He, Saifei Ma, Xiaokun Zheng, Ni Wang, Guoyu Wang, Menghan Xia, Wei Yu, Donghai
Published in
Molecular medicine reports
Recent studies have reported that aberrant PR domain zinc finger protein 14 (PRDM14) expression is associated with the therapeutic sensitivity of cancer cells to drugs. However, its role in lung adenocarcinoma (LUAD) remains unclear. The present study aimed to determine the functions of knockdown or overexpression of PRDM14 in the chemosensitivity ...
Glenstrup, Stine Bast, Lotus Sofie Danielsen, Dina Andersen, Anette Tjørnhøj-Thomsen, Tine
Published in
International journal of environmental research and public health
Several established school smoking prevention initiatives involve restrictions on places to smoke. The focus on tobacco control in schools is due to the risk of smoking initiation during adolescence and the perception of this life stage as a period of time when health behavior is established. Hence, this period of time is considered to be ideal for...
Cenci, Alberto Sardos, Julie Hueber, Yann Martin, Guillaume Breton, Catherine Roux, Nicolas Swennen, Rony Carpentier, Sebastien Christian Rouard, Mathieu
Published in
Annals of botany
Bananas (Musa spp.) are a major staple food for hundreds of millions of people in developing countries. The cultivated varieties are seedless and parthenocarpic clones of which the ancestral origin remains to be clarified. The most important cultivars are triploids with an AAA, AAB or ABB genome constitution, with A and B genomes provided by M. acu...
Bel Borja, Laura Soubigou, Flavie Taylor, Samuel J P Fraguas Bringas, Conchita Budrewicz, Jacqueline Lara-Gonzalez, Pablo Sorensen Turpin, Christopher G Bembenek, Joshua N Cheerambathur, Dhanya K Pelisch, Federico
...
Published in
eLife
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore-microtubule attachments in yeast and mouse meiosis. In Caenorhabditis elegans, the closest BUBR1 ortho...
Krausz, Csilla Riera-Escamilla, Antoni Moreno-Mendoza, Daniel Holleman, Kaylee Cioppi, Francesca Algaba, Ferran Pybus, Marc Friedrich, Corinna Wyrwoll, Margot J Casamonti, Elena
...
Published in
Genetics in medicine : official journal of the American College of Medical Genetics
Azoospermia affects 1% of men and it can be the consequence of spermatogenic maturation arrest (MA). Although the etiology of MA is likely to be of genetic origin, only 13 genes have been reported as recurrent potential causes of MA. Exome sequencing in 147 selected MA patients (discovery cohort and two validation cohorts). We found strong evidence...
Koch, Bailey A Staley, Elizabeth Jin, Hui Yu, Hong-Guo
Published in
Nucleus (Austin, Tex.)
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal. The mechanism that regulates cellular rejuvenation remains to be further elucidated. Using budding yeast gametogenesis as a model, we show here that the endosomal sorting compl...
Sanchez, Aurore Adam, Céline Rauh, Felix Duroc, Yann Ranjha, Lepakshi Lombard, Bérangère Mu, Xiaojing Wintrebert, Mélody Loew, Damarys Guarné, Alba
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Crossovers generated during the repair of programmed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregation without deleterious outcomes, such as aneuploidy. The Mlh1-Mlh3 (MutLγ) endonuclease complex is critical for crossover resolution, which involves mechanistically unclear interplay between MutLγ and Exo1...
Oliveira, Sara I de Ribeiro, Elba H Moreira, Nádia F Vianna, Larissa S Pereira, Telma NS
ABSTRACT This study was performed to evaluate the meiotic behavior and fertility of four hybrids obtained from the crossing of Capsicum baccatum and its botanical forms with Capsicum chinense and Capsicum frutescens. We aimed to identify the causes of the low fertility in interspecific hybrids involving species from different gene pools of Capsicum...
Calvo-Baltanás, Vanesa Wijnen, Cris L Yang, Chao Lukhovitskaya, Nina de Snoo, C Bastiaan Hohenwarter, Linus Keurentjes, Joost J B de Jong, Hans Schnittger, Arp Wijnker, Erik
...
Published in
The Plant journal : for cell and molecular biology
Plant breeding applications exploiting meiotic mutant phenotypes (like the increase or decrease of crossover (CO) recombination) have been proposed over the last years. As recessive meiotic mutations in breeding lines may affect fertility or have other pleiotropic effects, transient silencing techniques may be preferred. Reverse breeding is a breed...
Fang, Kailun Li, Qidan Wei, Yu Zhou, Changyang Guo, Wenhui Shen, Jiaqi Wu, Ruoxi Ying, Wenqin Yu, Lu Zi, Jin
...
Published in
Molecular & cellular proteomics : MCP
The molecular mechanism associated with mammalian meiosis has yet to be fully explored, and one of the main reasons for this lack of exploration is that some meiosis-essential genes are still unknown. The profiling of gene expression during spermatogenesis has been performed in previous studies, yet few studies have aimed to find new functional gen...
