Cansanção, Kátia Citelli, Marta Carvalho Leite, Nathalie López de las Hazas, María-Carmen Dávalos, Alberto Tavares do Carmo, Maria das Graças Peres, Wilza Arantes Ferreira
Published in
Nutrients
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease affecting up to 25% of the population worldwide. n-3 long-chain polyunsaturated fatty acids (n-3 PUFA) have been associated with improved clinical parameters of NAFLD. Our purpose was to conduct a pilot study to evaluate the effects of n-3 PUFA supplementation in a randomized, double-bl...
Udesen, Pernille Bækgaard Glintborg, Dorte Sørensen, Anja Elaine Svendsen, Rikke Nielsen, Nanna Louise Skov Wissing, Marie Louise Muff Andersen, Marianne Skovsager Englund, Anne Lis Mikkelsen Dalgaard, Louise Torp
Published in
Endocrine Connections
Metformin is associated with increased insulin sensitivity, whereas oral contraceptive pills (OCP) could increase the risk for type 2 diabetes (T2D) in women with polycystic ovary syndrome (PCOS). Certain miRNAs might serve as biomarkers for the risk of T2D. The aim of this study was to investigate changes in circulating miRNA levels during treatme...
Li, Chong Lu, Lungen Qi, Zhongtian Zhu, Yongqiang Su, Fengtao Zhao, Ping Dong, Hui
Published in
Frontiers in Microbiology
Hepatitis C virus (HCV)-host cell interaction during infection disturbs cellular homeostasis and culminates in pathological consequences. The processes could be first embodied in gene expression of HCV-infected cells. Here, we investigated transcriptome and miRNA expression (miRNome) alterations in HCV-infected Huh7 cells at 12, 36, and 60 h after ...
Wang, Mingliang Zheng, Huifen Zhou, Xianbo Zhang, Jiwei Shao, Guanghui
Published in
Animal Cells and Systems
Diabetic retinopathy (DR) is a primary complication of diabetes mellitus. DR can cause severe vision loss for patients. miR-122 is elevated in DR patients, while its role in DR is unclear. Hence, the purpose of this study was to analyze the effect of miR-122 on the function of high glucose-induced REC cells and the underlying molecular mechanisms. ...
Xu, Xiqiang Chen, Yuan Tan, Bingyi Wang, Dachuan Yuan, Zenong Wang, Feng
Published in
Journal of cellular biochemistry
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that are widely expressed in human disease. However, circRNAs expression profile and potential mechanism in osteoporosis pathogenesis remain to be further studied. In the present study, a total of 69 circRNAs were identified to be abnormally expressed in osteoporosis patient samples by mi...
Sidorkiewicz, Malgorzata Grek-Kowalinska, Martyna Piekarska, Anna
Published in
Pathogens
The hepatitis C virus (HCV) is known as a main etiological cause of chronic hepatitis. HCV infection disturbs cholesterol metabolism of the host, which is frequently observed in patients suffering from chronic hepatitis C (CHC). The course of viral infections remains under strict control of microRNA (miRNA). In the case of HCV, miR-122 exerts a pos...
Bai, Yinwei Chen, Kun Zhan, Jianfeng Wu, Mingxin
Published in
Bioscience Reports
Background/Aims: MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. Methods: The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, aggrecan, matrix metalloprotei...
Fornes, Daiana Heinecke, Florencia Roberti, Sabrina Lorena White, Verónica Capobianco, Evangelina Jawerbaum, Alicia
Published in
Molecular and cellular endocrinology
In gestational diabetes mellitus (GDM) pregnancies, a compromised fetal liver may impact offspring's metabolic health. Here, we aimed to address prooxidant, proinflammatory and profibrotic markers in the livers from GDM rats and their fetuses, and to analyze the expression of miR-122 (a relevant microRNA in liver pathophysiology) in fetal and mater...
Derakhshanfar, Amin Moayedi, Javad Vahedi, Mahjoob Valizadeh, Abouzar
Published in
Microrna (Shariqah, United Arab Emirates)
Background Arum conophalloides (A. conophalloides) is a wild edible delicate plant, widely used in traditional medicine. Objective This study aimed to examine the effects of A. conophalloides extracts on biochemical, molecular, and histopathological changes in the rat. Methods Fifty adult male Sprague-Dawley rats were divided into 5 groups (10 each...
Ono, Ryuichi Yoshioka, Yusuke Furukawa, Yusuke Naruse, Mie Kuwagata, Makiko Ochiya, Takahiro Kitajima, Satoshi Hirabayashi, Yoko
Published in
Toxicology reports
Recent findings have revealed that extracellular vesicles (EVs) are secreted from cells and circulate in the blood. EVs are classified as exosomes (40-100 nm), microvesicles (50-1,000 nm) or apoptotic bodies (500-2,000 nm). EVs contain mRNAs, microRNAs, and DNAs and have the ability to transfer them from cell to cell. Recently, especially in humans...
