Published in Open Medicine
ObjectiveA cluster outbreak of patients with similar symptoms and computed tomographic (CT) images of COVID-19 were diagnosed with leptospirosis. This study was aimed to identify the clinical difference between leptospirosis and COVID-19, providing evidence for strategy optimization.MethodsA cohort of leptospirosis patients were collected and compa...
ABSTRACT Bovine leptospirosis assumes great economic importance since it affects several production aspects. Therefore, knowledge about the occurrence and distribution of this disease is fundamental to adopt the correct prevention measures. The present study aimed to evaluate the frequency of anti-Leptospira spp. antibodies in 24,483 bovine serum s...
Published in Ocular immunology and inflammation
Back ground: Leptospirosis is one of the common zoonotic diseases, endemic among farmers. Globally, awareness of risk factors is reported to be very low. This study aims to quantitatively analyze the knowledge and attitude related to leptospirosis in Madurai district and to identify misconceptions that result in poor practice.Material & methods: A ...
Published in Pathogens
Leptospirosis is a perplexing conundrum for many. In the existing literature, the pathophysiological mechanisms pertaining to leptospirosis is still not understood in full. Considered as a neglected tropical zoonotic disease, leptospirosis is culminating as a serious problem worldwide, seemingly existing as co-infections with various other unrelate...
Leptospirosis, an environmental infectious disease of bacterial origin, is the infectious disease with the highest associated mortality in Seychelles. In small island territories, the occurrence of the disease is spatially heterogeneous and a better understanding of the environmental factors that contribute to the presence of the bacteria would hel...
Published in Frontiers in Immunology
Toll-Like Receptor (TLR) 4, the LPS receptor, plays a central role in the control of leptospirosis and absence of TLR4 results in lethal infection in mice. Because human TLR4 does not sense the atypical leptospiral-LPS, we hypothesized that TLR4/MD-2 humanized transgenic mice (huTLR4) may be more susceptible to leptospirosis than wild-type mice, an...
Published in Animals : an Open Access Journal from MDPI
Simple Summary The isolation of Leptospira is the most important test to assess infection in animal species. Several animals play a role as maintenance-host for specific serovars and in the last 30 years the incidence of leptospirosis has constantly increased in well-known reservoirs as well as in “unconventional” hosts. The emergence and the ident...
Published in Frontiers in Immunology
The virulence mechanisms required for infection and evasion of immunity by pathogenic Leptospira species remain poorly understood. A number of L. interrogans surface proteins have been discovered, lying at the interface between the pathogen and host. Among these proteins, the functional properties of the Lig ( l eptospiral i mmuno g lobulin-like do...
Leptospirosis, an environmental infectious disease of bacterial origin, is the infectious disease with the highest associated mortality in Seychelles. In small island territories, the occurrence of the disease is spatially heterogeneous and a better understanding of the environmental factors that contribute to the presence of the bacteria would hel...
Published in Nanomaterials
Leptospira infection can cause potential hazards to human health by stimulating inflammation, which is mediated mainly through the Toll-like receptor 2 (TLR2) pathway. Gold nanoparticles (AuNPs) are promising for medical applications, as they display both bioinert and noncytotoxic characteristics. AuNPs have been shown to have the ability to modify...
