Shaul, David Azar, Assad Sapir, Gal Uppala, Sivaranjan Nardi-Schreiber, Atara Gamliel, Ayelet Sosna, Jacob Gomori, J Moshe Katz-Brull, Rachel
Published in
NMR in biomedicine
Cardiovascular diseases account for more than 30% of all deaths worldwide and many could be ameliorated with early diagnosis. Current cardiac imaging modalities can assess blood flow, heart anatomy and mechanical function. However, for early diagnosis and improved treatment, further functional biomarkers are needed. One such functional biomarker co...
Tang, Shuyu Bok, Robert Qin, Hecong Reed, Galen VanCriekinge, Mark Delos Santos, Romelyn Overall, William Santos, Juan Gordon, Jeremy Wang, Zhen Jane
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PURPOSE:The balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized 13C magnetization, but suffers from poor spectral selectivity and long acquisition time. The purpose of this study was to develop a novel metabolite-specific 3D bSSFP ("MS-3DSSFP") sequence with stack...
Tang, Shuyu Milshteyn, Eugene Reed, Galen Gordon, Jeremy Bok, Robert Zhu, Xucheng Zhu, Zihan Vigneron, Daniel B. Larson, Peder E. Z.
Purpose: Acquisition timing and B$_1$ calibration are two key factors that affect the quality and accuracy of hyperpolarized $^{13}$C MRI. The goal of this project was to develop a new approach using regional bolus tracking to trigger Bloch-Siegert B$_1$ mapping and real-time B$_1$ calibration based on regional B$_1$ measurements, followed by dynam...
Harlan, Collin J Xu, Zhan Michel, Keith A Walker, Christopher M Lokugama, Sanjaya D Martinez, Gary V Pagel, Mark D Bankson, James A
Published in
Medical physics
Metabolic magnetic resonance imaging (MRI) using hyperpolarized [1-13 C]-pyruvate offers unprecedented new insight into disease and response to therapy. 13 C-enriched reference standards are required to enable fast and accurate calibration for 13 C studies, but care must be taken to ensure that the reference is compatible with both 13 C and 1 H acq...
Dutta, Prasanta Castro Pando, Susana Mascaro, Marilina Riquelme, Erick Zoltan, Michelle Zacharias, Niki M. Gammon, Seth T. Piwnica-Worms, David Pagel, Mark D. Sen, Subrata
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Published in
International Journal of Molecular Sciences
While pancreatic cancer (PC) survival rates have recently shown modest improvement, the disease remains largely incurable. Early detection of pancreatic cancer may result in improved outcomes and therefore, methods for early detection of cancer, even premalignant lesions, may provide more favorable outcomes. Pancreatic intraepithelial neoplasias (P...
Pouli, Dimitra Thieu, Hong-Thao Genega, Elizabeth M. Baecher-Lind, Laura House, Michael Bond, Brian Roncari, Danielle M. Evans, Megan L. Rius-Diaz, Francisca Munger, Karl
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Published in
Cell Reports Medicine
Reprogramming of cellular metabolism is an emerging cancer hallmark. Pouli et al. show that metabolic dysfunction can be detected in live human cervical biopsies using high-resolution autofluorescence images of the metabolic coenzymes NAD(P)H and FAD. The authors use morphological and functional metrics to successfully distinguish healthy tissues f...
Le Page, Lydia M Guglielmetti, Caroline Taglang, Celine Chaumeil, Myriam M
Published in
Trends in neurosciences
Aberrant metabolism is a key factor in many neurological disorders. The ability to measure such metabolic impairment could lead to improved detection of disease progression, and development and monitoring of new therapeutic approaches. Hyperpolarized 13C magnetic resonance spectroscopy (MRS) is a developing imaging technique that enables non-invasi...
Crane, Jason C Gordon, Jeremy W Chen, Hsin-Yu Autry, Adam W Li, Yan Olson, Marram P Kurhanewicz, John Vigneron, Daniel B Larson, Peder E Z Xu, Duan
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Published in
NMR in biomedicine
Based on the expanding set of applications for hyperpolarized carbon-13 (HP-13 C) MRI, this work aims to communicate standardized methodology implemented at the University of California, San Francisco, as a primer for conducting reproducible metabolic imaging studies of the prostate and brain. Current state-of-the-art HP-13 C acquisition, data proc...
Clifford, Bryan Gu, Yuning Liu, Yuchi Kim, Kihwan Huang, Sherry Li, Yudu Lam, Fan Liang, Zhi-Pei Yu, Xin
Published in
IEEE transactions on bio-medical engineering
Objective: To enable non-invasive dynamic metabolic mapping in rodent model studies of mitochondrial function using 31P-MR spectroscopic imaging (MRSI). Methods: We developed a novel method for high-resolution dynamic 31P-MRSI. The method synergistically integrates physics-based models of spectral structures, biochemical modeling of molecular dynam...
Gallagher, Ferdia A Woitek, Ramona McLean, Mary A Gill, Andrew B Manzano Garcia, Raquel Provenzano, Elena Riemer, Frank Kaggie, Joshua Chhabra, Anita Ursprung, Stephan
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenous tumor lactate pool. Treatment-naïve breast cancer patients were recruited: four triple-negative grade 3...
