McHugh, Alexander D Chase, J Geoffrey Knopp, Jennifer L Zhou, Tony Holder-Pearson, Lui
Published in
Journal of diabetes science and technology
Accurate, safe glycemic management requires reliable delivery of insulin doses. Insulin can be delivered subcutaneously for action over a longer period of time. Needle-free jet injectors provide subcutaneous (SC) delivery without requiring needle use, but the volume of insulin absorbed varies due to losses associated with the delivery method. This ...
Lo Presti, Jorge Galderisi, Alfonso Doyle, Francis J 3rd Zisser, Howard C Dassau, Eyal Renard, Eric Toffanin, Chiara Cobelli, Claudio
Published in
Journal of diabetes science and technology
Intraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physi...
Mulindwa, Frank Schwarz, Jean-Marc Brusselaers, Nele Dujanga, Simon Yendewa, George Castelnuovo, Barbara
McHugh, Alexander D Chase, J Geoffrey Knopp, Jennifer L Ormsbee, Jennifer J Kulawiec, Diana G Merry, Troy L Murphy, Rinki Shepherd, Peter R Burden, Hannah J Docherty, Paul D
...
Published in
Journal of diabetes science and technology
Model-based metabolic tests require accurate identification of subject-specific parameters from measured assays. Insulin assays are used to identify insulin kinetics parameters, such as general and first-pass hepatic clearances. This study assesses the impact of intravenous insulin boluses on parameter identification precision. Insulin and C-peptid...
Koh, Han-Chow E. Patterson, Bruce W. Reeds, Dominic N. Mittendorfer, B.
Published in
Obesity (Silver Spring, Md.)
Objective. Studies that used an intravenous glucose tolerance test (IVGTT) suggest race is an important modulator of insulin sensitivity, β-cell function, and insulin clearance. However, the validity of the IVGTT has been challenged. Methods. We assessed insulin sensitivity and insulin kinetics in Non-Hispanic White (NHW, n=29) and African American...
Zisser, Howard
Published in
Journal of diabetes science and technology
This article reviews the concept of using the proper methods for the proper task, in this case measuring dose-to-dose accuracy of continuous subcutaneous insulin infusion pumps.
Leary, Andrew C Dowling, Muiris Cussen, Kathleen O'Brien, Jackie Stote, Robert M
Published in
Journal of diabetes science and technology
This IN formulation was generally well tolerated and relatively well absorbed. While both insulin data (maximal plasma concentration and area under the plasma concentration time curve) and glucose data (% fall) support a trend toward better absorption from the nondominant nostril, this did not reach statistical significance. Nasulin can be administ...
Larsen, M. O. Gotfredsen, C. F. Wilken, M. Carr, R. D. Pørksen, N. Rolin, B.
Published in
Diabetologia
Aims/hypothesisType 2 diabetes is associated with impaired insulin action and secretion, including disturbed pulsatile release. Impaired pulsatility has been related to impaired insulin action, thus providing a possible link between release and action of insulin. Furthermore, progressive loss of beta-cell mass has been implicated in the pathogenesi...
