Relaix, F. Bencze, M. Borok, M. J. Der Vartanian, A. Gattazzo, F. Mademtzoglou, D. Perez-Diaz, S. Prola, A. Reyes-Fernandez, P. C. Rotini, A.
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Published in
Nature Communications
Skeletal muscle has a remarkable regenerative capacity, which can largely be attributed to resident muscle stem cells (MuSCs). Here, the authors review the molecular mechanisms regulating MuSC quiescence, activation and proliferation, how these processes are regulated by the stem cell niche, and the role of MuSCs in neuromuscular diseases.
Xu, Haibo Zhao, Lina Feng, Xu Ma, Yujie Chen, Wei Zou, Li Yang, Qin Sun, Jihong Yu, Hong Jiao, Baowei
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Published in
Journal of molecular cell biology
Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic ...
Xu, Weiling Janocha, Allison J. Erzurum, Serpil C.
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are increasingly recognized as universal hallmarks of PAH, as metabolic abnormalities are identified in lungs and hearts of patients, animal models of the disease, and cells derived...
Breit, Samuel N. Brown, David A. Tsai, Vicky Wang-Wei
GDF15 is a cell activation and stress response cytokine of the glial cell line–derived neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified orphan member of the GFRα family called GFRAL and signals through the Ret coreceptor. Cell stress and disease lead to elevated GDF15 serum levels, causing anorexia, wei...
Maliszewska, Katarzyna Kretowski, Adam
Published in
International journal of molecular sciences
The increased worldwide prevalence of obesity, insulin resistance, and their related metabolic complications have prompted the scientific world to search for new possibilities to combat obesity. Brown adipose tissue (BAT), due to its unique protein uncoupling protein 1 (UPC1) in the inner membrane of the mitochondria, has been acknowledged as a pro...
Gonçalves, Renata de Castro Freire, Paula Paccielli Coletti, Dario Seelaender, Marilia
Published in
Frontiers in Oncology
Cachexia is a syndrome that affects the entire organism and presents a variable plethora of symptoms in patients, always associated with continuous and involuntary degradation of skeletal muscle mass and function loss. In cancer, this syndrome occurs in 50% of all patients, while prevalence increases to 80% as the disease worsens, reducing quality ...
Cuyàs, Elisabet Verdura, Sara Martin-Castillo, Begoña Menendez, Javier A.
Published in
Frontiers in Oncology
Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic biguanide metformin. Here, we briefly review how metabolite-derived chromatin modifications and the meta...
Shmulevich, Riva Krizhanovsky, Valery
Published in
Antioxidants & redox signaling
Significance: Senescence is an essential biological process that blocks tumorigenesis, limits tissue damage, and aids embryonic development. However, once senescent cells accumulate in tissues during aging, they promote the development of age-related diseases and limit health span. Thus, it is essential to expand the boundaries of our knowledge abo...
Zhang, Qiong Li, Xin Yin, Xiaofeng Wang, Haifang Fu, Chen Wang, Hongxia Li, Kaifei Li, Yao Zhang, Xiaohe Liang, Huijun
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Published in
Rheumatology (Oxford, England)
The spectrum of clinical manifestations and serological phenomena of SLE is heterogeneous among patients and even changes over time unpredictably in individual patients. For this reason, clinical diagnosis especially in complicated or atypical cases is often difficult or delayed leading to poor prognosis. Despite the medical progress nowadays in th...
Chen, Chongxiao White, Dima Lynn Marshall, Brett Kim, Woo Kyun
Published in
Frontiers in Physiology
A study was conducted to understand the effects of 25-hydroxyvitamin D3 (25OHD) and 1,25-dihydroxyvitamin D3 (1,25OHD) administration on the expression of key genes related to osteogenesis, adipogenesis, myogenesis, and vitamin D3 metabolism in the chicken embryo. A total of 120 fertilized Cobb 500 eggs were used in the current study and were reare...