Hypoxia, a common feature of solid tumours&rsquo / microenvironment, is associated with an aggressive phenotype and is known to cause resistance to anticancer chemo- and radiotherapies. Tumour-associated carbonic anhydrases isoform IX (hCA IX), which is upregulated under hypoxia in many malignancies participating to the microenvironment acidosis, r...
Enega izmed največjih izzivov sodobne medicine predstavljata zdravljenje rakavih obolenj in bakterijskih infekcij. Ljudje smo izpostavljeni številnim kancerogenim dejavnikom, ki lahko privedejo do genskih mutacij in maligne transformacije celic. Zanje je značilna nekontrolirana celična rast oz. nesmrtnost, spremembe v regulaciji celičnega cikla, sp...
Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. Deregulation of the MAPK signaling occurs under many pathological conditions including neurodegenerative ...
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy still remains the main method for cancer treatment. Depending on the mechanism of action, commonly used chemotherapeutic agents can be divided into several classes (antimetabolites, alkylating a...
Published in Current Medical Science
In the 1920s, Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells. Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions. Investigation on energy metabolism pathway in cancer cells has arous...
Over the past two decades, phenol oxidases, particularly laccases and tyrosinases, have been extensively used for the removal of numerous pollutants in wastewaters due to their broad substrate specificity and their ability to use readily accessible molecular oxygen as the essential cofactor. As for other enzymes, immobilisation of laccases and tyro...
Published in Journal of Enzyme Inhibition and Medicinal Chemistry
Farnesyltransferase (FTase) When Ras gene is activated, it becomes an oncogene with oncogenic activity. Ras protein plays a crucial role in cancer cells. FTase is the first step to activate Ras protein. FTIs not only have anti-tumour effects, but also makes great contribution to the treatment of plasmodium falciparum, parasitic diseases and progeri...
Published in Frontiers in Immunology
Neutralizing antibodies to factor VIII (fVIII), referred to as “inhibitors,” remain the most challenging complication post-fVIII replacement therapy. Preclinical development of novel fVIII products involves studies incorporating hemophilia A (HA) and wild-type animal models. Though immunogenicity is a critical aspect of preclinical pharmacology stu...
Published in Beni-Suef University Journal of Basic and Applied Sciences
BackgroundQuinazoline are known to possess different biological activities which among is anti-cancer most especially NSCLC. Epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases (RTKs) family, which is known to be one of the most important therapeutic targets for the treatment of cancer most especially NSCLC.ResultsQSAR ...
Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a more pronounced antitumor effect. Here, we show that baicalein (selective 12-lipoxygenase inhib...
