Liu, Yuechen Li, Yue Zhang, Tianpu Zhao, Huan Fan, Simiao Cai, Xuemeng Liu, Yijia Li, Zhu Gao, Shan Li, Yubo
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Published in
Molecular medicine reports
Unstable angina (UA) is a coronary disease with a high mortality and morbidity worldwide. The present study aimed to use non‑invasive techniques to identify urine biomarkers in patients with UA, so as to provide more information for the early diagnosis and treatment of the disease. Based on metabolomics, urine samples from 28 patients with UA and 2...
Harlé, Olivier Deutsch, Stephanie Niay, Jérôme Valence-Bertel, Florence Parayre, Sandrine Aubert, Julie Maillard, Marie-Bernadette Henry, Gwenaele Thierry, Anne Guédon, Eric
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Lactic acid bacteria (LAB) are largely used in coculture in food fermentations. The use of different LAB species or strains as starter can bring complementary functionalities participating to the overall quality of fermented food. Fermentation can benefit from LAB’s interactions, resulting in a more efficient fermentation. Few is known about positi...
Agahi, Fojan Juan, Cristina Font, Guillermina Juan-García, Ana
Published in
Food and Chemical Toxicology
Toxicity and metabolomic profile of ZEA, α-ZEL and β-ZEL was predicted in silico. MetaTox, SwissADME and PASS online are in silico programs helping to predict toxicity. O-glucuronidation, S-sulfation and hydrolysis products defined the metabolomic´s profile. In silico studies contribute to 3R´s principle and SDG from Agenda 2030 (WHO).
Barberini, Luigi Palmas, Francesco Fais, Maria Francesca Mereu, Rossella Noto, Antonio Fattuoni, Claudia Mais, Valerio Chiodo, Antonella Meloni, Alessandra
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Objective: Premature rupture of membranes (PROM) and preterm premature rupture of membranes (pPROM) are frequent conditions with a not fully understood multifactorial etiology. It has been suggested that infection may be the leading cause of pPROM. Metabolomics is nowadays recognized as a successful and versatile approach for the investigation of s...
Fang, Heng Zhang, Aihua Zhou, Xiaohang Yu, Jingbo Song, Qi Wang, Xijun
Published in
Frontiers of medicine
High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites. This study used the established Yang Huang syndrome (YHS) mouse model to evaluate the efficacy of geniposide (GEN). Urine metabolic data were quantified by ultraperformance liquid chromatography-tande...
Comitini, Federica Peila, Chiara Fanos, Vassilios Coscia, Alessandra
Published in
Frontiers in Pediatrics
Docosahexaenoic acid (DHA) is an essential ω-3 long-chain polyunsaturated fatty acid (LCPUFA) and represents the dominant structural fatty acid in the retina and in the brain's gray matter. Due to its active participation in the development of the nervous system, DHA is one of the most studied LCPUFA and is currently considered a critical nutrient ...
Hua, Yan Cao, Heqin Wang, Jiao He, Fengping Jiang, Guangshun
Published in
BMC Veterinary Research
BackgroundGut microbes significantly contribute to nutrient digestion and absorption, intestinal health and immunity, and are essential for the survival and environmental adaptation of wild animals. However, there are few studies on the gut microbiota of captive and wild North China leopard (Panthera pardus japonensis).ResultsA total of 10 mainly b...
Kelly, Frank J. Fussell, Julia C.
Published in
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Epidemiological research has taught us a great deal about the health effects of airborne particulate matter (PM), particularly cardiorespiratory effects of combustion-related particles. This has been matched by toxicological research to define underlying mechanistic pathways. To keep abreast of the substantial challenges that air pollution continue...
Gatto, Laurent Gibb, Sebastian Rainer, Johannes
Published in
Journal of proteome research
We present version 2 of the MSnbase R/Bioconductor package. MSnbase provides infrastructure for the manipulation, processing, and visualization of mass spectrometry data. We focus on the new on-disk infrastructure, that allows the handling of large raw mass spectrometry experiments on commodity hardware and illustrate how the package is used for el...
Yu, Wei Yang, Wei Zhao, Ming-Yan Meng, Xiang-Lin
Published in
Frontiers in Pharmacology
Chronic glomerulonephritis (CGN) as the culprit of kidney failure can increase the mortality of critically ill patients and seriously threatens people’s health all over the world. This study using metabolomics strategy is to reveal the potential therapeutic mechanism-related targets to evaluate the effects of rhein (RH) on CGN rats. Changes of seru...
