Zheng, Qiaoling Zhang, Jianyong Wang, Xinchen Zhang, Wenxiong Xiao, Yipo Hu, Sheng Xu, Jianjun
Published in
OncoTargets and therapy
Purpose Increased use of low-dose spiral computed tomography (LDCT: low-dose computed tomography) screening has contributed to more frequent incidental detection of peripheral lung nodules, part of them were adenocarcinoma, which need to be further evaluated to establish a definitive diagnosis. Here, our primary objective was to evaluate the ambien...
Funston, Garth
Published in
The British Journal of General Practice
Background National guidelines in England recommend prompt chest X-ray (within 14 days) in patients presenting in general practice with unexplained symptoms of possible lung cancer, including persistent cough, shortness of breath, or weight loss. Aim To examine time to chest X-ray in symptomatic patients in English general practice before lung canc...
Koczkodaj, Paweł Didkowska, Joanna
Published in
Tobacco Induced Diseases
Hałas-Wiśniewska, Marta Izdebska, Magdalena Zielińska, Wioletta Grzanka, Alina
Published in
Cancer Management and Research
Purpose Metastasis remains a serious clinical problem in which epithelial-to-mesenchymal transition is strictly involved. The change of cell phenotype is closely related to the dynamics of the cytoskeleton. Regarding the great interest in microfilaments, the manipulation of ABPs (actin-binding proteins) appears to be an interesting treatment strate...
Wu, Mingxin Mou, Ruiyu Liu, Xiaodi Guo, Shanqi Kong, Fanming Li, Xiaojiang Jia, Yingjie
Published in
Medicine
Introduction: COVID-19 has become a common threat to global human health and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some asymptomatic patients with early-stage lung cancer who have COVID-19 receive surgical treatment but develop severe pneumonia and other complications or even experience postoperative death, and ...
Gunatilake, Samal Lodge, David Neville, Daniel Jones, Thomas Fogg, Carole Bassett, Paul Begum, Selina Kerley, Sumita Marshall, Laura Glaysher, Sharon
...
Published in
BMJ Open Respiratory Research
Introduction The prognosis of malignant pleural mesothelioma (MPM) is poor, with a median survival of 8–12 months. The ability to predict prognosis in MPM would help clinicians to make informed decisions regarding treatment and identify appropriate research opportunities for patients. The aims of this study were to examine associations between clin...
Wang, Yirong Yang, Lei Yang, Yan Li, Yulin
Published in
Cancer Management and Research
Objective To study the effect and potential mechanism of LKB1 on non-small cell lung cancer (NSCLC) A549 cells. Material and Methods A549 cells were divided into control group, LKB1 negative control (NC) group, LKB1 group, ERK inhibitor group and LKB1 + ERK activator group. Cell proliferation and apoptosis were detected by cell counting kit (CCK-8)...
Hassan, Mohammed H. Abuhamdah, Sawsan Abdel-Bary, Mohamed Wahman, Mohammed Abd-Elhamid, Tarek Hamdy Beshay, Morris Mosallam, Karam Elsadek, Bakheet E.M.
Published in
Bioscience Reports
Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the expression levels of survivin and fibulin-3 in benign and malignant respiratory diseases. This case–control study included 219 pat...
Kovaleva, Olga V. Rashidova, Madina A. Samoilova, Daria V. Podlesnaya, Polina A. Tabiev, Rasul M. Mochalnikova, Valeria V. Gratchev, Alexei
Published in
International Journal of Molecular Sciences
There is an urgent need for identification of new prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). In this study, we evaluated immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis revealed no prognostic value for the markers studied, except CD163 and CD206. At the same time, macrophage markers ...
Ahluwalia, Pankaj Ahluwalia, Meenakshi Mondal, Ashis K. Sahajpal, Nikhil Kota, Vamsi Rojiani, Mumtaz V. Rojiani, Amyn M. Kolhe, Ravindra
Published in
Cancers
Simple Summary The human body consists of trillions of cells and several million of them die daily. These natural processes which determine the fate of a cell in the human body can be broadly defined as programmed cell death (apoptosis and autophagy) and a non-programmed, passive cell death (necrosis). The inherent genetic diversity in humans and d...
