Rother, Tamina Horgby, Carina Schmalkuche, Katharina Burgmann, Jonathan M. Nocke, Fabian Jägers, Johannes Schmitz, Jessica Bräsen, Jan Hinrich Cantore, Miriam Zal, Franck
...
Published in
Frontiers in Transplantation
Normothermic ex-vivo machine perfusion provides a powerful tool to improve donor kidney preservation and a route for the delivery of pharmacological or gene therapeutic interventions prior to transplantation. However, perfusion at normothermic temperatures requires adequate tissue oxygenation to meet the physiological metabolic demand. For this pur...
Foguenne, Maxime MacMillan, Serena Kron, Philipp Nath, Jay Devresse, Arnaud De Meyer, Martine Michel, Mourad Hosgood, Sarah Darius, Tom
Peer reviewed: True / The use of high-risk renal grafts for transplantation requires the optimization of pretransplant assessment and preservation reconditioning strategies to decrease the organ discard rate and to improve short- and long-term clinical outcomes. Active oxygenation is increasingly recognized to play a central role in dynamic preserv...
Akalay, Sara; 149721; Hosgood, Sarah A;
The increasing number of patients on the kidney transplant waiting list underlines the need to expand the donor pool and improve kidney graft utilization. By protecting kidney grafts adequately from the initial ischemic and subsequent reperfusion injury occurring during transplantation, both the number and quality of kidney grafts could be improved...
Akalay, Sara Hosgood, Sarah A
Peer reviewed: True / The increasing number of patients on the kidney transplant waiting list underlines the need to expand the donor pool and improve kidney graft utilization. By protecting kidney grafts adequately from the initial ischemic and subsequent reperfusion injury occurring during transplantation, both the number and quality of kidney gr...
edgworth;, eileen
Normothermic machine perfusion (NMP) of kidneys in combination with an optimized perfusate composition may increase donor organ preservation quality, especially in the case of marginal donor grafts. Optimization of currently employed perfusates is still a subject of present research. Due to the advantages of being cell-free, easy to store, and havi...
van Leeuwen, L. Leonie Spraakman, Nora A. Brat, Aukje Huang, Honglei Thorne, Adam M. Bonham, Sarah van Balkom, Bas W. M. Ploeg, Rutger J. Kessler, Benedikt M. Leuvenink, Henri G.D.
...
Published in
Transplant International
Experimental design, workflow and results. Elevated complement, cytoskeleton and lipid metabolism proteins were identified.
juriasingani;, smriti
The use of blood for normothermic and subnormothermic kidney preservation hinders the translation of these approaches and promising therapeutics. This study evaluates whether adding hydrogen sulfide donor AP39 to Hemopure, a blood substitute, during subnormothermic perfusion improves kidney outcomes. After 30 min of renal pedicle clamping, porcine ...
juriasingani;, smriti
Cold preservation is the standard of care for renal grafts. However, research on alternatives like perfusion at higher temperatures and supplementing preservation solutions with hydrogen sulfide (H2S) has gained momentum. In this study, we investigated whether adding H2S donor AP39 to porcine blood during subnormothermic perfusion at 21 °C improves...
Stryjak, Iga Warmuzińska, Natalia Bogusiewicz, Joanna Łuczykowski, Kamil Bojko, Barbara
Published in
Journal of separation science
The limiting factor in conventional quality assessments of transplanted organs, namely the invasiveness of tissue sample collection, has prompted much research on the field of transplantology to focus on the development of alternative evaluation methods of organ quality. In the present project, we undertake the challenge to address the need for a n...
De Beule, Julie Jochmans, Ina
Published in
Journal of Clinical Medicine
The final decision to accept an organ for transplantation remains a subjective one. With “poor organ quality” commonly cited as a major reason for kidney discard, accurate, objective, and reliable quality assessment is essential. In an era of increasingly higher-risk deceased donor kidneys, the catch is to accept those where the risk–benefit scale ...
