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Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.

Published in Genetics

Filamins are highly conserved actin-crosslinking proteins that regulate organization of the actin cytoskeleton. As key components of versatile signaling scaffolds, filamins are implicated in developmental anomalies and cancer. Multiple isoforms of filamins exist, raising the possibility of distinct functions for each isoform during development and ...