Fuller, Mark T. Dadoo, Omid Xiong, Ting Chivukula, Pardh MacDonald, Melissa E. Lee, Samuel K. Austin, Richard C. Igdoura, Suleiman A. Trigatti, Bernardo L.
Published in
Frontiers in Physiology
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL receptor and apolipoprotein E, are widely used models of experimental atherosclerosis. Converse...
Flórez, Julio M. Martins, Kyra Solin, Staci Bostrom, Jonathan R. Rodríguez-Villamil, Paula Ongaratto, Felipe Larson, Sabreena A. Ganbaatar, Uyanga Coutts, Alexander W. Kern, Doug
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Published in
Frontiers in Genetics
Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare concern in swine production. Disrupting porcine KISS1 is hypothesized to delay or abolish puberty by inducing variable hypogonadotropism and thus preventing the need for castration. M...
Mitra, Sicon Anand, Uttpal Ghorai, Mimosa Kant, Nishi Kumar, Manoj Radha, Jha, Niraj K Swamy, Mallappa K Proćków, Jarosław de la Lastra, José M Pérez
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Published in
Biotechnology and bioengineering
Plants produce a large number of secondary metabolites, known as phytometabolites that may be employed as medicines, dyes, poisons, and insecticides in the field of medicine, agriculture, and industrial use, respectively. The rise of genome management approaches has promised a factual revolution in genetic engineering. Targeted genome editing in li...
Paunovska, Kalina Da Silva Sanchez, Alejandro J Lokugamage, Melissa P Loughrey, David Echeverri, Elisa Schrader Cristian, Ana Hatit, Marine Z C Santangelo, Philip J Zhao, Kun Dahlman, James E
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Published in
Nano letters
Lipid nanoparticles (LNPs) have delivered therapeutic RNA to hepatocytes in humans. Adsorption of apolipoprotein E (ApoE) onto these clinical LNP-mRNA drugs has been shown to facilitate hepatocyte entry via the low-density lipoprotein receptor (LDLR). Since ApoE-LDLR trafficking is conserved in mice, non-human primates, and humans, characterizing t...
Sweetman, Crystal Waterman, Christopher D. Wong, Darren C.J. Day, David A. Jenkins, Colin L.D. Soole, Kathleen L.
Published in
Frontiers in Plant Science
Stress-responsive components of the mitochondrial alternative electron transport pathway have the capacity to improve tolerance of plants to abiotic stress, particularly the alternative oxidase AOX1A but also external NAD(P)H dehydrogenases such as NDB2, in Arabidopsis. NDB2 and AOX1A can cooperate to entirely circumvent the classical electron tran...
Khan, Muhammad Sarwar Riaz, Rimsha Majid, Muhammad Mehmood, Kashif Mustafa, Ghulam Joyia, Faiz Ahmad
Published in
Frontiers in Plant Science
A tobacco chloroplast hypothetical open reading frame 4 (YCF4) has been reported as a non-essential assembly factor for photosynthesis based on an incomplete knockout of YCF4, just 93 of 184 amino acids from the N-terminus were knocked out. On the other hand, we removed the complete sequence of YCF4 from tobacco chloroplasts and observed that ΔYCF4...
Hu, Yan Pan, Xiangyu Shi, Yu Qiu, Yuanhui Wang, Liqun Murawala, Prayag Liu, Yanmei Xing, Wanjin Tanaka, Elly M. Fei, Ji-Feng
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Published in
Frontiers in Genetics
Regeneration of a complex appendage structure such as limb requires upstream and downstream coordination of multiple types of cells. Given type of cell may sit at higher upstream position to control the activities of other cells. Muscles are one of the major cell masses in limbs. However, the subtle functional relationship between muscle and other ...
Alpizar-Sosa, Edubiel A. Kumordzi, Yasmine Wei, Wenbin Whitfield, Phillip D. Barrett, Michael P. Denny, Paul W.
Published in
Frontiers in Cellular and Infection Microbiology
With the global reach of the Neglected Tropical Disease leishmaniasis increasing, coupled with a tiny armory of therapeutics which all have problems with resistance, cost, toxicity and/or administration, the validation of new drug targets in the causative insect vector borne protozoa Leishmania spp is more important than ever. Before the introducti...
Li, Yunfeng Zhu, Jiaqi Feng, Yixuan Li, Zhenfeng Ren, Zheng Liu, Ning Liu, Chaojie Hao, Jinghong Han, Yingyan
Published in
Frontiers in Plant Science
Lettuce (Lactuca sativa L.) is a leafy vegetable whose edible organs usually are leaf or stems, and thus high-temperature induced bolting followed by flower initiation is an undesirable trait in lettuce production. However, the molecular mechanism that controls lettuce bolting and flowering upon thermal treatments is largely unknown. Here, we ident...
Zhan, Yongqiang Xu, Dongwei Tian, Yizhu Qu, Xiaoye Sheng, Mingwei Lin, Yuanbang Ke, Michael Jiang, Longfeng Xia, Qiang Kaldas, Fady M
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Background & aimsThe stimulator of interferon genes (STING)/TANK-binding kinase 1 (TBK1) pathway is vital in mediating innate immune and inflammatory responses during oxidative/endoplasmic reticulum (ER) stress. However, it remains unknown whether macrophage thioredoxin-interacting protein (TXNIP) may regulate TBK1 function and cell death pathways ...
