Ferrao Blanco, Mauricio N Bastiaansen Jenniskens, Yvonne M Kops, Nicole Chavli, Athina Narcisi, Roberto Botter, Sander M Leenen, Pieter J M van Osch, Gerjo J V M Fahy, Niamh
Published in
British journal of pharmacology
Corticosteroids such as triamcinolone acetonide (TAA) are potent drugs administered intra-articularly as an anti-inflammatory therapy to relieve pain associated with osteoarthritis (OA). However, the ability of early TAA intervention to mitigate OA progression and modulate immune cell subsets remains unclear. Here, we sought to understand the effec...
English, Carolyn J Mayr, Hannah L Lohning, Anna E Reidlinger, Dianne P
Published in
Nutrition reviews
Atherosclerosis is a disease of chronic inflammation. Recent research has identified 2 novel inflammatory biomarkers: platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA2). Diet has been proposed as a mediator of inflammation, but to date, the focus for these novel biomarkers has been on individual foods and nutrien...
Alamil, Juman Mohammed Rasmi Paudel, Keshav Raj Chan, Yinghan Xenaki, Dikaia Panneerselvam, Jithendra Singh, Sachin Kumar Gulati, Monica Jha, Niraj Kumar Kumar, Deepak Prasher, Parteek
...
Published in
Molecules (Basel, Switzerland)
The inflammatory response is a central aspect of the human immune system that acts as a defense mechanism to protect the body against infections and injuries. A dysregulated inflammatory response is a major health concern, as it can disrupt homeostasis and lead to a plethora of chronic inflammatory conditions. These chronic inflammatory diseases ar...
Xu, Yani Shi, Yaohui Huang, Jingxia Gu, Hongtao Li, Chunlian Zhang, Lanyue Liu, Guanting Zhou, Wei Du, Zhiyun
Published in
Molecules (Basel, Switzerland)
Psoriasis is reported to be a common chronic immune-mediated skin disease characterized by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty acids, and flavonoids, which are recognized for their antioxidant and anti-inflammatory effects. In this study, the alleviating effect of essential oil (PO) extrac...
Krijbolder, Doortje I Wouters, Fenne van Mulligen, Elise van der Helm-van Mil, Annette H M
Published in
Rheumatology (Oxford, England)
Morning stiffness (MS) is characteristic of RA and associates with markers of systemic and local inflammation in RA patients. In patients with arthralgia, MS is a cardinal symptom to recognize arthralgia at-risk for RA development [i.e. clinically suspect arthralgia (CSA)]. In CSA, MS is also assumed to reflect inflammation, but this has never been...
Rempenault, Claire Mielle, Julie Schreiber, Kristina Corbeau, Pierre Macia, Laurence Combe, Bernard Morel, Jacques Daien, Claire Immediato Audo, Rachel
Published in
Rheumatology (Oxford, England)
Chemokines (CKs) are key players of immune-cell homing and differentiation. CK receptors (CKRs) can be used to define T-cell functional subsets. We aimed to characterize the CKR profile of the regulatory B-cell subset B10+ cells and investigate the CKs involved in their migration and differentiation in healthy donors and patients with RA. RNA seque...
Maksymowych, Walter P Østergaard, Mikkel Landewé, Robert Barchuk, William Liu, Ke Tasset, Chantal Gilles, Leen Hendrikx, Thijs Besuyen, Robin Baraliakos, Xenofon
...
Published in
Rheumatology (Oxford, England)
To assess the effect of filgotinib, which preferentially inhibits Janus kinase 1 (JAK1), on MRI measures of structural change in the SI joint in patients with active AS in the TORTUGA trial. Adults with active AS and inadequate response/intolerance to two or more NSAIDs were randomized 1:1 to filgotinib 200 mg (n = 58) or placebo (n = 58) once dail...
Chang, Yu-Sheng Chen, Jin-Hua Lin, Tzu-Min Hsu, Hui-Ching Chen, Wei-Sheng Lin, Sheng-Hong Kuo, Pei-I Lin, Yi-Chun Chang, Chi-Ching
Published in
Rheumatology (Oxford, England)
RA damages the joints and increases the risks of total knee replacement (TKR) and total hip replacement (THR). However, the benefits of biologics in preventing TKR or THR remain unclear. This retrospective nationwide study used the 2000-2013 claims-based National Health Insurance dataset. Biologics are reimbursed for refractory cases. The risks of ...
Subesinghe, Manil Bhuva, Shaheel Arumalla, Nikita Cope, Andrew D'Cruz, David Subesinghe, Sujith
Published in
Rheumatology (Oxford, England)
2-deoxy-2[18F]fluoro-D-glucose (FDG) PET-CT has revolutionized oncological imaging. The cellular processes that make cancer cells visible on FDG PET-CT also occur in a number of inflammatory cells. Exploiting this phenomenon has led to a growth of evidence supporting the use of FDG PET-CT in a wide range of infective and inflammatory diseases. Rheu...
Neculachi, Carmen Alexandra Leti, Livia Ioana Burlacu, Alexandrina Preda, Mihai Bogdan
Published in
Romanian Journal of Cardiology
Mesenchymal stromal cells (MSC) are nonhematopoietic cells with fibroblast-like morphology and multipotent capacity that are widely used in pre-clinical and clinical investigations. Unfortunately, the efficiency of MSC treatment is hindered by the poor survival rate after transplantation at the damaged tissue. The goal of this study was to investig...
