Wang, Shuo Chen, Jiang Li, Hongyu Qi, Xingshun Liu, Xu Guo, Xiaozhong
Published in
Technology in Cancer Research & Treatment
Background: Pancreatic cancer (PC) has a poor prognosis and is prone to liver metastasis. The KAI1/CD82 gene inhibits PC metastasis. This study aimed to explore differential metabolites and enrich the pathways in serum samples between PC and liver metastasis nude mouse models stably expressing KAI1/CD82. Methods: KAI1/CD82-PLV-EF1α-MCS-IRES-Puro ve...
Bucher, Matthew Montaniel, Kim Ramil C Myatt, Leslie Weintraub, Susan Tavori, Hagai Maloyan, Alina
Published in
Journal of developmental origins of health and disease
Obesity is a chronic condition associated with dyslipidemia and insulin resistance. Here, we show that the offspring of obese mothers are dyslipidemic and insulin resistant from the outset.Maternal and cord blood and placental tissues were collected following C-section at term. Patients were grouped as being normal weight (NW, BMI = 18-24.9) or obe...
Emmert, Hila Baurecht, Hansjörg Thielking, Frederieke Stölzl, Dora Rodriguez, Elke Harder, Inken Proksch, Ehrhardt Weidinger, Stephan
Published in
Experimental dermatology
Atopic dermatitis (AD) is driven by the interplay between a dysfunctional epidermal barrier and a skewed cutaneous immune dysregulation. As part of the complex skin barrier dysfunction, abnormalities in lipid organization and microbiome composition have been described. We set out to systematically investigate the composition of the stratum corneum ...
Danoy, Mathieu Tauran, Yannick Poulain, Stéphane Jellali, Rachid Bruce, Johanna Leduc, Marjorie Le Gall, Morgane Gilard, Francoise Kido, Taketomo Arakawa, Hiroshi
...
Published in
Biotechnology and bioengineering
Maturation of human-induced pluripotent stem cells (hiPSCs)-derived hepatocytes-like cells (HLCs) toward a complete hepatocyte phenotype remains a challenge as primitiveness patterns are still commonly observed. In this study, we propose a modified differentiation protocol for those cells which includes a prematuration in Petri dishes and a maturat...
Willette, Robert N Mangrolia, Parth Pondell, Stephen M Lee, Christopher Young Woo Yoo, Sanghee Rudoltz, Marc S Cowen, Benjamin R Welsch, Dean J
Published in
The Journal of pharmacology and experimental therapeutics
Metabolic reprogramming of the myofibroblast plays a fundamental role in the pathogenesis of fibrosing interstitial lung diseases. Here, we characterized the in vitro and in vivo metabolic and anti-fibrotic effects of IM156, an oxidative phosphorylation (OXPHOS) modulator that acts by inhibiting Protein Complex 1 (PC1). In vitro, IM156 inhibited TG...
Asselstine, Victoria Lam, Stephanie Miglior, Filippo Brito, Luiz F Sweett, Hannah Guan, Leluo Waters, Sinead M Plastow, Graham Cánovas, Angela
Published in
Journal of Animal Science
Ruminant supply chains contribute 5.7 gigatons of CO2-eq per annum, which represents approximately 80% of the livestock sector emissions. One of the largest sources of emission in the ruminant sector is methane (CH4), accounting for approximately 40% of the sectors total emissions. With climate change being a growing concern, emphasis is being put ...
Manca, Maria Laura Solini, Anna Haukka, Jani K Sandholm, Niina Forsblom, Carol Groop, Per-Henrik Ferrannini, Ele
Published in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Chronic kidney disease (CKD) shows different clinical features in Types1 (T1D) and 2 diabetes (T2D). Metabolomics have recently provided useful contribution to the identification of biomarkers of CKD progression in either form of the disease. However, no studies have so far compared plasma metabolomics between T1D and T2D in order to identify diffe...
Wang, Yan-Ping Wei, Ting Ma, Xiao Zhu, Xiao-Liang Ren, Long-Fei Zhang, Lei Ding, Fang-Hui Li, Xun Wang, Hai-Ping Bai, Zhong-Tian
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Published in
Cancer Control : Journal of the Moffitt Cancer Center
Background Although Helicobacter pylori (Hp) as high risk factor for gastric cancer have been investigated from human trial, present data is inadequate to explain the effect of Hp on the changes of metabolic phenotype of gastric cancer in different stages. Purpose Herein, plasma of human superficial gastritis (Hp negative and positive), early gas...
Tu, Can Gao, Yuan Song, Di Niu, Ming Ma, Run-ran Zhou, Ming-xi He, Xian Xiao, Xiao-he Wang, Jia-bo
Published in
Frontiers in Pharmacology
Early identification of individuals susceptible to idiosyncratic drug-induced liver injury (IDILI) is a challenging unmet demand. Diclofenac, one of the most widely available over-the-counter drugs for pain management worldwide, may induce liver dysfunction, acute liver failure, and death. Herein, we report that diclofenac-related hepatobiliary adv...
Li, Zheng-Tu Zeng, Pei-Ying Chen, Zhao-Ming Guan, Wei-Jie Wang, Tong Lin, Ye Li, Shao-Qiang Zhang, Zhi-Juan Zhan, Yang-Qing Wang, Ming-Die
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Published in
Frontiers in Medicine
Background: Diagnosing chronic pulmonary aspergillosis is a major challenge in clinical practice. The development and validation of a novel, sensitive and specific assay for diagnosing chronic pulmonary aspergillosis is urgently needed. Methods: From April 2018 to June 2019, 53 patients with chronic pulmonary aspergillosis (CPA), 32 patients with c...
