancer (TNBC). Small nucleolar RNA host gene 22 (SNHG22) is a novel lncRNA that has been identified as tumor-contributor in ovarian carcinoma. However, its functi...
Wang, Xiaoqin Wang, Chunhui Xu, Hong Xie, Hong
Published in
Cancer Management and Research
Background Nasopharyngeal carcinoma (NPC), one of the most common types of head and neck tumor, occurred in the epithelial lining of the nasopharynx and is mainly prevalent in Southeast Asia and Southern China. However, the molecular mechanisms of NPC multidrug resistance still remained largely unclear. Methods The qRT-PCR assay was performed to ex...
Zhao, Tiancheng Zhang, Jiayu Ye, Cong Tian, Leilei Li, Yezhou
Published in
Cancer Cell International
BackgroundLong non-coding RNAs (lncRNAs) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) are reported could function as tumor promoter in several cancers. However, its role in hemangioma was not reported to yet.MethodsExpression level of FOXD2-AS1 in hemangioma tissues and cells was explored using quantitative reverse-time PCR. Cell counting kit-8...
Yan, Dongsheng Liu, Weidong Liu, Yeliu Luo, Man
Published in
Journal of cellular physiology
Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumor suppressor in various cancers...
Xie, Ning Fei, Xiuqu Liu, Shuliang Liao, Jie Li, Youjie
Published in
American journal of translational research
LncRNAs are played crucial roles in athogenesis of NSCLC. LOXL1-AS1 involved in development of several tumors. So far, there is no study about expression and function pattern of the LOXL1-AS1 in NSCLC. In this reference, we firstly proved that LOXL1-AS1 was overexpressed in NSCLC cell lines (H23, A549, H1299 and SPC-A1) compared to 16HBE cell. The ...
Liu, Wei Wang, Zhenglin Wang, Cong Ai, Zhilong
Published in
Cancer Cell International
BackgroundAccumulating evidences indicate that long non-coding RNAs (lncRNAs) play an important role in initiation and development of thyroid cancer. However, the underlying molecular mechanism remains elusive.MethodsTo explore potential oncogenic and tumor suppressive lncRNAs in papillary thyroid cancer (PTC), we performed RNA sequencing to discov...
Ge, Yanni Wang, Juan Wu, Dengke Zhou, Yu Qiu, Shuangfa Chen, Junxiang Zhu, Xuejin Xiang, Xudong Li, Huiling Zhang, Dongshan
...
Published in
Molecular Therapy. Nucleic Acids
Several studies have suggested that long intergenic noncoding RNAs are involved in the progression of diabetic nephropathy (DN). However, the exact role and regulatory mechanism of long noncoding RNA (lncRNA) NR_038323 in diabetic nephropathy (DN) remain largely unclear. In the present study, we found that lncRNA NR_038323 overexpression ameliorate...
