Li, Jiankun Chen, Mengyao Fan, Tianyuan Mu, Xiaohuan Gao, Jie Wang, Ying Jing, Teng Shi, Cuilan Niu, Hongbin Zhen, Sihan
...
Published in
Journal of experimental botany
Multiple disease resistance (MDR) in maize has attracted increasing attention. However, the interplay between cell death and metabolite changes and their contributions to MDR remains elusive in maize. In this study, we identified a mutant named as lesion mimic 30 (les30) that showed 'suicidal' lesion formation in the absence of disease and had enha...
Ala-Korpela, Mika Zhao, Siyu Järvelin, Marjo-Riitta Mäkinen, Ville-Petteri Ohukainen, Pauli
Published in
International journal of epidemiology
Quantitative lipoprotein analytics using nuclear magnetic resonance (NMR) spectroscopy is currently commonplace in large-scale studies. One methodology has become widespread and is currently being utilized also in large biobanks. It allows the comprehensive characterization of 14 lipoprotein subclasses, clinical lipids, apolipoprotein A-I and B. Th...
Kocheril, Philip A Moore, Shepard C Lenz, Kiersten D Mukundan, Harshini Lilley, Laura M
Published in
Biomarker Insights
Traumatic brain injury (TBI) is not a single disease state but describes an array of conditions associated with insult or injury to the brain. While some individuals with TBI recover within a few days or months, others present with persistent symptoms that can cause disability, neuropsychological trauma, and even death. Understanding, diagnosing, a...
Repas, Jernej
Presnovne spremembe in izogibanje imunskemu sistemu so temeljne lastnosti raka. Metformin in 2-deoksi-D-glukoza (2DG) sta presnovni učinkovini z različnimi obetavnimi protirakavimi in imunomodulatornimi učinki. Njuna kombinacija povzroči odlepljanje živih celic raka dojke MDA-MB-231 z ohranjeno sposobnostjo proliferacije in vitro. Od podlage neodvi...
Li, Yan Li, Cuiyu Xiong, Yuhua Fang, Bin Lin, Xing Huang, Quanfang
Published in
Drug Design, Development and Therapy
Introduction Origanum vulgare L. is a traditional Chinese herb, having a strong hepatoprotective effect. In our previous experiments, we have isolated an ingredient from this herb and identified it as didymin. This study aimed to investigate the effects and underlying mechanisms of didymin on liver injury and fibrosis, elucidating whether it was th...
Fei, Fei Zheng, Meihong Xu, Zhenzhen Sun, Runbin Chen, Xin Cao, Bei Li, Juan
Published in
Frontiers in Oncology
Background Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin’s lymphoma with considerable heterogeneity and different clinical prognosis. However, plasma metabomics used to forecast occurrence and prognosis of DLBCL are rarely addressed. Method A total of 65 volunteers including 22 healthy controls (Ctrl), 25 DLBCL patients newly...
zhou;, mu yu jinna
The authors of this paper conducted a comparative metabolomic analysis of Ophiocordyceps sinensis (OS), providing the metabolic profiles of the stroma (OSBSz) and sclerotia (OSBSh) of OS by widely targeted metabolomics and untargeted metabolomics. The results showed that 778 and 1449 metabolites were identified by the widely targeted metabolomics a...
Tu, Pengcheng Chi, Liang Bian, Xiaoming Gao, Bei Ru, Hongyu Lu, Kun
Published in
Frontiers in Nutrition
Dietary modulation of the gut microbiota recently received considerable attention, and ligand activation of aryl hydrocarbon receptor (AHR) plays a pivotal role in intestinal immunity. Importantly, black raspberry (BRB, Rubus occidentalis) is associated with a variety of beneficial health effects. We aim to investigate effects of a BRB-rich diet on...
Fang, Xinyi Wu, Haoran Wang, Xinmiao Lian, Fengmei Li, Min Miao, Runyu Wei, Jiahua Tian, Jiaxing
Published in
Frontiers in Pharmacology
Introduction: Glucose and lipid metabolism disturbances has become the third major disease after cancer and cardio-cerebrovascular diseases. Emerging evidence shows that berberine can effectively intervene glucose and lipid metabolism disturbances, but the underlying mechanisms of this remain unclear. To investigate this issue, we performed metagen...
Liang, Yan Feng, Qiaoqiao Wang, Zhang
Published in
Frontiers in Pharmacology
Mass spectrometry imaging (MSI) can describe the spatial distribution of molecules in various complex biological samples, such as metabolites, lipids, peptides and proteins in a comprehensive way, and can provide highly relevant supplementary information when combined with other molecular imaging techniques and chromatography techniques, so it has ...
