Cao, Congcong Duan, Peng Li, Wencun Guo, Yang Zhang, Jin Gui, Yaoting Yuan, Shuiqiao
Published in
Frontiers in Cell and Developmental Biology
Non-alcoholic fatty liver disease (NAFLD) affects obesity-associated metabolic syndrome, which exhibits hepatic steatosis, insulin insensitivity and glucose intolerance. Emerging evidence suggests that microRNAs (miRNAs) are essential for the metabolic homeostasis of liver tissues. Many hepatic miRNAs located in the miR-379/miR-544 cluster were sig...
Li, Ke Feng, Tiejun Liu, Leyan Liu, Hongmei Huang, Kaixun Zhou, Jun
Published in
International journal of molecular sciences
Selenoprotein T (SELENOT, SelT), a thioredoxin-like enzyme, exerts an essential oxidoreductase activity in the endoplasmic reticulum. However, its precise function remains unknown. To gain more understanding of SELENOT function, a conventional global Selenot knockout (KO) mouse model was constructed for the first time using the CRISPR/Cas9 techniqu...
Zhang, Pu Ohkawa, Yuki Yamamoto, Satoko Momota, Hiroyuki Kato, Akira Kaneko, Kei Natsume, Atsushi Farhana, Yesmin Ohmi, Yuhsuke Okajima, Tetsuya
...
Published in
Nagoya Journal of Medical Science
Ganglioside GD3/GD2 are over-expressed in various neuroectoderm-derived tumors. Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma microenvironments. To clarify the functions of GD3...
van der Bijl, Wouter Mank, Judith E.
Published in
Evolution Letters
The majority of the genome is shared between the sexes, and it is expected that the genetic architecture of most traits is shared as well. This common architecture has been viewed as a major source of constraint on the evolution of sexual dimorphism (SD). SD is nonetheless common in nature, leading to assumptions that it results from differential r...
Li, Tuofan Xie, Jing Yao, Xiaohui Zhang, Jun Li, Chunping Ren, Dan Li, Luyuan Xie, Quan Shao, Hongxia Qin, Aijian
...
Published in
Virulence
Avian leukosis virus subgroup J (ALV-J) generally induces hemangioma, myeloid leukosis, and immunosuppression in chickens, causing significant poultry industry economic losses worldwide. The unusual env gene of ALV-J, with low homology to other subgroups of ALVs, is associated with its unique pathogenesis. However, the exact molecular basis for the...
Zeng, Ming-Hua Wang, Yan Huang, Hua-Lin Quan, Ru-Ping Yang, Jun-Ting Guo, Dan Sun, Ying Lv, Chao Li, Tian-Ying Wang, Le
...
Published in
Biology of reproduction
Zona pellucida (ZP), which is composed of at most four extracellular glycoproteins (ZP1, ZP2, ZP3, and ZP4) in mammals, shelters the oocytes and is vital in female fertility. Several studies have identified the indispensable roles of ZP1-3 in maintaining normal female fertility. However, the understanding of ZP4 is still very poor because only one ...
Abouelasrar Salama, Sara Gouwy, Mieke Van Damme, Jo Struyf, Sofie
Published in
Immunology
Serum amyloid A (SAA) is an acute-phase protein (APP) to which multiple immunological functions have been attributed. Regardless, the true biological role of SAA remains poorly understood. SAA is remarkably conserved in mammalian evolution, thereby suggesting an important biological function. Since its discovery in the 1970s, the majority of resear...
Guo, Yang Wu, Youbing Shi, Jiahao Zhuang, Hua Ci, Lei Huang, Qin Wan, Zhipeng Yang, Hua Zhang, Mengjie Tan, Yutong
...
Published in
Frontiers in Endocrinology
miR-29a/b1 was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear. In this study, female mice lacking miR-29a/b1 showed a delay in vaginal opening, irregular estrous cycles, ovulation disorder and subfertility. The level of luteinizing hormone (LH) was significant...
tokumoto, shoko miyata, yugo deviatiiarov, ruslan yamada, takahiro g. hiki, yusuke kozlova, olga yoshida, yuki cornette, richard funahashi, akira shagimardanova, elena
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The Pv11, an insect cell line established from the midge Polypedilum vanderplanki, is capable of extreme hypometabolic desiccation tolerance, so-called anhydrobiosis. We previously discovered that heat shock factor 1 (HSF1) contributes to the acquisition of desiccation tolerance by Pv11 cells, but the mechanistic details have yet to be elucidated. ...
künstner, axel aherrahrou, redouane hirose, misa bruse, petra ibrahim, saleh mohamed busch, hauke erdmann, jeanette aherrahrou, zouhair
CYP17A1 is a cytochrome P450 enzyme that has 17-alpha-hydroxylase and C17,20-lyase activities. Cyp17a11 deficiency is associated with high body mass and visceral fat deposition in atherosclerotic female ApoE knockout (KO, d/d or -/-) mice. In the present study, we aimed to investigate the effects of diet and Cyp17a1 genotype on the gut microbiome. ...
