Carrasco-Reinado, Rafael Escobar-Niño, Almudena Fajardo, Carlos Morano, Ines M Amil-Ruiz, Francisco Martinez-Rodríguez, Gonzalo Fuentes-Almagro, Carlos Capilla, Victoria Tomás-Cobos, Lidia Soriano-Romaní, Laura
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Published in
International journal of molecular sciences
Proteomics is a crucial tool for unravelling the molecular dynamics of essential biological processes, becoming a pivotal technique for basic and applied research. Diverse bioinformatic tools are required to manage and explore the huge amount of information obtained from a single proteomics experiment. Thus, functional annotation and protein-protei...
Rafi, Md Oliullah Bhattacharje, Gourab Al-Khafaji, Khattab Taskin-Tok, Tugba Alfasane, Md Almujaddade Das, Amit Kumar Parvez, Md Anowar Khasru Rahman, Md Shahedur
Published in
Journal of biomolecular structure & dynamics
Pandemic COVID-19 infections have spread throughout the world. There is no effective treatment against this disease. Viral RNA-dependent RNA polymerase (RdRp) catalyzes the replication of RNA from RNA and the main protease (Mpro) has a role in the processing of polyproteins that are translated from the RNA of SARS-CoV-2, and thus these two enzymes ...
Fadaka, Adewale Oluwaseun Aruleba, Raphael Taiwo Sibuyi, Nicole Remaliah Samantha Klein, Ashwil Madiehe, Abram Madimabe Meyer, Mervin
Published in
Journal of biomolecular structure & dynamics
The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated the inhibitory effects of Pradimicin A, Lamivudine, Plerixafor and Lopinavir against SARS-CoV-2 Mpro. ADME/Tox of the ligands, pha...
Qin, Chaolong Feng, Wanshan Chu, YenJu Lee, Jong Bong Berton, Mattia Bettonte, Sara Teo, Yeong Yeu Stocks, Michael J Fischer, Peter M Gershkovich, Pavel
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Published in
Biomedical chromatography : BMC
A simple, sensitive and cost-effective HPLC-UV bioanalytical method for determination of lopinavir (LPV) in rat and human plasma was developed and validated. The plasma sample preparation procedure includes a combination of protein precipitation using cold acetonitrile and liquid-liquid extraction with n-hexane-ethyl acetate (7:3, v/v). A good chro...
Bhattacharyya, Anusuya Kumar, Subodh Sarma, Phulen Kaur, Hardeep Prajapat, Manisha Shekhar, Nishant Bansal, Seema Avti, Pramod Hazarika, Mythili Sharma, Saurabh
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Published in
Indian journal of pharmacology
Being protease inhibitors and owing to their efficacy in SARS-CoV, lopinavir + ritonavir (L/R) combination is being used in the management of COVID-19. In this systematic review and meta-analysis, we have evaluated the comparative safety and efficacy of L/R combination. Comparative, observational studies and controlled clinical trials comparing L/R...
Stanković, Biljana Kotur, Nikola Gašić, Vladimir Klaassen, Kristel Ristivojević, Bojan Stojiljković, Maja Pavlović, Sonja Zukić, Branka
Published in
Journal of Medical Biochemistry
Background Since there are no certified therapeutics to treat COVID-19 patients, drug repurposing became important. With lack of time to test individual pharmacogenomics markers, population pharmacogenomics could be helpful in predicting a higher risk of developing adverse reactions and treatment failure in COVID-19 patients. Aim of our study was t...
Kariyawasam, Dulanjalee Peries, Marianne Foissac, Frantz Eymard-Duvernay, Sabrina Tylleskär, Thorkild Singata-Madliki, Mandisa Kankasa, Chipepo Meda, Nicolas Tumwine, James Mwiya, Mwiya
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Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Perinatal treatment with lopinavir boosted by ritonavir (LPV/r) is associated with steroidogenic abnormalities. Long-term effects in infants have not been studied. Adrenal-hormone profiles were compared at weeks 6 and 26 between human immunodeficiency virus (HIV)-1-exposed but uninfected infants randomly assigned at 7 days of life to prophylaxis wi...
Giacomelli, Andrea Pagani, Gabriele Ridolfo, Anna Lisa Oreni, Letizia Conti, Federico Pezzati, Laura Bradanini, Lucia Casalini, Giacomo Bassoli, Cinzia Morena, Valentina
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Published in
Journal of Medical Virology
Background As it has been shown that lopinavir (LPV) and hydroxychloroquine (HCQ) have in vitro activity against coronaviruses, they were used to treat COVID‐19 during the first wave of the epidemic in Lombardy, Italy. Methods To compare the rate of clinical improvement between those who started LPV/ritonavir (LPV/r)+HCQ within five days of symptom...
Thakur, Aarzoo Tan, Shawn Pei Feng Chan, James Chun Yip
Published in
Clinical Pharmacology and Therapeutics
Lopinavir/ritonavir, originally developed for treating the human immunodeficiency virus (HIV), is currently undergoing clinical studies for treating the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although recent reports suggest that lopinavir exhibits in vitro efficacy against SARS‐CoV‐2, it is a highly protein bound drug and it ...
Kala, Smriti Dunk, Caroline Acosta, Sebastian Serghides, Lena
Published in
Human reproduction (Oxford, England)
Does HIV protease inhibitor (PI)-based combination antiretroviral therapy (cART) initiated at periconception affect key events in early pregnancy, i.e. decidualization and spiral artery remodeling? Two PIs, lopinavir and darunavir, currently offered as cART options in HIV-positive pregnancies were evaluated, and we found that lopinavir-based cART, ...
