Sivaraman, Hariharan Er, Shi Yin Choong, Yeu Khai Gavor, Edem Sivaraman, J.
Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other hosts is mediated by host–pathogen interactions, specifically virus–receptor binding. An in-depth...
Nelson, Corey R Mrozowich, Tyler Park, Sean M D'souza, Simmone Henrickson, Amy Vigar, Justin R J Wieden, Hans-Joachim Owens, Raymond J Demeler, Borries Patel, Trushar R
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Published in
International journal of molecular sciences
Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase 17 (DDX17) restricts RVFV replication by recognizing two primary non-coding RNAs in the S-segment of the genome: the intergeni...
Nemani, Satish K Myskiw, Jennifer L Lamoureux, Lise Booth, Stephanie A Sim, Valerie L
Published in
Viruses
The majority of human prion diseases are sporadic, but acquired disease can occur, as seen with variant Creutzfeldt-Jakob disease (vCJD) following consumption of bovine spongiform encephalopathy (BSE). With increasing rates of cervid chronic wasting disease (CWD), there is concern that a new form of human prion disease may arise. Currently, there i...
Spartalis, Eleftherios Kotrotsios, Konstantinos Chrysikos, Dimosthenis Spartalis, Michael Paschou, Stavroula A Schizas, Dimitrios Tsamakis, Konstantinos Dimitroulis, Dimitrios Troupis, Theodore Nikiteas, Nikolaos
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Published in
Current pharmaceutical design
Papillary Thyroid Cancer (PTC) is the most common type of endocrine malignancy. Although PTC has an excellent prognosis, recurrent or metastatic disease could affect patients survival. Recent studies show that Histone Deacetylase Inhibitors (HDACIs) might be promising anticancer agents against PTC. The aim of this review is to evaluate the role of ...
Jukič, Marko Janežič, Dušanka Bren, Urban
Published in
Molecules (Basel, Switzerland)
SARS-CoV-2, or severe acute respiratory syndrome coronavirus 2, represents a new strain of Coronaviridae. In the closing 2019 to early 2020 months, the virus caused a global pandemic of COVID-19 disease. We performed a virtual screening study in order to identify potential inhibitors of the SARS-CoV-2 main viral protease (3CLpro or Mpro). For this ...
Bajc, Enia
Alzheimerjeva bolezen (AB) je najpogostejša oblika demence, ki prizadene predvsem starejšo populacijo ljudi. Zanjo je značilen progresiven kognitivni upad, patološko pa jo lahko okarakteriziramo z zunajcelično agregacijo amiloida beta, znotrajceličnim kopiče-njem nevrofibrilarnih pentelj sestavljenih iz hiperfosforiliranega tau proteina, oksidativ-...
Bilginer, Sinan Gonder, Baris Gul, Halise Inci Kaya, Ruya Gulcin, Ilhami Anil, Baris Supuran, Claudiu T
Published in
Journal of enzyme inhibition and medicinal chemistry
A series of compounds incorporating 3-(3-(2/3/4-substituted phenyl)triaz-1-en-1-yl) benzenesulfonamide moieties were synthesised and their chemical structure was confirmed by physico-chemical methods. Carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the compounds were evaluated against human isoforms hCA I and II. KI values of these sulpho...
Batista, Fernanda A H Ramos, Sérgio L Jr Tassone, Giusy Leitão, Andrei Montanari, Carlos A Botta, Maurizio Mori, Mattia Borges, Júlio C
Published in
Journal of enzyme inhibition and medicinal chemistry
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are molecular chaperones involved in the folding of nascent proteins as well as in the regulation o...
Brichet, Jeremie Arancibia, Rodrigo Berrino, Emanuela Supuran, Claudiu T
Published in
Journal of enzyme inhibition and medicinal chemistry
A series of bio-organometallic-hydrazones of the general formula [{(η5-C5H4)-C(R)=N-N(H)-C6H4-4-SO2NH2}]MLn(MLn = Re(CO)3, Mn(CO)3, FeCp; R=H, CH3) were prepared by reaction of formyl/acetyl organometallic precursors with 4-hydrazino-benzenesulphonamide. All compounds were characterized by conventional spectroscopic techniques (infra-red, 1H and 13...
Dai, Xiaohan Sun, Yingni Zhang, Ting Ming, Yongfei Hongwei, Gao
Published in
Journal of enzyme inhibition and medicinal chemistry
As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours wit...