Biancalana, Lorenzo Batchelor, Lucinda K Pereira, Sarah A P Tseng, Po-Jen Zacchini, Stefano Pampaloni, Guido Saraiva, Lúcia M F S Dyson, Paul J Marchetti, Fabio
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
A facile route to PtII complexes doubly functionalized with bioactive molecules through a bipyridine-type ligand is described. Initially, ligands LEE (containing two ethacrynic acid units), LEF (ethacrynic acid+flurbiprofen) and LEB (ethacrynic acid+biotin) were obtained in moderate to good yields from 2,2'-bipyridine-4,4'-dicarboxylic acid. Subseq...
Lin, Tao-Yan Pan, Zhangjin Tu, Youshao Zhu, Shuai Wu, Hai-Hong Liu, Yu Li, Zhiming Zhang, Junliang
Published in
Angewandte Chemie (International ed. in English)
The first example of highly enantioselective fluoroarylation of gem-difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine (Sadphos) type ligand TY-Phos. N-Me-TY-Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily...
Andris, Erik Segers, Koen Mehara, Jaya Rulíšek, Lubomír Roithová, Jana
Published in
Angewandte Chemie (International ed. in English)
Iron(IV)-oxo intermediates in nature contain two unpaired electrons in the Fe-O antibonding orbitals, which are thought to contribute to their high reactivity. To challenge this hypothesis, we designed and synthesized closed-shell singlet iron(IV) oxo complex [(quinisox)Fe(O)]+ (1+ ; quinisox-H=(N-(2-(2-isoxazoline-3-yl)phenyl)quinoline-8-carboxami...
Daugulis, Olafs Brookhart, Maurice Janeta, Mateusz Heidlas, Julius X
Published in
Angewandte Chemie (International ed. in English)
The reactivity of Ni(II) and Pd(II) olefin polymerization catalysts can be enhanced by introduction of electron-withdrawing substituents on the supporting ligands rendering the metal centers more electrophilic. Reported here is a comparison of ethylene polymerization activity of a classical salicyliminato nickel catalyst substituted with the powerf...
Ayhan, M Menaf Bayraktar, Ceyda Yu, Kai Bin Hanna, Gabriel Yazaydin, A Ozgur Zorlu, Yunus Yücesan, Gündoğ
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
A one-dimensional nanotubular metal-organic framework (MOF) [Ni(Cu-H4 TPPA)]⋅2 (CH3 )2 NH2 + (H8 TPPA=5,10,15,20-tetrakis[p-phenylphosphonic acid] porphyrin) constructed by using the arylphosphonic acid H8 TPPA is reported. The structure of this MOF, known as GTUB-4, was solved by using single-crystal X-ray diffraction and its geometric accessible ...
Kim, Hyunho Kim, Minseop Song, Hayoung Lee, Eunsung
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
The synthesis of ambiphilic N-heterocyclic carbene ligand, indol-2-ylidene (IdY, A ), is described, as a series of indolenium precursors ( 2a - f ) were prepared on a gram scale in good yields. Trapping experiments with elemental selenium, [RhCl(cod)] 2 and CuCl provided the expected carbene adducts. Further computational and spectroscopic studies ...
Ge, Cheng-Tong Cai, Qing-Yun Zhang, Qi-Lei Chu, Wen-Ning Yao, Shan-Jing Lin, Dong-Qiang
Published in
Journal of separation science
Human serum albumin is widely used in clinical practice, and the development of new ligands with high affinity is beneficial to improve its separation efficiency. The Site II of human serum albumin is an active binding site of various molecules such as l-tryptophan, which was studied with molecular simulation to obtain insights for the design of ne...
Redero, Pablo Hartung, Thierry Zhang, Jianwei Nicholls, Leo D M Zichen, Guo Simon, Martin Golz, Christopher Alcarazo, Manuel
Published in
Angewandte Chemie (International ed. in English)
The synthesis of unprecedented BINOL-derived cationic phosphonites is described. Through the use of these phosphanes as ancillary ligands in AuI catalysis, a highly regio- and enantioselective assembly of appropriately designed alkynes into 1-(aryl)benzo[5]carbohelicenes is achieved. The modular synthesis of these ligands and the enhanced reactivit...
Johannsen, Tim Golz, Christopher Alcarazo, Manuel
Published in
Angewandte Chemie (International Ed. in English)
A series of α‐cationic phosphole ligands has been synthesized and their use as ancillary ligands explored in Au‐catalysis. If compared with non‐heterocyclic α‐cationic phospines, higher reaction rates and better control of the stereoselectivity are obtained.
Hillenbrand, Julius Leutzsch, Markus Gordon, Christopher P. Copéret, Christophe Fürstner, Alois
Published in
Angewandte Chemie (International Ed. in English)
Silanolate ligands excel with molybdenum alkylidynes but are found to be inadequate for tungsten in that they impart undue Lewis acidity. This effect is manifested in the 183W NMR shifts, which are surprisingly easy to record by 1H,183W HMBC experiments. As a consequence, the ligand scaffold was redesigned and an unprecedented chelate alkoxide comp...
