You, Qiao Wu, Jing Liu, Ye Zhang, Fang Jiang, Na Tian, Xiaoyan Cai, Yurong Yang, Enhui Lyu, Ruining Zheng, Nan
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Published in
Virus research
EV71 (Enterovirus 71) is a major causative agent of the outbreaks of HFMD (hand, foot, and mouth disease), which is associated with neurological damage caused by permeability disruption of BBB (blood-brain barrier). HMGB1 (high-mobility group box 1) is a widely expressed nuclear protein that triggers host inflammatory responses. Our work aimed to e...
Verma, Annu Jakhar, Ritu Kumar, Dev Kumar, Vijay Dhillon, Twinkle Dangi, Mehak Chhillar, Anil Kumar
Published in
Journal of biomolecular structure & dynamics
Medicinal plants possess therapeutic potential for reducing reactive oxygen species (ROS)-mediated cellular damage. Hydroxytyrosol is one of the most potent antioxidants that served as control in the current study, including other synthetic antioxidants to computationally identify the antioxidant properties of Silymarin. The sequences of the recept...
Hao, Huifei Hou, Yuxuan Li, Aicheng Niu, Li Li, Shaolan He, Bingqiang Zhang, Xingyuan Song, Honghua Cai, Rixin Zhou, Yue
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Published in
CNS neuroscience & therapeutics
Macrophage migration inhibitory factor (MIF) is an important mediator of neuropathology in various central nervous system (CNS) diseases. However, little is known about its inducers for production from the nerve cells, as well as the underlying regulatory mechanism. Injury-induced HIF-1α has been shown to exacerbate neuroinflammation by activating ...
Li, Danyi Cao, Wenjie Zhou, Qun Wu, Xiaomin Song, Xiayun Qin, Haofang
Published in
International wound journal
With the outbreak and pandemic of coronavirus disease-2019 (COVID-19), a huge number of people died of it. Apart from lung injuries, multiple organs have been confirmed to be impaired. In COVID-19 time, primary wound healing processes always prolong, however, its possible underlying mechanisms are still unclear. Therefore, to overcome this clinical...
Wang, Yan Li, Guoce Lv, Jianping Zhou, Yingwen Ma, Hongxia
Published in
The International journal of neuroscience
Leukoaraiosis (LA) is a disease manifested by demyelination and gliosis in white matter, mainly caused by cerebrovascular diseases. LA is closely related to the expression level of inflammatory factors, oxidative stress, and vascular endothelial dysfunction in patients. Vitamin E may play antioxidant and anti-inflammatory roles in various diseases....
Xiao, Xue Chen, Sufang Huang, Ziyan Han, Xue Dou, Chaoxun Kang, Jiayi Wang, Tienan Xie, Hanbin Zhang, Linan Hei, Ziqing
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Published in
British journal of pharmacology
Acute lung injury (ALI) is a serious, life-threatening inflammation of the lungs that still lacks effective treatment. We previously showed that serine protease inhibitor B1 (SerpinB1) protects against ALI induced by orthotopic autologous liver transplantation. However, the role of SerpinB1 in lipopolysaccharide (LPS)-induced ALI and its regulatory...
Wu, Lin Huang, Weiyi Liu, Xiaoxiao Yang, Baochun
Published in
Vascular
To investigate the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis. 80 patients with vulnerable carotid atherosclerosis who were admitted to the Department of Cardiology in Wuxi Second People's Hospital between February 2020 and October 2021 were enrolled in this study. All of these patients were randomly divided in...
Loinard, Celine Benadjaoud, Mohamed‐amine L'Homme, Bruno Flamant, Stephane Baijer, Jan Tamarat, Radia
Abstract Local overexposure to ionizing radiation leads to chronic inflammation, vascular damage and cachexia. Here we investigate the kinetics of inflammatory cells from day (D)1 to D180 after mouse hindlimb irradiation and analyze the role of monocyte (Mo) subsets in tissue revascularization. At D1, we find that Mo and T cells are mobilized from ...
Li, Lihua Chen, Jun Zhou, Yun Zhang, Jiahua Chen, Lei
Published in
Archives of physiology and biochemistry
Artesunate (ART), an antimalarial drug, possesses the ability to induce autophagy and exhibits a protective effect on diabetes. This study aimed to evaluate the effects of ART on diabetic retinopathy (DR) and to explore the underlying mechanisms. Rats with streptozotocin-induced DR were given intravitreal injection of ART. ART administration inhibi...
Field, Rowena Field, Tara Pourkazemi, Fereshteh Rooney, Kieron
Published in
Nutrition research reviews
Dietary restriction of carbohydrate has been demonstrated to be beneficial for nervous system dysfunction in animal models and may be beneficial for human chronic pain. The purpose of this review is to assess the impact of a low-carbohydrate/ketogenic diet on the adult nervous system function and inflammatory biomarkers to inform nutritional resear...
