A policy model of cardiovascular disease in moderate-to-advanced chronic kidney disease.
...Published in Heart (British Cardiac Society)
NCT00125593 and ISRCTN54137607; Post-results.
Clinical and economic benefits of extended treatment with apixaban for the treatment and prevention of recurrent venous ...
Published in Journal of medical economics
Background and objective Venous thromboembolism (VTE) is associated with long-term clinical and economic burden. Clinical guidelines generally recommend at least 3 months of anticoagulation, but, in clinical practice, concerns over bleeding risk often limit extended treatment. Apixaban was studied for extended VTE treatment in the AMPLIFY-EXT trial...
Clinical and economic benefits of extended treatment with apixaban for the treatment and prevention of recurrent venous ...
Published in Journal of medical economics
Background and objective Venous thromboembolism (VTE) is associated with long-term clinical and economic burden. Clinical guidelines generally recommend at least 3 months of anticoagulation, but, in clinical practice, concerns over bleeding risk often limit extended treatment. Apixaban was studied for extended VTE treatment in the AMPLIFY-EXT trial...
Mixed Treatment Comparison and Bayesian Integrated Economic Evaluation of Cost-Effectiveness and Budget Impact of TNF-al...
Contexte : 80% des patients souffrant de polyarthrite rhumatoïde ne répondent pas aux traitements à base de méthotrexate et font l’objet d’une prise en charge par anti TNF-α.Objectifs : Cette étude se propose d’évaluer l’efficacité et l’innocuité des biothérapies utilisées en seconde ligne de traitement sur les patients atteints de polyarthrite rhu...
Mixed Treatment Comparison and Bayesian Integrated Economic Evaluation of Cost-Effectiveness and Budget Impact of TNF-al...
Contexte : 80% des patients souffrant de polyarthrite rhumatoïde ne répondent pas aux traitements à base de méthotrexate et font l’objet d’une prise en charge par anti TNF-α.Objectifs : Cette étude se propose d’évaluer l’efficacité et l’innocuité des biothérapies utilisées en seconde ligne de traitement sur les patients atteints de polyarthrite rhu...
Cost-effectiveness analysis of axitinib through a probabilistic decision model.
Published in Expert opinion on pharmacotherapy
Compared to sorafenib, axitinib resulted in an incremental cost of 87,936 euro per quality adjusted life year. The probability of axitinib to being cost-effective at the willingness-to-pay threshold of 60,000 euro was 13%, while the corresponding probability of being cost-effective at the highest recommended willingness-to-pay threshold of 100,000 ...
A Markov model of land use dynamics
The application of the Markov chain to modeling agricultural succession is well known. In most cases, the main problem is the inference of the model, i.e. the estimation of the transition matrix. In this work we present methods to estimate the transition matrix from historical observations. In addition to the estimator of maximum likelihood (MLE), ...
A Markov model of land use dynamics
The application of the Markov chain to modeling agricultural succession is well known. In most cases, the main problem is the inference of the model, i.e. the estimation of the transition matrix. In this work we present methods to estimate the transition matrix from historical observations. In addition to the estimator of maximum likelihood (MLE), ...
A Markov model of land use dynamics
The application of the Markov chain to modeling agricultural succession is well known. In most cases, the main problem is the inference of the model, i.e. the estimation of the transition matrix. In this work we present methods to estimate the transition matrix from historical observations. In addition to the estimator of maximum likelihood (MLE), ...
A gating model for wildtype and R1448H Nav1.4 channels in paramyotonia.
We studied the consequences of the Nav1.4 mutation R1448H that is situated in the fourth voltage sensor of the channel and causes paramyotonia, a cold-induced myotonia followed by weakness. Previous work showed that the mutation uncouples inactivation from activation. We measured whole-cell Na(+) currents at 10, 15, 20, and 25°C using HEK293 cells ...
