Xie, Hui Hua, Zhengying Guo, Mengyu Lin, Shangyang Zhou, Yaqian Weng, Zebin Wu, Li Chen, Zhipeng Xu, Zisheng Li, Weidong
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Published in
Pharmaceutical biology
The traditional Chinese medicine Qing'e Pills (QEP) has been used to treat postmenopausal osteoporosis (PMO). We evaluated the regulatory effects of QEP on gut microbiota in osteoporosis. Eighteen female SD rats were divided into three groups: sham surgery (SHAM), ovariectomized (OVX) and ovariectomized treated with QEP (OVX + QEP). Six weeks after...
Albertini, Simon Gruber, Elisabeth Zappa, Fabio Krasnokutski, Serge Laimer, Felix Scheier, Paul
Published in
Mass spectrometry reviews
Helium droplets represent a cold inert matrix, free of walls with outstanding properties to grow complexes and clusters at conditions that are perfect to simulate cold and dense regions of the interstellar medium. At sub-Kelvin temperatures, barrierless reactions triggered by radicals or ions have been observed and studied by optical spectroscopy a...
Kravos, Aleksander Žgajnar Gotvajn, Andreja Lavrenčič Štangar, Urška Malinović, Borislav N. Prosen, Helena
Advanced oxidation processes (AOPs) have been introduced to deal with different types of water pollution. They cause effective chemical destruction of pollutants, yet leading to a mixture of transformation by-products, rather than complete mineralization. Therefore, the aim of our study was to understand complex degradation processes induced by dif...
Nikolić, Mina
Razvili smo metodo tekočinske kromatografije visoke ločljivosti sklopljene s tandemsko masno spektrometrijo za določitev askorbinske kisline in njenega izomera, eritorbinske kisline. Za separacijo smo uporabili Aminex HPX-87H kolono in izokratsko elucijo z 0,1 % mravljično kislino v vodi. Kvantifikacijo smo izvedli z uporabo ESI ionizacije v negati...
Vasconcellos, Anna Fernanda Melo, Reynaldo Magalhães Mandacaru, Samuel Coelho de Oliveira, Lucas Silva de Oliveira, Athos Silva Moraes, Emily Caroline dos Santos Trugilho, Monique Ramos de Oliveira Ricart, Carlos André Ornelas Báo, Sônia Nair Resende, Renato Oliveira
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Published in
Frontiers in Cellular and Infection Microbiology
Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes albopictus bites. In humans, CHIKV usually causes painful symptoms during acute and chronic stages of infection. Conversely, virus–vector interaction does not disturb the mosquito’s ...
Schnegotzki, Romina Koopman, Jeroen Grimme, Stefan Süssmuth, Roderich D.
In organic mass spectrometry, fragment ions provide important information on the analyte as a central part of its structure elucidation. With increasing molecular size and possible protonation sites, the potential energy surface (PES) of the analyte can become very complex, which results in a large number of possible fragmentation patterns. Quantum...
He, Tong Guo, Huanping Xia, Lin Shen, Xipeng Huang, Yun Wu, Xiao Jiang, Xuelin Xu, Yinying Tan, Yi Zhang, Yunfang
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Published in
Frontiers in Molecular Biosciences
Hypoxia is a known stress factor in mammals and has been shown to potentially impair male fertility, which manifests as spermatogenic dysfunction and decreased semen quality. Studies have shown that RNA modifications, the novel post-transcriptional regulators, are involved in spermatogenesis, and hypoxia-induced alterations in RNA modification in t...
De La Toba, Eduardo A. Bell, Sara E. Romanova, Elena V. Sweedler, Jonathan V.
Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are differentially regulated in a multitude of neurological, metabolic, and mental disorders. Mass spectrometry (MS) has ev...
Seaton, Kenneth Marshall Cable, Morgan Leigh Stockton, Amanda Michelle
One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in situ measurements, is inherently constrained by the analytical (often chemical) techniques we employ in these end...
Skaggs, Christine Zimmerman, Hannah Manicke, Nicholas Kirkpatrick, Lindsey
Published in
Journal of Mass Spectrometry and Advances in the Clinical Lab
Introduction Remdesivir (GS-5734) is a nucleoside analog prodrug with antiviral activity against several single-stranded RNA viruses, including the novel severe respiratory distress syndrome virus 2 (SARS-CoV-2). It is currently the only FDA-approved antiviral agent for the treatment of individuals with COVID-19 caused by SARS-CoV-2. However, remde...