Berkane, Yanis Hayau, Justine Filz von Reiterdank, Irina Kharga, Anil Charlès, Laura Mink van der Molen, Abele B. Coert, J. Henk Bertheuil, Nicolas Randolph, Mark A. Cetrulo, Curtis L. Jr.
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Published in
Frontiers in Transplantation
Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or s...
Iske, Jasper Schroeter, Andreas Knoedler, Samuel Nazari-Shafti, Timo Z. Wert, Leonard Roesel, Maximilian J. Hennig, Felix Niehaus, Adelheid Kuehn, Christian Ius, Fabio
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Published in
Frontiers in Cardiovascular Medicine
Ex vivo machine perfusion (EVMP) is an emerging technique for preserving explanted solid organs with primary application in allogeneic organ transplantation. EVMP has been established as an alternative to the standard of care static-cold preservation, allowing for prolonged preservation and real-time monitoring of organ quality while reducing/preve...
Kim, Joohyun Hong, Seung-Keun Yang, Yongqiang Lee, Alice Hoffmeister, Karin M. Gantner, Benjamin N. Park, Jong-In
Published in
Frontiers in Transplantation
Introduction Machine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better understanding of the molecular mechanisms underlying the ischemia-reperfusion injury (IRI) during ex vivo perfusion is necessary to improve the viability of liver grafts after transplanta...
Kahan, Riley Cray, Paul L. Abraham, Nader Gao, Qimeng Hartwig, Matthew G. Pollara, Justin J. Barbas, Andrew S.
Published in
Frontiers in Medicine
Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-mediated production of reactive oxygen and nitrogen species that are a major cause of uncontrol...
Whitson, Bryan A. Black, Sylvester M.
Published in
Frontiers in Transplantation
Kunkel, Gregory Sorokin, Igor Oster, Michela Van Horn, Christine Movahedi, Babak Pang-Yen, Fan Martins, Paulo N
Published in
Artificial organs
The incidence of nephrolithiasis in kidney donors is rare. The timing and treatment of nephrolithiasis in deceased donor kidneys are not well established. While some programs have proposed ex-situ rigid or flexible ureteroscopy treatment before transplantation, we report on two cases of kidney stones in the same deceased donor that we treated by fl...
Ozgur, Ozge Sila Namsrai, Bat-Erdene Pruett, Timothy L. Bischof, John C. Toner, Mehmet Finger, Erik B. Uygun, Korkut
Published in
Frontiers in Transplantation
Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion. They also bring the promise of extending the preservation duration significantly, which opens the ...
Vargas, Paola A. Yu, Christine Goldaracena, Nicolas
Published in
Frontiers in Transplantation
Introduction Following procurement, the liver graft is exposed to an ischemic period that triggers several pathophysiologic changes in response to oxygen deprivation. Therefore, the goal during organ preservation is to attenuate such response and provide an adequate environment that prepares the graft for its metabolic reactivation following implan...
Eden, Janina Da Silva, Richard Sousa Cortes-Cerisuelo, Miriam Croome, Kristopher De Carlis, Riccardo Hessheimer, Amelia J Muller, Xavier de Goeij, Femke Banz, Vanessa Magini, Giulia
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peer reviewed / [en] BACKGROUND AND AIM: Liver graft utilization rates are a hot topic due to the worldwide organ shortage and an increasing number of transplant candidates on waiting lists. Liver perfusion techniques have been introduced in several countries, and may help to increase the organ supply, as they potentially allow the assessment of li...
Eden, Janina Sousa Da Silva, Richard Cortes-Cerisuelo, Miriam Croome, Kristopher De Carlis, Riccardo Hessheimer, Amelia J Muller, Xavier de Goeij, Femke Banz, Vanessa Magini, Giulia
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Published in
Journal of hepatology
Liver graft utilization rates are a hot topic due to the worldwide organ shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion techniques have been introduced in several countries, and may help to increase the organ supply, as they potentially enable the assessment of livers before use. Liver offers were coun...
