Nordestgaard, Liv T Christoffersen, Mette Afzal, Shoaib Nordestgaard, Børge G Tybjærg-Hansen, Anne Frikke-Schmidt, Ruth
Published in
Clinical chemistry
Risk factors for atherosclerotic cardiovascular disease such as smoking, hypertension, physical inactivity, and diabetes have also been associated with risk of dementia. Whether hypertriglyceridemia represents a shared risk factor as well remains unknown. We tested the hypothesis that hypertriglyceridemia is associated with increased risk of non-Al...
Dave, Kandarp M. Zhao, Wanzhu Hoover, Catherine D’Souza, Anisha S Manickam, Devika
Published in
AAPS PharmSciTech
Engineered cell-derived extracellular vesicles (EVs) such as exosomes and microvesicles hold immense potential as safe and efficient drug carriers due to their lower immunogenicity and inherent homing capabilities to target cells. In addition to innate vesicular cargo such as lipids, proteins, and nucleic acids, EVs are also known to contain functi...
Luo, Yun Chen, Jie Yan, Xiu-Li Jin, Hang Sun, Xin Guo, Zhen-Ni Yang, Yi
Published in
Current neurovascular research
Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear. Thus, we aimed to assess the associatio...
Holmes, Aleah Xu, Yan Lee, Juneyoung Maniskas, Michael E Zhu, Liang McCullough, Louise D Venna, Venugopal Reddy
Published in
International journal of molecular sciences
Social isolation and loneliness are risk factors for stroke. Elderly women are more likely to be isolated. Census data shows that in homeowners over the age of 65, women are much more likely to live alone. However, the underlying mechanisms of the detrimental effects of isolation have not been well studied in older females. In this study, we hypoth...
Gychka, Sergiy G Shults, Nataliia V Nikolaienko, Sofia I Marcocci, Lucia Sariipek, Nurefsan E Rybka, Vladyslava Malysheva, Tatiana A Dibrova, Vyacheslav A Suzuki, Yuichiro J Gavrish, Alexander S
...
Published in
International journal of molecular sciences
Ischemic stroke is a major cause of death among patients with systemic hypertension. The narrowing of the lumen of the brain vasculature contributes to the increased incidence of stroke. While hyalinosis represents the major pathological lesions contributing to vascular lumen narrowing and stroke, the pathogenic mechanism of brain vascular hyalinos...
Tang, Ying Liu, Jinchang Wang, Yu Yang, Li Han, Bing Zhang, Yuan Bai, Ying Shen, Ling Li, Mingyue Jiang, Teng
...
Published in
Autophagy
Stroke is a major public health problem leading to high rates of death and disability worldwide, but no effective pharmacological therapy is currently available except for the use of PLAT (plasminogen activator, tissue). Here we show that PARP14 (poly (ADP-ribose) polymerase family, member 14) level was significantly increased in the peri-infarct z...
Tuttolomondo, Antonino Puleo, Maria Grazia Velardo, Maria Chiara Corpora, Francesca Daidone, Mario Pinto, Antonio
Published in
International journal of molecular sciences
Among the causes of global death and disability, ischemic stroke (also known as cerebral ischemia) plays a pivotal role, by determining the highest number of worldwide mortality, behind cardiomyopathies, affecting 30 million people. The etiopathogenetic burden of a cerebrovascular accident could be brain ischemia (~80%) or intracranial hemorrhage (...
McCarty, Mark F Lerner, Aaron
Published in
Expert review of neurotherapeutics
Introduction: Ischemic stroke and traumatic brain injury are leading causes of acute mortality, and in the longer run, major causes of significant mental and physical impairment. Most of the brain neuronal cell death in the minutes and hours following an ischemic stroke or brain trauma is mediated by the process of excitotoxicity, in which sustaine...
Winek, Katarzyna Lobentanzer, Sebastian Nadorp, Bettina Dubnov, Serafima Dames, Claudia Jagdmann, Sandra Moshitzky, Gilli Hotter, Benjamin Meisel, Christian Greenberg, David S
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance between inflammatory responses and immune suppression, tipping the scale between brain protection and susceptibility to infection. Peripheral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regulators are unknown. He...
Wetmore, James B Herzog, Charles A Sexter, Anne Gilbertson, David T Liu, Jiannong Kasner, Scott E
Published in
American journal of kidney diseases : the official journal of the National Kidney Foundation
The associations between ischemic stroke and time to dialysis initiation and/or death in adults with late-stage chronic kidney disease (CKD) have not been explored. We sought to measure the rate and factors associated with stroke in CKD stages 4 and 5 (CKD4-5) and assess the association of stroke with initiation of dialysis and death. Retrospective...
