Iskender, Ilker Arni, Stephan Maeyashiki, Tatsuo Citak, Necati Sauer, Mareike Rodriguez, Josep Monné Frauenfelder, Thomas Opitz, Isabelle Weder, Walter Inci, Ilhan
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Published in
The Journal of thoracic and cardiovascular surgery
Improvement in ex vivo lung perfusion protocols could increase the number of donors available for transplantation and protect the lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during ex vivo lung perfusion reconditions the allograft to ischemia-reperfusion injury after lung transplantation. Donor pig lungs were pres...
Iskender, Ilker; 136629; Arni, Stephan; Maeyashiki, Tatsuo; Citak, Necati; Sauer, Mareike; Rodriguez, Josep Monné; Frauenfelder, Thomas; Opitz, Isabelle; Weder, Walter; Inci, Ilhan;
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OBJECTIVE: Improvement in ex vivo lung perfusion protocols could increase the number of donors available for transplantation and protect the lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during ex vivo lung perfusion reconditions the allograft to ischemia-reperfusion injury after lung transplantation. METHODS: Donor...
Riddell, Peter Moshkelgosha, Sajad Levy, Liran Chang, Nina Pal, Prodipto Halloran, Kieran Halloran, Phil Parkes, Michael Singer, Lianne G Keshavjee, Shaf
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Published in
Clinical & Translational Immunology
In this case report, we describe progressive allograft dysfunction following lung transplant for interstitial lung disease due to COPA syndrome. Following the failure of standard immunosuppressive approaches, detailed cytokine analysis was performed with the intention of personalising therapy. We identified IL‐6 upregulation associated with graft i...
Swaminathan, Aparna C. Todd, Jamie L. Palmer, Scott M.
Lung transplantation improves survival and quality of life in patients with advanced pulmonary disease. Over the past several decades, the volume of lung transplants has grown substantially, with increasing transplantation of older and acutely ill individuals facilitated by improved utilization and preservation of available donor organs. Other adva...
Hunt, Jessica Chapple, Kristina M. Nasar, Aasya Cherrier, Lauren Walia, Rajat
Published in
Multidisciplinary Respiratory Medicine
Background Cytomegalovirus (CMV) infection is extremely common after lung transplant and can be associated with significant morbidity and mortality. Current practice suggests the use of 900 mg daily of valganciclovir for CMV prophylaxis, but there is no literature assessing whether 450 mg daily of valganciclovir is sufficient in intermediate CMV ri...
Kim, Ha Eun Paik, Hyo Chae Jeong, Su Jin Park, Moo Suk Kim, Song Yee Lee, Jin Gu
Published in
Yonsei Medical Journal
Purpose Calcineurin inhibitor (CNI) use has improved lung transplantation outcomes. However, significant perioperative complications in patients receiving CNI can deteriorate the early course of lung transplantation. To date, there is no consensus regarding the optimal agent for the induction regimen after lung transplantation. We aimed to determin...
Dugger, Daniel T Fung, Monica Hays, Steven R Singer, Jonathan P Kleinhenz, Mary E Leard, Lorriana E Golden, Jeffrey A Shah, Rupal J Lee, Joyce S Deiter, Fred
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Chronic lung allograft dysfunction (CLAD) is the major barrier to long-term survival following lung transplantation, and new mechanistic biomarkers are needed. Lymphocytic bronchitis (LB) precedes CLAD and has a defined molecular signature. We hypothesized that this LB molecular signature would be associated with CLAD in small airway brushings inde...
Hardman, Gillian Sutcliffe, Ruth Hogg, Rachel Mumford, Lisa Grocott, Laura Mead-Regan, Sarah-Jane Nuttall, Jane Dunn, Stephanie Seeley, Philip Clark, Stephen
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Published in
Clinical transplantation
Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, and evaluation of changes to practice is required to inform future decision-making. A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been perfor...
Masuda, Takahiro Mittal, Sumeet K Csucska, Máté Kovacs, Balazs Walia, Rajat Huang, Jasmine L Smith, Michael A Bremner, Ross M
Published in
The Journal of thoracic and cardiovascular surgery
Esophageal aperistalsis has been considered a relative contraindication for lung transplant because of a higher risk of allograft dysfunction secondary to reflux and aspiration induced by poor esophageal clearance. We previously reported that esophageal motility improves in some patients after lung transplant. We reviewed the clinical course of lun...
Gaysinskaya, Valeriya Stanley, Susan E Adam, Soheir Armanios, Mary
Published in
Chest
Idiopathic pulmonary fibrosis (IPF) is the most common of short telomere phenotypes. Familial clustering of IPF is common, but the genetic basis remains unknown in more than one-half of cases. We identified a 65-year-old man with familial IPF, short telomere length, and low telomerase RNA levels. He was diagnosed with a short telomere syndrome afte...
