Tsang, Chi Kwan Mi, Qiongjie Su, Guangpu Hwa Lee, Gum Xie, Xuemin D'Arcangelo, Gabriella Huang, Li'an Steven Zheng, X F
Published in
Journal of advanced research
Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 is known as a key growth suppressor in proliferating cells. However, its role in neuronal cells after stroke remains unclear. We aimed to investigate the mechanistic role of Maf1 in spontaneous neural repair and e...
Nguyen, Lena H. Sharma, Manas Bordey, Angelique
Published in
Frontiers in Neuroscience
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway during neurodevelopment leads to focal cortical malformations associated with intractable seizures. Recent evidence suggests that dysregulated cap-dependent translation downstream of mTORC1 contributes to cytoarchitectural abnormalities and seizure activity. Here, we ...
Lee, Jong Yeong Lee, Ji-Hyun Lim, Hyo Jung Kim, Eonho Kim, Dae-Ki Choi, Jin Kyeong
Published in
Frontiers in Pharmacology
Background: Psoriasis is a common chronic inflammatory skin disease characterized by an external red rash that is caused by abnormal proliferation and differentiation of keratinocytes and immune T cells. This study aimed to elucidate the role of aminooxy acetic acid (AOA) in alleviating psoriasis from the perspective of immunology and metabolomics....
Zhang, Xizhou Wu, Jinyao Yang, Qiuping Tian, Huiting Chen, Lingzhi Zheng, Daitian Ji, Zeqi Cai, Jiehui Chen, Yexi Li, Zhiyang
...
Published in
Frontiers in Oncology
Over the past decade, thousands of articles have been published on the mechanistic target of rapamycin (mTOR) and its role in breast cancer. However, the variability and heterogeneity of academic data may impact the acquisition of published research information. Due to the large number, heterogeneity, and varying quality of publications related to ...
Moellmann, Julia; Krueger, Katja; Wong, Dickson WL; Klinkhammer, Barbara M; Buhl, Eva M; Dehairs, Jonas; 65634; Swinnen, Johan V; 19636; Noels, Heidi; Jankowski, Joachim; Lebherz, Corinna;
...
AIM: Chronic kidney disease (CKD) is accompanied by increased cardiovascular risk and heart failure (HF). In rodents, 2,8-dihydroxyadenine (DHA)-induced nephropathy is a frequently used CKD model. Cardiac and kidney tubular cells share high energy demand to guarantee constant contractive force of the heart or reabsorption/secretion of primary filtr...
Cox, Alysia Tung, Madelynn Li, Hui Hallows, Kenneth R Chung, Eun Ji
Published in
SLAS technology
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and is characterized by the formation of renal cysts and the eventual development of end-stage kidney disease. One approach to treating ADPKD is through inhibition of the mammalian target of rapamycin (mTOR) pathway, which has been implicated in cell over...
Zhang, Huan Zhang, Can Nie, Xiaoqun Wu, Yuwei Yang, Chen Jiang, Weihong Gu, Yang
Published in
Microorganisms
Clostridium ljungdahlii is a representative autotrophic acetogen capable of producing multiple chemicals from one-carbon gases (CO2/CO). The metabolic and regulatory networks of this carbon-fixing bacterium are interesting, but still remain minimally explored. Here, based on bioinformatics analysis followed by functional screening, we identified a ...
Subramani, Murali Van Hook, Matthew J. Ahmad, Iqbal
Published in
Frontiers in Cell and Developmental Biology
The selective degeneration of retinal ganglion cells (RGCs) is a common feature in glaucoma, a complex group of diseases, leading to irreversible vision loss. Stem cell-based glaucoma disease modeling, cell replacement, and axon regeneration are viable approaches to understand mechanisms underlying glaucomatous degeneration for neuroprotection, ex ...
Xu, Jiahui Velleman, Sandra G.
Published in
Frontiers in Physiology
Wang, Ziyi Guo, Zhe Wang, Xuesong Liao, Haiyan Chen, Feng Liu, Yuxin Wang, Zhong
Published in
Frontiers in Immunology
Introduction Sepsis-induced acute lung injury (SALI) is a critical illness with high mortality, and pulmonary microvascular endothelial cells (PMECs) barrier dysfunction is a well-documented pathogenesis of SALI. The current study aimed to investigate the underlying mechanism of Reduning (RDN) in the treatment of SALI. Methods Network pharmacology ...
