The effects of zileuton and montelukast in reperfusion-induced arrhythmias in anesthetized rats.
Published in Current therapeutic research, clinical and experimental
5-Lipoxygenase is an enzyme involved in the synthesis of leukotriene eicosanoids from arachidonic acid. The therapeutic potential of zileuton, an inhibitor of 5-lipoxygenase, and montelukast, a cysteinyl leukotriene receptor antagonist, for the treatment of ischemia/reperfusion (I/R) injury of the heart has been proposed in a few studies. However, ...
