Moroni, Barbara Granados Torres, José Enrique López-Olvera, Jorge Ramón Espinosa Cerrato, José Ráez Bravo, Arián Mentaberre, Gregorio Fandos, Paulino Pazzi, Marco Romagnoli, Monica Gardini, Giulia
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Published in
Frontiers in Veterinary Science
Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacok...
Azam, Faizul Taban, Ismail M Eid, Eltayeb E M Iqbal, Muzaffar Alam, Ozair Khan, Shamshir Mahmood, Danish Anwar, Md Jamir Khalilullah, Habibullah Khan, M U
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Published in
Journal of biomolecular structure & dynamics
Ivermectin (IVM) is a broad-spectrum antiparasitic agent, having inhibitory potential against wide range of viral infections. It has also been found to hamper SARS-CoV-2 replication in vitro, and its precise mechanism of action against SARS-CoV-2 is yet to be understood. IVM is known to interact with host importin (IMP)α directly and averts interac...
Schellack, Natalie Strydom, Morné Pepper, Michael S Herd, Candice L Hendricks, Candice Laverne Bronkhorst, Elmien Meyer, Johanna C Padayachee, Neelaveni Bangalee, Varsha Truter, Ilse
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Published in
Antibiotics (Basel, Switzerland)
The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This study sought to ascertain links between social media reports and utilization for three re-purposed medicines: hydroxychloroquine (HC...
Jada, Stephen Raimon Dusabimana, Alfred Abd-Elfarag, Gasim Okaro, Samuel Brusselaers, Nele Carter, Jane Y Logora, Makoy Yibi Rovarini, Jacopo Mattia Newton, Charles R Colebunders, Robert
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Published in
Pathogens (Basel, Switzerland)
A two-phase survey of epilepsy was conducted in selected villages in Mundri West and East Counties (26 June-8 July, 2021), an onchocerciasis-endemic area in Western Equatoria State in South Sudan. In the first phase, households were visited by a trained research team to identify persons suspected to have epilepsy. In the second phase, persons suspe...
Roman, Yuani M Burela, Paula Alejandra Pasupuleti, Vinay Piscoya, Alejandro Vidal, Jose E Hernandez, Adrian V
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
We systematically assessed benefits and harms of the use of ivermectin (IVM) in patients with coronavirus disease 2019 (COVID-19). Published and preprint randomized controlled trials (RCTs) assessing the effects of IVM on adult patients with COVID-19 were searched until 22 March 2021 in 5 engines. Primary outcomes were all-cause mortality rate, len...
Kositz, Christian Bradley, John Hutchins, Harry Last, Anna D'Alessandro, Umberto Marks, Michael
Published in
Transactions of the Royal Society of Tropical Medicine and Hygiene
Ivermectin is a broad-spectrum antiparasitic agent that interferes with glutamate-gated chloride channels found in invertebrates but not in vertebrate species. Mass drug administration (MDA) with ivermectin-based regimes has been a mainstay of elimination efforts targeting onchocerciasis and lymphatic filariasis for more than 3 decades. More recent...
Martinez, Jose Dario Soria Orozco, Manuel Cardenas-de la Garza, Jesus Alberto
Published in
The Journal of dermatological treatment
Red scrotum syndrome is an infrequently reported dermatosis characterized by scrotal erythema accompanied by burning, pain, or dysesthesia. It has been increasingly associated with prolonged use of topical corticosteroids. Treatment is challenging and symptoms may persist for months or years after discontinuation of the topical corticosteroids. We ...
O'Mathúna, Dónal P.
Published in
Frontiers in Public Health
The COVID-19 pandemic has been characterized by a lack of clear evidence to guide healthcare professionals, the public and policymakers. The resulting uncertainty, coupled with changing guidelines as additional evidence became available, added to the stress and anxiety reported by decision-makers. Research results are key to providing evidence to g...
Sen Gupta, Parth Sarthi Biswal, Satyaranjan Panda, Saroj Kumar Ray, Abhik Kumar Rana, Malay Kumar
Published in
Journal of biomolecular structure & dynamics
While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by ∼5000 folds within 48 h, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro effective drug are unknown yet. Among 12 different COVID-19 targets along with Importin-α studied here, the RNA...
Mayer, Marcos Alejandro Krolewiecki, Alejandro Ferrero, Alejandro Bocchio, Marcelo Barbero, Juan Miguel, Marcos Paladini, Ariel Delgado, Carlos Ojeda, Juan Ramón Elorza, Claudia
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Published in
Frontiers in Public Health
Background In the absence of antiviral alternatives, interventions under research for COVID-19 might be offered following guidelines from WHO for monitored emergency use of unregistered and experimental interventions (MEURI). Ivermectin is among several drugs explored for its role against SARS-CoV-2, with a well-known safety profile but conflicting...
