INTRODUCTION: Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate targeting delta-like protein 3 (DLL3), an atypical Notch ligand expressed in small cell lung cancer (SCLC) tumors. We evaluated the efficacy of Rova-T versus placebo as maintenance therapy in patients with extensive stage (ES) SCLC after platinum-based chemotherapy. METHOD...
In the nervous system, billions of neurons undergo a multistep process to establish functional circuits. This entails accurate extension of dendritic and axonal processes and coordinated efforts of pre- and postsynaptic neurons to form synaptic connections. Although many axon guidance molecules and synaptic organizers have been identified, the mole...
Objectives: The use of digital health technologies (DHT) is increasingly ubiquitous in intervention studies aimed at reducing health risks or improving the management of chronic diseases such as cancer. However, although DHT clearly show promises for a variety of applications, one third of users quit using DHT less than six months after the purchas...
Povečano notranje puščanje hidravličnega sistema je eden izmed znakov okvare oziroma poškodbe hidravličnega sistema traktorja. Obrabi in staranju elementov v hidravličnem sistemu se ne moremo izogniti, lahko pa z ustreznim vzdrževanjem in pravilnim rokovanjem, bistveno vplivamo na dolžino uporabne dobe sistema. Namen zaključne naloge je predstaviti...
Published in The International journal of eating disorders
Low positive affect has been identified as an antecedent of binge-eating episodes among individuals with binge-eating disorder (BED), yet positive affect has received far less attention in eating disorders research than its counterpart, negative affect. In this article, we argue that the low levels of positive affect which occur with anhedonia (i.e...
Free and/or open-source software (or F/OSS) projects now play a major and dominant role in society, constituting critical digital infrastructure relied upon by companies, academics, non-profits, activists, and more. As F/OSS has become larger and more established, we investigate the labor of maintaining and sustaining those projects at various scal...
Published in Journal of Blood Medicine
Relapse rates following allogeneic stem cell transplantation for acute myeloid leukemia remain unacceptably high and a major cause of death. Maintenance therapies post-transplant administered either to patients with impending relapse or at high risk of relapse could present a strategy to improve survival and overall outcomes. With the increasing us...
Published in Journal of Clinical Medicine
(1) Background: Adherence to and the maintenance of treatment regimens are fundamental for pain self-management and sustainable behavioural changes. The first aim was to study older adults’ (>65 years) levels of adherence to and maintenance of musculoskeletal pain self-management programmes in randomized controlled trials. The second aim was to sug...
Published in Materials
The technical maintenance of old tenement houses traditionally constructed is an ongoing problem, and will continue to be so in the coming years. The subject of the article includes old residential buildings from the turn of the XIX and XX centuries, which are a part of Wroclaw’s downtown district. They can be understood as an essential link in the...
Published in International Journal of Environmental Research and Public Health
Living with obesity is related to numerous negative health outcomes, including various cancers, type II diabetes, and cardiovascular disease. Although much is known about the factors associated with obesity, and a range of weight loss interventions have been established, changing health-related behaviours to positively affect obesity outcomes has p...
