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Combined analytical study on chemical transformations and detoxification of model phenolic pollutants during various adv...

Advanced oxidation processes (AOPs) have been introduced to deal with different types of water pollution. They cause effective chemical destruction of pollutants, yet leading to a mixture of transformation by-products, rather than complete mineralization. Therefore, the aim of our study was to understand complex degradation processes induced by dif...

Razvoj LC-MS metode za določitev askorbinske in eritorbinske kisline

Razvili smo metodo tekočinske kromatografije visoke ločljivosti sklopljene s tandemsko masno spektrometrijo za določitev askorbinske kisline in njenega izomera, eritorbinske kisline. Za separacijo smo uporabili Aminex HPX-87H kolono in izokratsko elucijo z 0,1 % mravljično kislino v vodi. Kvantifikacijo smo izvedli z uporabo ESI ionizacije v negati...

Aedes aegypti Aag-2 Cell Proteome Modulation in Response to Chikungunya Virus Infection

Published in Frontiers in Cellular and Infection Microbiology

Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes albopictus bites. In humans, CHIKV usually causes painful symptoms during acute and chronic stages of infection. Conversely, virus–vector interaction does not disturb the mosquito’s ...

Quantum Chemistry‐based Molecular Dynamics Simulations as a Tool for the Assignment of ESI‐MS/MS Spectra of Drug Molecul...

In organic mass spectrometry, fragment ions provide important information on the analyte as a central part of its structure elucidation. With increasing molecular size and possible protonation sites, the potential energy surface (PES) of the analyte can become very complex, which results in a large number of possible fragmentation patterns. Quantum...

Alterations of RNA Modification in Mouse Germ Cell-2 Spermatids Under Hypoxic Stress

Published in Frontiers in Molecular Biosciences

Hypoxia is a known stress factor in mammals and has been shown to potentially impair male fertility, which manifests as spermatogenic dysfunction and decreased semen quality. Studies have shown that RNA modifications, the novel post-transcriptional regulators, are involved in spermatogenesis, and hypoxia-induced alterations in RNA modification in t...

Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation

Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are differentially regulated in a multitude of neurological, metabolic, and mental disorders. Mass spectrometry (MS) has ev...

Analytical Chemistry Throughout This Solar System

One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in situ measurements, is inherently constrained by the analytical (often chemical) techniques we employ in these end...