Michael, Mini Groothoff, Jaap W Shasha-Lavsky, Hadas Lieske, John C Frishberg, Yaacov Simkova, Eva Sellier-Leclerc, Anne-Laure Devresse, Arnaud Guebre-Egziabher, Fitsum Bakkaloglu, Sevcan A
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Published in
American journal of kidney diseases : the official journal of the National Kidney Foundation
Lumasiran reduces urinary and plasma oxalate (POx) in patients with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ILLUMINATE-C evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of lumasiran in patients with PH1 and advanced kidney disease. Phase 3, open-label, single-arm trial. Multinational study...
Pays, Etienne Radwanska, Magdalena Magez, Stefan
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also pr...
Yang, Yuanting Cheng, Jiayi Lin, Qisheng Ni, Zhaohui
Published in
Frontiers in Medicine
Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc–), lipid metabolism, and iron metabolis...
Das, Kuntal Muthukumar, A. Almuqbil, Mansour Imran, Mohd. Rabaan, Ali A. Halwani, Muhammad A. Garout, Mohammed Alsaleh, Abdulmonem A. Alissa, Mohammed Alwashmi, Ameen S. S.
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Published in
Frontiers in Pharmacology
This study was done to investigate the possible nephroprotective effect of an ethanolic root extract of Polyalthia Longifolia (PL) on vancomycin-induced nephrotoxicity using curative and protective models. Vancomycin (150 mg/kg, intravenous) was given to healthy Wistar albino rats in the curative model before the start of treatment, whereas the pro...
morrissey, austin p. elzinad, nagla el hayek, chris lotfollahzadeh, saran chitalia, vipul c.
COVID-19 is a devastating systemic disease characterized by multisystem involvement driven by exuberant hyperinflammatory and dysregulations in coagulation. In COVID-19 patients, renal failure contributes to morbidity and mortality, and its early detection and timely management are critical to minimize such untoward and irreversible complications. ...
donate-correa, javier martín-carro, beatriz cannata-andía, jorge b. mora-fernández, carmen navarro-gonzález, juan f.
Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be of great significance...
giglio, rosaria vincenza patti, angelo maria rizvi, ali abbas stoian, anca panta ciaccio, marcello papanas, nikolaos janez, andrej sonmez, alper banach, maciej sahebkar, amirhossein
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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. Its pathogenesis encompasses functional alterations involving elevated intraglomerular and systemic pressure, increased activity of the renin-angiotensin system (RAS) and oxidative stress, and the eventual development of renal fibrosis. The management of DN ...
aminde, leopold ndemnge wanjau, mary njeri cobiac, linda j. veerman, j. lennert
Excess sodium intake raises blood pressure which increases the risk of chronic kidney disease (CKD). We aimed to estimate the impact of reduced sodium intake on future CKD burden in Australia. A multi-cohort proportional multistate lifetable model was developed to estimate the potential impact on CKD burden and health expenditure if the Australian ...
Hun, Marady Wen, Huai Han, Phanna Vun, Tharith Zhao, Mingyi He, Qingnan
Published in
Frontiers in Cell and Developmental Biology
Background: In recent years, there has been an increasing interest in using extracellular vesicles (EVs) as potential therapeutic agents or natural drug delivery systems in kidney-related diseases. However, a detailed and targeted report on the current condition of extracellular vesicle research in kidney-related diseases is lacking. Therefore, thi...
McFarlane, Catherine Kelly, Jaimon T Conley, Marguerite Johnson, David W Campbell, Katrina L
Published in
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Nutrition supplementation, including prebiotics and probiotics, is a therapeutic strategy for modulating the gut microbiome in chronic kidney disease (CKD). However, the acceptability of gut-targeted supplements in this population remains largely unexplored. This study aims to describe the perceptions of nutrition supplementation, and the acceptabi...
