plácido, ana i. azevedo, daniela herdeiro, maria teresa morgado, manuel roque, fátima
Irisin is a protein resulting from a proteolytic cleavage of fibronectin type III domain-containing protein 5 (FND5). The ability of irisin to modulate adipocyte and control glucose metabolism in human metabolic diseases gave rise to the hypothesis that irisin could have a pivotal role in aging-related diseases. Although in animal models, increased...
dewulf, manon duchateau, luc meesters, maya martens, dries s. nawrot, tim s. van eetvelde, mieke opsomer, geert
Telomere length (TL) has gained attention as a biomarker for longevity and productivity in dairy cattle. This study explored the association between neonatal TL in Holstein calves and lifetime parameters (lifespan, milk production, and reproduction). Blood samples were collected from 210 calves (≤10d old) across four dairy farms in Flanders, Belgiu...
waters, david j. maras, aimee h. rong, fu carrillo, andres e. chiang, emily c. suckow, cheri l.
Frailty refers to a state of increased vulnerability to mortality and other adverse outcomes as a consequence of age-related decline in physiologic reserve and function. Comparative biomedical scientists are relied upon to innovate approaches to enhance understanding of the similarities and differences between humans and other animal species that c...
schmidhäuser, paul inhofer, max buchholz, annika mais, franziska miehe, robert
Implementing sustainability strategies is essential for the future viability of companies. While companies have been focusing intensively on the operationalization of efficiency and consistency for quite some time, sufficiency approaches are rare. As a result, there is a lack of fundamental understanding of the concept, its inherent potential, as w...
Jiang, Nisi Cheng, Catherine J. Liu, Qianqian Strong, Randy Gelfond, Jonathan Nelson, James F.
Published in
bioRxiv
Evidence that life-extending interventions are not uniformly effective across the lifespan calls for an analytic tool that can estimate age-specific treatment effects on mortality hazards. Here we report such a tool, applying it to mouse data from 42 compounds tested in the NIA Interventions Testing Program. This tool identified agents that either ...
merinas-amo, tania merinas-amo, rocío alonso-moraga, ángeles font, rafael celestino, mercedes del río
The controversial results of research on monosodium glutamate demand a new data corpus for the overall safety evaluation. Both animal and cellular model systems have been used to add a multilevel scope on its biological effects. The Drosophila melanogaster animal model has been used to test a wide range of concentrations for safety purposes: toxici...
cloutier, laetitia galiot, lucie sauvé, béatrice pierre, carole guay, frédéric dumas, gabrielle gagnon, patrick montminy, marie-pierre létourneau
This study evaluated the impact of precision feeding and bump feeding strategies during gestation on the reproductive performance of sows monitored over three cycles. Four treatments were compared: two constant-concentration feeding strategies (0.53% standardized ileal digestible lysine content; SID Lys) with the feed supply remaining constant (fla...
accardi, giulia calabrò, anna caldarella, rosalia caruso, calogero ciaccio, marcello di simone, marta ligotti, mattia emanuela meraviglia, serena zarcone, rosa candore, giuseppina
...
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected group, having survived significant adversities, including the Spanish flu and COVID-19 pandemics, indicating distinct...
Hsu, Hung-Chieh Wu, Shih-Hsiung Shih, Chuan-Feng
Published in
Japanese Journal of Applied Physics
This research presents interfacial engineering of large-area perovskite solar modules. The quality of the interface between the electron transport layer (ETL) and the perovskite layer is studied, because it significantly affects the optoelectronic performance of large-area module devices. In large-area fabrication, film uniformity and interfacial q...
Endicott, S. Joseph
Published in
Frontiers in Aging
Chaperone-mediated autophagy (CMA) is the lysosomal degradation of individually selected proteins, independent of vesicle fusion. CMA is a central part of the proteostasis network in vertebrate cells. However, CMA is also a negative regulator of anabolism, and it degrades enzymes required for glycolysis, de novo lipogenesis, and translation at the ...
