Mahboub, Paria Aburawi, Mohamed Ozgur, O. Sila Pendexter, Casie Cronin, Stephanie Lin, Florence Min Jain, Rohil Karabacak, Murat N. Karimian, Negin Tessier, Shannon N.
...
Published in
Frontiers in Transplantation
Background Donation after circulatory death (DCD) grafts are vital for increasing available donor organs. Gradual rewarming during machine perfusion has proven effective in mitigating reperfusion injury and enhancing graft quality. Limited data exist on artificial oxygen carriers as an effective solution to meet the increasing metabolic demand with...
De Simone, Paolo Ghinolfi, Davide Palladino, Simona Catalano, Gabriele Martinelli, Caterina Ducci, Juri Bronzoni, Jessica Tincani, Giovanni Balzano, Emanuele Carrai, Paola
...
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with ...
Husain, Irma Luo, Xunrong
Despite significant advances in the field of transplantation in the past two decades, current clinically available therapeutic options for immunomodulation remain fairly limited. The advent of calcineurin inhibitor–based immunosuppression has led to significant success in improving short-term graft survival; however, improvements in long-term graft...
Lucia, Angelo Uygun, Korkut
Published in
Frontiers in Systems Biology
The current clinical standard of Static Cold Storage (SCS) which involves preservation on ice (about +4°C) in a hypoxic state limits storage to a few hours for metabolically active tissues such as the liver and the heart. This period of hypoxia during can generate superoxide and other free radicals from purine metabolism, a well-established compone...
Watson, Christopher JE Gaurav, Rohit Butler, Andrew J
Since the advent of University of Wisconsin preservation solution in the 1980s, clinicians have learned to work within its confines. While affording improved outcomes, considerable limitations still exist and contribute to the large number of livers that go unused each year, often for fear they may never work. The last 10 years have seen the widesp...
Goutard, Marion Tawa, Pierre Berkane, Yanis Andrews, Alec R. Pendexter, Casie A. de Vries, Reinier J. Pozzo, Victor Romano, Golda Lancia, Hyshem H. Filz von Reiterdank, Irina
...
The current gold standard for preserving vascularized composite allografts (VCA) is 4 degrees C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP) is growing in the world of organ preservation. Herein, we investigated the outcomes of oxygenated acel...
Norén, Åsa Mölne, Johan Bennet, William Sörensen, Gustaf Herlenius, Gustaf Lindnér, Per Oltean, Mihai
Published in
Artificial organs
Organ transplantation using grafts from elderly donors entails a higher risk for severe ischemia-reperfusion injury (IRI). Advanced IRI after liver transplantation (LT) seems to be associated with the development of acute kidney injury (AKI). We studied if end-ischemic hypothermic oxygenated machine perfusion (HOPE) of liver grafts, aimed at mitiga...
Gilbo, Nicholas; 93882; Blondeel, Joris; 134230; Pirenne, Jacques; 2174; Romagnoli, Renato; Camussi, Giovanni; Monbaliu, Diethard; 27938;
Organ preservation and assessment with machine perfusion (MP) has provided transplant physicians with the ability to evaluate and select grafts suitable for transplantation. Nevertheless, the discard of organs considered too damaged still sustains the imbalance between donor organs supply and demands. Therefore, there is the pressing clinical need ...
Berkane, Yanis Hayau, Justine Filz von Reiterdank, Irina Kharga, Anil Charlès, Laura Mink van der Molen, Abele B. Coert, J. Henk Bertheuil, Nicolas Randolph, Mark A. Cetrulo, Curtis L. Jr.
...
Published in
Frontiers in Transplantation
Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or s...
Iske, Jasper Schroeter, Andreas Knoedler, Samuel Nazari-Shafti, Timo Z. Wert, Leonard Roesel, Maximilian J. Hennig, Felix Niehaus, Adelheid Kuehn, Christian Ius, Fabio
...
Published in
Frontiers in Cardiovascular Medicine
Ex vivo machine perfusion (EVMP) is an emerging technique for preserving explanted solid organs with primary application in allogeneic organ transplantation. EVMP has been established as an alternative to the standard of care static-cold preservation, allowing for prolonged preservation and real-time monitoring of organ quality while reducing/preve...
