Ammer, Tatjana Schützenmeister, André Prokosch, Hans-Ulrich Zierk, Jakob Rank, Christopher M Rauh, Manfred
Published in
Clinical chemistry
Indirect methods leverage real-world data for the estimation of reference intervals. These constitute an active field of research, and several methods have been developed recently. So far, no standardized tool for evaluation and comparison of indirect methods exists. We provide RIbench, a benchmarking suite for quantitative evaluation of any existi...
Haslam, Danielle E Li, Jun Dillon, Simon T Gu, Xuesong Cao, Yin Zeleznik, Oana A Sasamoto, Naoko Zhang, Xuehong Eliassen, A Heather Liang, Liming
...
Published in
Proteomics
Limited data exist on the performance of high-throughput proteomics profiling in epidemiological settings, including the impact of specimen collection and within-person variability over time. Thus, the Olink (972 proteins) and SOMAscan7Kv4.1 (7322 proteoforms of 6596 proteins) assays were utilized to measure protein concentrations in archived plasm...
Kushnir, Mark M Nelson, Heather A Doyle, Kelly
Published in
The journal of applied laboratory medicine
The free hormone (FH) hypothesis states that hormone action and the corresponding biological effects are mediated by the unbound (free) fraction of hormone in circulation. The in vivo relationship between protein-bound and FH is complex and dynamic. In most individuals, measurement of total hormone (TH) is usually adequate to reflect the hormone st...
Deschermeier, Christina Ehmen, Christa von Possel, Ronald Murawski, Carolin Rushton, Ben Amuasi, John Sarpong, Nimako Maiga-Ascofaré, Oumou Rakotozandrindrainy, Raphael Asogun, Danny
...
Published in
Journal of Clinical Microbiology
Sensitive and specific serological tests are mandatory for epidemiological studies evaluating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence as well as coronavirus disease 2019 (COVID-19) morbidity and mortality rates. The accuracy of results is challenged by antibody waning after convalescence and by cross-reactivity induc...
Schroeder, Lee F Bachman, Michael A Idoni, Allison Gegenheimer-Holmes, Jennifer Kronick, Steven L Valdez, Riccardo Lephart, Paul R
Published in
The journal of applied laboratory medicine
Diagnostic sensitivities of point-of-care SARS-CoV-2 assays depend on specimen type and population-specific viral loads. Evaluation of these assays require "direct" specimens from paired-swab studies rather than more accessible residual specimens in viral transport media (VTM). Residual VTM and limit-of-detection studies were conducted on Abbott ID...
Schiff, Tamar Caplan, Arthur
Published in
Clinical chemistry
Gidske, Gro Sandberg, Sverre Fossum, Anne L. Binder, Stein Langsjøen, Eva C. Solsvik, Anne E. Stavelin, Anne
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Internal quality control (IQC) plays an important role in quality assurance in laboratory medicine. However, there is no universal consensus or guideline on when and how IQC should be analyzed on point-of-care testing (POCT) devices. The aim of this study was to develop a scoring system to determine how often IQC should be analyzed in pr...
Ulmer, Candice Z Maus, Anthony Hines, Jolaine Singh, Ravinder
Published in
Clinical chemistry
Sklavounos, Alexandros A Lamanna, Julian Modi, Dimpy Gupta, Sidharth Mariakakis, Alex Callum, Jeannie Wheeler, Aaron R
Published in
Clinical chemistry
Blood typing, donor compatibility testing, and hematocrit analysis are common tests that are important in many clinical applications, including those found in high-stakes settings such as the trauma center. These tests are typically performed in centralized laboratories with sample batching; the minutes that are lost in this mode can lead to advers...
