Published in Frontiers in Oncology
High-risk human papillomaviruses (HPVs) cause virtually all cervical cancer cases and are also associated with other types of anogenital and oropharyngeal cancers. Normally, HPV exists as a circular episomal DNA in the infected cell. However, in some instances, it integrates into the human genome in such a way as to enable increased expression of v...
Published in Inflammatory bowel diseases
The proportion of inflammatory bowel disease patients with ≥5 computed tomographies of the abdomen annually has increased by 2.4%-3.8% from 2010 to 2019. Age ≥50 years, men, African Americans, public insurance payors, body mass index ≥30kg/m2, and smoking history were associated with ≥5 computed tomographies of the abdomen annually.
Published in Frontiers in Immunology
Central nervous system (CNS) damage by galactic cosmic ray radiation is a major health risk for human deep space exploration. Simulated galactic cosmic rays or their components, especially high Z-high energy particles such as 56Fe ions, cause neurodegeneration and neuroinflammation in rodent models. CNS damage can be partially mediated by the blood...
Published in Frontiers in Oncology
A critical risk factor for head and neck squamous cell carcinoma (HNSCC), particularly of the oropharynx, and the response to radiotherapy is human papillomavirus (HPV) type-16/18 infection. Specifically, HPV-positive HNSCC display increased radiosensitivity and improved outcomes, which has been linked with defective signalling and repair of DNA do...
Published in Frontiers in Physiology
With the advancement in space exploration and the intention to establish an inhabitable human settlement on Mars, it is important to investigate the effects of exposure to space/microgravity and the associated radiations on procreation. Sperm function and integrity are fundamental to male reproduction and can potentially be affected by the environm...
Published in Frontiers in Cellular Neuroscience
Since their discovery in 1895, many studies have been conducted to understand the effect of X-rays on neural function and behavior in animals. These studies examined a range of acute and chronic effects, and a subset of studies has attempted to determine if X-rays can produce any sensory responses. Here we review literature on animal behavioral res...
The beta decay of 151Sm was measured by means of a metallic magnetic calorimeter. The measurement and subsequent analysis yielded a beta spectrum with an outstanding high-energy resolution of about 70 eV (FWHM) at 22 keV and a very low energy threshold well below 400 eV. The spectrum exhibited unexpectedly elevated beta emission probabilities at ve...
Published in Frontiers in Pharmacology
Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different dose regimens on gastrointestinal damage induced by high doses of gamma radiation. Material and method...
Published in Frontiers in Molecular Biosciences
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet. In this study, using HILIC affinity enrichment combined with MS analysis, we conducted a quantitative analysis of the methylated proteins in HEK293T cells in response to IR treatment. I...
Published in Japanese Journal of Applied Physics
A simple dose calculation tool, SiDE, was developed for dose evaluation in a water phantom for boron neutron capture therapy, which makes the calculation time much shorter compared with the conventional particle transportation Monte Carlo codes and is applicable to any type of incident neutron spectra to the phantom. As the SiDE can not only calcul...
